The liquid Panax ginseng inhibits epidermal growth factor-induced metalloproteinase 9 and cyclooxygenase 2 expressions via inhibition of inhibitor factor kappa-B-alpha and extracellular signal-regulated kinase in NCI-H292 human airway epithelial cells

American Journal of Rhinology and Allergy

Volumn 25, Issue 2, 2011, Pages

  Kim, Jung Hee ^a   Kang, Jeong Woo ^a   Kim, ManSub ^a   Lee, Dong Hun ^a   Kim, Heejong ^a   Choi, Hee Sook ^a   Kim, Eun Jin ^a   Chung, Ill Min ^a   Chung, Il Yup ^b   Yoon, Do Young ^a  

^a Konkuk University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; GELATINASE B; I KAPPA B ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 5AC;

ARTICLE; CANCER CELL CULTURE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GINSENG; HUMAN; HUMAN CELL; INHIBITION KINETICS; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYMOGRAPHY;

CELL LINE, TUMOR; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION; HUMANS; HYPERSENSITIVITY; I-KAPPA B KINASE; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUCIN 5AC; PANAX; PLANT EXTRACTS; PLANT ROOTS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 79953249841     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2011.25.3586     Document Type: Article

References (36)

1. Kim KR, Chung TY, Shin H, et al. Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Biol Pharm Bull 33:604-610.
2. Choo MK, Sakurai H, Kim DH, and Saiki I. A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep 19:595-600, 2008. (Pubitemid 351330423)
3. Bae EA, Han MJ, Shin YW, and Kim DH. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull 29:1862-1867, 2006.
4. Ni W, Zhang X, Wang B, et al. Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracil. J Med Food 13:270-277.
5. Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 29:1109-1118, 2008.
6. Choi RC, Zhu JT, Leung KW, et al. A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: Signaling transduction and drug development for Alzheimer's disease. J Alzheimers Dis 19:795-811.
7. Geng J, Peng W, Huang Y, Fan H, Li S. Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. Eur J Pharmacol 634:162-169.
8. Su W, Sun AJ, Xu DL, et al. Inhibiting effects of total saponins of panax ginseng on immune maturation of dendritic cells induced by oxidized-low density lipoprotein. Cell Immunol 263:99-104.
9. Purev M, Kim YJ, Kim MK, et al. Isolation of a novel catalase (Cat1) gene from Panax ginseng and analysis of the response of this gene to various stresses. Plant Physiol Biochem 48:451-460.
10. Lee ST, Chu K, Sim JY, et al. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 22: 222-226, 2008.
11. Yuan HD, and Chung SH. Protective effects of fermented ginseng on streptozotocin-induced pancreatic beta-cell damage through inhibition of NF-kappaB. Int J Mol Med 25:53-58.
12. Zhu JR, Tao YF, Lou S, and Wu ZM. Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells. Acta Pharmacol Sin 31:273-280.
13. Peng XD, Dai LL, Huang CQ, et al. Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem Biophys Res Commun 388:31-34, 2009.
14. Babayigit A, Olmez D, Karaman O, et al. Ginseng ameliorates chronic histopathologic changes in a murine model of asthma. Allergy Asthma Proc 29:493-498, 2008.
15. Kim JH, Chang JH, Yoon JH, et al. [6]-Gingerol suppresses interleukin- 1 beta-induced MUC5AC gene expression in human airway epithelial cells. Am J Rhinol Allergy 23:385-391, 2009.
16. Chang JH, Song KJ, Kim HJ, et al. Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa. Am J Rhinol Allergy 24:e59-e62.
17. Kim YD, Kwon EJ, Park DW, et al. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol 62:1112-1118, 2002.
18. Chen JJ, Huang WC, and Chen CC. Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein delta and CREB-binding protein. Mol Biology Cell 16:5579-5591, 2005.
19. Chen CC, Sun YT, Chen JJ, and Chiu KT. TNF-alpha-induced cyclooxygenase- 2 expression in human lung epithelial cells: Involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. J Immunol 165:2719-2728, 2000.
20. Gray T, Nettesheim P, Loftin C, et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase- 2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol 66:337-346, 2004. (Pubitemid 38989491)
21. Kim JH, Lee SY, Bak SM, et al. Effects of matrix metