Toxicology of male reproduction in animals and humans

Archives of Andrology

Volumn 37, Issue 3, 1996, Pages 201-218

  De Celis, R ^a,c   Pedron Nuevo N ^a   Feria Velasco, A ^b  

^a Institut0 Mexicano del Seguro Social   (Mexico)

^b HOSPITAL DE ESPECIALIDADES   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Environmental agents; Male infertility; Male reproduction; Metals; Occupational exposure to toxic agents; Organic compounds; Physical agents; Toxic action; Toxicity

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; CARBON DISULFIDE; CHLORDECONE; CHLORPHENAMIDINE; COPPER; DIBROMOCHLOROPROPANE; DRUG; ESTROGEN; GOSSYPOL; HALOGENATED HYDROCARBON; HEAVY METAL; LEAD; MANGANESE; ORGANIC COMPOUND; PESTICIDE; POLYCHLORINATED BIPHENYL;

ANIMAL; ENVIRONMENTAL FACTOR; HUMAN; INFERTILITY; MALE; NONHUMAN; OCCUPATIONAL MEDICINE; PRIORITY JOURNAL; REVIEW;

EID: 79961229450     PISSN: 01485016     EISSN: None     Source Type: Journal    
DOI: 10.3109/01485019608988523     Document Type: Review

References (156)

1. Albert L, Cebrian ME, Mendez F, et al (1980): Organochlorine pesticide residues in human adipose tissue in Mexico: results of a preliminary study in three Mexican cities. Arch Environ Health 35:262-269.
2. Albert L, Vega P, Portales A (1981): Organochlorine pesticides residues in human milk samples from Comarca Lagunera, Mexico, 1976. Pestic Monit J 15:135-138.
3. Allen JR (1975): Responses of the nonhuman primate to polychlorinated biphenyl exposure: research activities at regional primate centers. Fed Proc 34:1675-1679.
4. Amann RP (1970): Sperm production rates. In: The Testis, Vol 1, Scialli AR, Zinaman MJ, eds. NewYork: Academic, pp 433-482.
5. Amann RP, Howards SS (1980): Daily spermatozoal production and epididymal spermatozoal reserves of the human male. J Urol 124:211-215.
6. Amelar RD, Dubin L, Hotchkiss RS (1971): Restoration of fertility following unilateral orchiectomy and radiation therapy for testicular tumors. J Urol 106:714-718.
7. Archivos del Departamento de Epidemiologia (1984). Laboratorio Nacional de Referenda de la Secretaría de Salubridad y Asistencia. Mexico, pp 45-87.
8. Ash P (1980): The influence of radiation on fertility in man . Br J Radiol 53:271-278.
9. Assennato G, Paci C, Baser ME, et al (1987): Sperm count suppression without endocrine dysfunction in lead-exposed men. Arch Environ Health 42:124-127.
10. Baker HW, Bremner WJ, Burger HG, et al (1976): Testicular control of FSH secretion. Recent Prog Horm Res 32:429-476.
11. Baker HW (1990): Testicular dysfunction in systemic disease. In: Principles and Practice of Endocrinology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, pp 971-975.
12. Bedford JM (1991): Effects of elevated temperature on the epididymis and testis: experimental studies. Adv Exp Med Biol 286:19-32.
13. Benson GS (1994): Male sexual function: erection, emission, and ejaculation. In: The Physiology of Reproduction, Knobil E, Neill JD, eds. New York: Raven, pp 1489-1508.
14. Bitman J, Cecil HC (1970): Estrogenic activity of DDT analogs and polychlorinated biphenyls. J Agric Food Chem 18:1108-1112.
15. Blackman MR (1990): Aging and endocrinology. In: Principles and Practice of Endocrinology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, pp 1461-1469.
16. Bonde JPE (1993): The risk of male subfecundity attributable to welding of metals: studies of semen quality, infertility, fertility, adverse pregnancy outcome and childhood malignancy. Int J Androl 16(Suppl 1):1-29.
17. Braun CLJ, Kolk JJ (1985): Zwavelkoolstof en het reproductievermogen van de man. T Soc Gezondheidsz 63:379-383.
18. Braunstein GD, Dahlgren J, Loriaus DL (1978): Hypogonadism in chronically lead-poisoned men. Infertility 1:33-51.
19. Bremmer WJ (1990): Pituitary gonadotropins and their disorders. In: Principles and Practice of Endocnnology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, p 152.
20. Cannon SB, Veazey JM Jr, Jackson RS, et al (1978): Epidemic kepone poisoning in chemical workers. Am J Epidemiol 107:529-537.
21. Carlsen E, Giwerckman A, Keiding N, et al (1992): Evidence for decreasing quality of semen during the past 50 years. Br Med J 305:609-613.
22. Cavalleri A (1975): Serum thyroxine in the early diagnosis of carbon disulfide poisoning. Arch Environ Health 30:85-87.
23. Cavalleri A, Djuric D, Maugeri U, et al (1967): 17-ketosteroids and 17-hydrocorticosteroids in the urine of young workers exposed to carbon disulfide. In: Toxicology of carbon disulphide, Brieger H, Teisinger J, eds. Amsterdam: Excerpta Medica, pp 86-91.
24. Cavalleri A, Maugeri U, Visconti E (1970): Urinary excretion of testosterone and gonadotropins stimulating interstitial cells (ICSH) in person exposed to carbon disulfide. Arch Mal Prof 31:23-30.
25. Chia SE, Ong CN, Tsakok FMH (1994): Effects of cigarette smoking on human semen quality. Arch Androl 33:163-168.
26. Cirla AM, Bertazzi PA, Tomasini M, et al (1978): Study of endocrinological functions and sexual behaviour in carbon disulphide workers. Med Lav 69:118-129.
27. Cirla AM, Graziano C (1981): Health impairment in viscose-rayon workers with carbon disulfide risk below 30 mg/m3: an exposed-controls study. G Ital Med Lav 3:69-73.
28. Cohn WJ, Boylan JJ, Blanke RV, et al (1978): Treatment of chlordecone (Kepone) toxicity with cholestyramine: results of a controlled clinical trial. N Engl J Med 298:243-248.
29. Comhaire FS (1987): Simple model and empirical method for the estimation of spontaneous pregnancies in couples consulting for infertility. Int J Androl 10:671-680.
30. Coutinho EM, Segal SJ, Melo JF, et al (1985): Biphasic action of gossypol in men. In: Gossypol: A Potential Contraceptive for Men, Segal SJ, ed. New York: Plenum, pp 25-32.
31. Cullen MR, Kayne RD, Robins JM (1984): Endocrine and reproductive dysfunction in men associated with occupational inorganic lead intoxication. Arch Environ Health 39:431-440.
32. Cummins JM, Pember SM, Jequier AM, et al (1991): A test of human sperm acrosome reaction following ionophore challenge: relationship to fertility and other seminal parameters. J Androl 12:98-103.
33. Damstra T, Kurokawa Y (1993): The fourth United States-Japan meeting on toxicological characterization of environmental chemicals. Environ Health Perspect 101:644-649.
34. Daniels CR, Paul ME, Rosofsky R (1990): Health, equity, and reproductive risks in the workplace. J Public Health Policy 11:449-462.
35. De Celis R, Pedrón N, Carranza-Lira S, et al (1996): Micronúcleos: una probable herramienta diagnóstica para la valoración de la respuesta a la Terapia Estrogénica de reemplazo. Proc Jornada Med Bienal. Hosp GO No 4, IMSS. 6:71-72.
36. Derr SK, Dekker J (1979): Alterations of androgenicity in rats exposed to PCBs (Aroclor. 1254) Bull Environ Contam Toxicol 21:43-45.
37. Egeland GM, Sweeney MH, Fingerhut MA, et al (1994): Total serum testosterone and gonadotropins in workers exposed to dioxin. Am J Epidemiol 139:272-281.
38. Eggert-Kruse W, Rohr G, Jochum R, et al (1990): Influence of heavy metals on sperm-mucus interaction in vitro. II Joint Meeting ESURE-ESCO, Milan. Hum Reprod 5(Suppl 1), Abstr No 158.
39. Egnatz DG, Ott MG, Townsend JC, et al (1980): DBCP and testicular effects in chemical workers: an epidemiological survey in Midland, Michigan. J Occup Med 22:727-732.
40. El-Sobkey MK, Massoud AAE, Abdel-Karim, et al (1979): Serum thyroxine serum cholesterol and its fractions in workers exposed to carbon disulphide. J Egypt Publ Health Assoc 54:431-442.
41. Evans WS, Carlsen E, Ho KY (1990): Prolactin and its disorders. In: Principles and Practice of Endocrinology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, p 134.
42. Feichtinger W (1991): Environmental factors and fertility. Hum Reprod 6:1170-1175.
43. Figa-Talamanca I, Hatch MC (1994): Reproduction and the workplace: what we know end where we go from here. Int J Occup Med Tox 3:279-303.
44. Fink G (1988): Gonadotropin secretion and its control. In: The Physiology of Reproduction, Knobil E, Neill JD, eds. New York: Raven, pp 1349-1377.
45. Foster PMD, Creasy DM, Foster JR, et al (1984): Gray TJB. Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat. Environ Health Perspect 57:207-217.
46. Fredricsson B, Moller L, Pousette A, et al (1993): Human sperm motility is affected by plasticizers and diesel particle extracts. Pharmacol Toxicol 72:128-133.
47. Frick J, Danner C (1985): Effect of gossypol on human teslicular function: evaluation of seminal and hormonal parameters. In: Gossypol: A Potential Contraceptive for Men, Segal SJ, ed. New York: Plenum, pp 17-24.
48. Gennart JP, Buchet JP, Roel H, et al (1992): Fertility of male workers exposed to cadmiun, lead or manganese. Am J Epidemiol 135:1208-1219.
49. Godfrey B (1981): Sperm morphology in smokers. Lancet 1:948.
50. Goldman JM, Cooper RL, Laws SC, et al (1990): Chlordimeform-induced alterations in endocrine regulation within the male rat reproductive system. Toxicol Appl Pharmacol 104:25- 35.
51. Grampella D (1982): Research on workers exposed to CS2 at SNIA's plant in Pavia. Paris: CIRFS, pp 66-72.
52. Guzelian PS (1982): Comparative toxicology of chlordecone (kepone) in humans and experimental animals. Annu Rev Pharmacol Toxicol 22:89-113.
53. Harrington JM (1982): Occupational exposure to synthetic estrogens: some methodological problems. Scand J Work Environ Health 8(Suppl 1):167-171.
54. Hassman P, Simko A, Jindrichova J, et al (1967): The problem of chronic gastritis in workers in the artificial fibre industry. In: Toxicology of Carbon Disulphide, Brieger H, Teisinger J, eds. Amsterdam: Excerpta Medica, pp 182-189.
55. Hembree WC III, Nahas GG, Zeidenbert P, et al (1979): Changes in human spermatozoa associated with high dose marijuana smoking. Adv Biose 22:23.
56. Hoffer AP (1985): Ultrastructural, biochemical and endocrine studies on the effects of gossypol and its isomeric derivatives on the male reproductive tract. In: Gossypol. A Potential Contraceptive for Men, Segal SJ, ed. New York: Plenum, pp 143-186.
57. Holland MK, White IG (1988). Heavy metals and human spermatozoa, III. the toxicity of copper ions for spermatozoa. Contraception 38:685-695.
58. Indulski J, Kowalski Z (1990): The strategy of targetted health surveillance, I: evaluation of health effects of exposure to carcinogens, malformations and neoplasms in children. Reproduction disorders. Pol J Occup Med 3:273-284.
59. International Agency for Research on Cancer (1988): Tobacco smoking. IARC monographs on the evaluation of the carcinogenic risk of chemical to humans, Vol. 38. International Agency for Research on Cancer, Lyon.
60. James WH (1980): Secular trend in reported sperm counts. Andrologia 12:381-388.
61. Klinefelter G, Gray LE Jr. (1993): The clinical relevance of animal models, animal studies that assess the potential for chugs and environmental agents to cause reproductive disorders in humans. In: Reproductive Toxicology and Infertility, cialli AR, Zinaman MJ, eds. New York. McGraw Hill, pp 219-282.
62. Kolmodin-Hedman B (1989): Adverse working environment decreases fertility. Lakartidningen 86:4604-4609.
63. Kordon C, Drouva SV (1990): Interplay between hypothalamic hormones and sex steroids in the control of neuroendocrine reproductive functions. In: Neuroendocrine Regulation of Reproduction, Yen SSC, Vale WW, eds. Norwell, MA: Serono Symposia, pp 259-268.
64. Krasovskii GN, Varshavskaya SP, Borisov Al (1976): Toxic and gonadotropin effects of cadmium and boron relative to standards for these substances in drinking water. Environ Health Perspect 13:69-75.
65. Kreuser ED, Klingmuller D, Thiel E (1993): The role of LHRH-analogues in protecting gonadal functions during chemotherapy and irradiation. Eur Urol 23:157-164.
66. Kvist U, Bjornadahl L, Steen U, et al (1988): Quality of sperm: a question on number, shape or content? Nord Med 103:312-315.
67. Lamb EJ, Bennett S (1994): Epidemiologic studies of male factors in infertility. In: Human Reproductive Ecology Interactions of Environment, Fertility and Behavior, Campbell KL, Wood JW, eds. Ann NY Acad Sci 709:165-178.
68. Lancranjan I (1972): Alterations of spermatic liquid in patient chronically poisoned by carbon disulphide. Med Lav 63:29-33.
69. Lancranjan I, Popescu HI (1977): Endocrine alterations in carbon disulphide poisoning. Egypt J Occup Med 5:125-129.
70. Lancranjan I, Popescu Hi, Gavanescu O, et al (1975): Reproductive ability of workmen occupationally exposed to lead. Arch Environ Health 30:396-401.
71. Lantz GD, Cunningham GR, Huckins C, et al (1981): Recovery from severe oligospermia after exposure to dibromochloropropane. Fertil Steril 35:46-53.
72. Lauwerys R (1990): Toxicologie Industrielle et Intoxications Profesionnelles 3d ed. Paris: Masson, pp 124-220.
73. Lauwerys R, Roels H, Genet P, et al (1985): Fertility of male workers exposed to mercury vapor or to manganese dust: a questionnaire study. Am J Ind Med 7:171-176.
74. Levine RJ (1983): Methods for detecting occupational causes of male infertility: reproductive history versus semen analysis. Scand J Work Environ Health 9:371-376.
75. Levine RJ, Symons MJ, Balogh SA, et al (1981): A method for monitoring the fertility of workers, 2: validation of the method among workers exposed to dibromochloropropane. J Occup Med 23:183-188.
76. Lipscomb JA, Goldman LN, Satin KP, et al (1991): A follow-up study of the community near the McColl waste disposal site. Environ Health Perspect 94:15-24.
77. Lipshultz LI, Ross CE, Whorton MD, et al (1980): Dibromochloropropane and its effect on testicular function in man. J Urol 124:464-468.
78. Liu GZ, Lyle KC, Cao J (1987): Clinical trial of gossypol as a male contraceptive drug, Part 1: efficacy study. Fertil Steril 48:459-461.
79. Locati G, Cirla AM, Villa A (1970): Prevalence of coronary heart disease among 253 viscose rayon workers admitted to the Clinica del Lavoro of Milan from 1947 to 1969. Med Lav 61:442-446.
80. Lu CC, Meistrich ML (1979): Cytotoxic effects of chemotherapeutic drugs on mouse testis cells. Cancer Res 39:3575-3582.
81. Mably TA, Bjerke DL, Moore RW, et al (1992): In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3: effects on spermatogenesis and reproductive capability. Toxicol Appl Pharmacol 114:118-126.
82. MacLeod J, Hotchkiss RS, Sitterson BW (1964): Recovery of male fertility after sterilization by nuclear radiation. J Am Med Assoc 187:637-641.
83. Magos L (1987): Biological methods of defining human exposures. In: Health Effects from Hazardous Waste Sites, Andelman JB, Dwight WU, eds. Chelsea, MI: Lewis, pp 121-139.
84. Matanoski G, Fishbein L, Redmond C, et al (1986): Contribution of organic particulates to respiratory cancer. Environ Health Perspect 70:37-49.
85. Mattison DR, Plowchalk DR, Meadows MJ, et al (1990): Reproductive toxicity: male and female reproductive systems as targets for chemical injury. Med Clin North Am 74:391-411.
86. Maugeri S, Cavalleri A, Maugeri U, et al (1971): New aspects in the pathogenetic mechanism of carbon disulphide toxic action. Med Lav 62:398-403.
87. McMaster SB (1993): Developmental toxicity, reproductive toxicity, and neurotoxicity as regulatory endpoints. Toxicol Lett 68:225-230.
88. Meistrich ML, Brown CC (1983): Estimation of the increased risk of human infertility from alterations in semen characteristics. Fertil Steril 40:220-230.
89. Meistrich ML, Hunter NR, Suzuki N, et al (1978): Gradual regeneration of mouse testicular stem cells after exposure to ionizing radiation. Radiat Res 74:349-362.
90. Mendelson JH (1987): Marijuana. In: Psychopharmacology: The Third Generation of Progress, Meltzer HY, ed. NewYork: Raven, pp 1565-1570.
91. Menkveld R, Van Zyl JA, Kotze TJ, et al (1986): Possible changes in male fertility over a 15-year period. Arch Androl 17:143-144.
92. Merlevede E (1951): Bijdrage tot de Toxicologie van Zwavelkoolstof. Brugge: Sint-Catharina, p 107.
93. Meyer CR (1981): Semen quality in workers exposed to carbon disulfide compared to a control group from the same plant. J Occup Med 23:435-439.
94. Milby TH, Whorton MD (1980): Epidemiological assessment of occupationally related, chemically induced sperm count suppression. J Occup Med 22:77-82.
95. Mortensen JT (1988): Risk for reduced sperm quality among metal workers, with special reference to welders. Scand J Work Environ Health 14:27-30.
96. Moses M, Lilis R, Crow KD, et al (1984): Health status of workers with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the manufacture of 2,4,5-trichloro-phenoxyacetic acid: comparison of findings with and without chloracne. Am J Ind Med 5:161-182.
97. National Coordinating Group on Male Antifertility Agents (1978): Gossypol - A new antifertility agent for males. Chin Med J Engl 4:417-428.
98. National Research Council (1983): Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Academy Press.
99. National Institutes for Occupational Safety and Health (1977): Occupational exposure to carbon disulfide: criteria for a recommended standard. Washington, DC: US Government Printing Office.
100. Noth RH, Walter RM (1990): Metabolic effects of alcohol. In: Principles and Practice of Endocrinology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, pp 1679- 1684.
101. Olsen GW, Lanham JM, Bodner KM, et al (1990): Determinants of spermatogenesis recovery among workers exposed to 1,2-dibromo-3-chloropropane. J Occup Med 32:979-984.
102. Osser S, Beckman-Ramirez A, Liedholm P (1992): Semen quality of smoking and non-smoking men in infertile couples in a Swedish population. Acta Obstet Gynecol Scan 71:215-218.
103. Paul M, Daniels C, Rosofsky R (1989): Corporate response to reproductive hazards in the workplace: results of the familily, work and health survey. Am J Ind Med 16:267-280.
104. Pease W, Vandenberg J, Hooper K (1991): Comparing alternative approaches to establishing regulatory levels for reproductive toxicants: DBCP as a case study. Environ Health Perspect 91:141-155.
105. Potashnik G, Yanai-Inbar I (1987): Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance. Fertil Steril 47:317-323.
106. Qian SZ, Wang ZG (1984): Gossypol: a potential antifertility agent for males. Annu Rev Pharmacol Toxicol 24:329-360.
107. Randel RD, Chase CC Jr, Wyse SJ (1992): Effects of gossypol and cottonseed products on reproduction of mammals. J Anim Sci 70:1628-1638.
108. Rao KS, Burek JD, John JA, et al (1983): Toxicologic and reproductive effects of inhaled 1,2-dibromo-3-chloropropane in rats. Fundam Appl Toxicol 3:104-110.
109. Rao KS, Burek JD, Murray FJ, et al (1982). Toxicologic and reproductive effects of inhaled 1,2-dibromo-3-chloropropane in male rabbits. Fundam Appl Toxicol 2:241-251.
110. Ratcliffe JM, Schrader SM, Clapp DE, et al (1989): Semen quality in workers exposed to 2-ethoxyethanol. Br J Ind Med 46:399-406.
111. Ratcliffe JM, Schrader SM, Steenland K, et al (1987): Semen quality in papaya workers with long-term exposure to ethylene dibromide. Br J Ind Med 44:317-326.
112. Rodriguez MC, Sanchez-Yague J, Paniagua R (1992): Effects of cocaine on testicular structure in the rat . Reprod Toxicol 6:51-55.
113. Roegner RH, Grubbs WD, Lustik MB, et al (1991): The Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Serum Dioxin Analysis of 1987 Examination Results. Brooks Air Force Base, TX: US Air Force School of Aerospace Medicine (NTIS No ADA-237521).
114. Rowley MJ, Leach DR, Warner GA, et al (1974): Effects of graded doses of ionizing radiation on human testes. Radiat Res 59:655-678.
115. Rubin HH, Arieff AJ (1945): Carbon disulfide and hydrogen sulfide: a clinical study of chronic low-grade exposures. J Ind Hyg Toxicol 27:123-129.
116. Scala RA, Bevan C, Beyer BK (1992): An abbreviated repeat dose and reproductive developmental toxicity test for high production volume chemical. Regul Toxicol Pharmacol 16:73-80.
117. Schilsky RL, Lewis BJ, Sherins RJ, et al (1980): Gonadal dysfunction in patients receiving chemotherapy for cancer. Ann Intern Med 93:109-114.
118. Schirren C (1961): Fertilitätsstörungen des mannes. In: Beiträge zu Sexualforschung, Bürger Prinz VH, Giese H, eds. Heft ZZ. Stuttgart: Enke, p 67.
119. Schrader SM (1992): Data gaps and new methodologies in the assessment of male fecundity in occupational field studies. Scand J Work Environ Health 18(Suppl 1) 2:30-32.
120. Schrader SM, Turner TW, Ratcliffe JM (1988): The effects of ethylene dibromide on semen quality: a comparison of short-term and chronic exposure. Reprod Toxicol 2:191-198.
121. Sharpe RM, Skakkebaek EN (1993): Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392-1395.
122. Silbergeld EK (1983): Effects of lead on reproduction: review of experimental studies. In: Lead Versus Health, Rutter M, Jones RR, eds. New York: Wiley, pp 217-226.
123. Silva OL (1990): Metabolic effects of tobacco and cannabis. In: Principles and Practice of Endocrinology and Metabolism, Becker KL, ed. Philadelphia, PA: JB Lippincott, pp 1684-1686.
124. Skakkebaek NE, Giwercman A, de Kretser D (1994): Pathogenesis and management of male infertility. Lancet 343:1473-1479.
125. Smith JP, Smith JC, McCall AJ (1960): Chronic poisoning from cadmium fumes. J Pathol Bacteriol 80:287-293.
126. Stachel B, Dougherty RC, Lahl U, et al (1989): Toxic environmental chemical in human semen: analytical method and case studies. Andrologia 21:282-291.
127. Steinberger E, Lloyd JA (1985): Chemical affecting the development of reproductive capacity. In: Reproductive Toxicology, Dixon RL, ed. New York: Raven, pp 15-27.
128. Taylor JR, Selhorst JB, Houff SA, et al (1978): Chlordecone intoxication in man, I: clinical observations. Neurology 28:626-630.
129. Ter Haar G (1981): Response by Ethyl Corp to EPA Concerning the RPAR on Ethylene Dibromide (OPP 3000/25B). Baton Rouge, LA.
130. Tuohimaa P, Wichmann L (1985): Sperm production of men working under heavy-metal or organic-solvent exposure. In: Occupational Hazards and Reproduction, Hemminki K, Sorsa M, Vainio H, eds. Washington, DC: Hemisphere, pp 73-79.
131. US Environmental Protection Agency (1988): Proposed guidelines for the assessment of male reproductive risk. In Federal Register 24850-24869, p 53.
132. Vanhoorne M, Comhaire F, De Bacquer D (1994): Epidemiological study of the effects of carbon disulfide on male sexuality and reproduction. Arch Environ Health 49:273-278.
133. Vanhoorne M, Vermeulen A, De Bacquer D (1993): Epidemioiogical study of endocrinological effects of carbon disulfide. Arch Environ Health 48:370-375.
134. Vermeulen A, Rubens R, Verdon L (1972): Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 34 730-735.
135. Veulemans H, Steeno O, Masschelein R, et al (1993): Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case control study. Br J Ind Med 50:71-78.
136. Vigliani EC (1954): Carbon disulphide poisoning in viscose rayon factories. Br J Ind Med 11:235-244.
137. Wägar G, Tolonen M, Tanner P, et al (1983): Serum gonadotropins and testosterone in men occupationally exposed to carbon disulfide. J Toxicol Environ Health 11:691-701.
138. Wagner U, Schlebusch H, Van der Ven H, et al (1990): Accumulation of pollutants in the genital tract of sterility patients. J Clin Chem Clin Biochem 28:683-688.
139. Waliszewski M, Szymczynski GA (1990): Determination of phthalate esters in human semen. Andrologia 22:69-73.
140. Wassermann M, Wassermann D, Cucos S, et al (1979): World PCBs map: storage and effects in man and his biologic environment in the 1970s. Ann NY Acad Sci 320:69-124.
141. Welch LS, Schrader SM, Turner TW, et al (1988): Effect of exposure to ethylene glycol ethers on shipyard painters, II: male reproduction. Am J Ind Med 14:509-526.
142. Whorton MD, Foliart DE (1983): Mutagenicity, carcinogenicity and reproductive effects of dibromochloropropane (DBCP). Mutat Res 123:13-30.
143. Whorton MD, Krauss RM, Marshall S, et al (1977): Infertility in male pesticide workers. Lancet 2:1259-1261.
144. Whorton MD, Meyer CR (1981): Sperm count results from 861 American chemical/agricultural workers from 14 separate studies. Fertil Steril 35:46-53.
145. Whorton MD, Milby TH, Stubbs HA, et al (1979): Testicular functions among carbaryl-exposed employees. J Toxicol Environ Health 5:929-941.
146. Wildt K, Eliasson R, Berlin M (1983): Effects of occupational exposure to lead on sperm and semen. In: Reproductive and Developmental Toxicity of Metals, Clarkson TW, Nordberg GF, Sager PR, eds. New York: Plenum, pp 279-300.
147. Winder C (1993): Lead, reproduction and development. Neurotoxicology 14:303-317.
148. Wink A (1972): Effect of long-term exposure to low levels of toxic substances on urinary excretion of 17-oxogenic steroids and 17-oxosteroids. Ann Occup Hyg 15:211-217.
149. Wolfe WH, Michalek JE, Miner JC, et al (1992): The Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Reproductive Outcomes. Brooks Air Force Base TX: US Air Force School of Aerospace Medicine (NTIS No ADA-255262).
150. World Health Organization (1990): 2-Methoxyethanol, 2-ethoxyethanol, and their acetates. Environ Health Crit 1990, p115.
151. World Health Organization (1992): Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. Cambridge, UK: Cambridge University Press, p 80.
152. World Health Organization (1979): Carbon Disulfide. Geneva: World Health Organization.
153. Wyrobek AJ, Gordon LA, Burkhart JG, et al (1983): An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function: a report of the US Environmental Protection Agency Gene-Tox Program. Mut Res 115:73-148.
154. Zaneveld LJD, Waller DP (1989): Nonhormonal mediation of male reproductive tract damage: data from contraceptive drug research. Prog Clin Biol Res 302:129-156.
155. Zapata-Gayon N, Zapata-Gayon C, González-Angulo A (1987): Blastogenic changes in the chromosomes of a population of individuals occupationally exposed to different pesticides. Salud Publica Mex 29:506-511.
156. Zmirou D, Deloraine A, Saviuc P, et al (1994): Short-term health effects of an industrial toxic waste landfill: a retrospective follow-up study in Montchanin, France. Arch Environ Health 49:228-238.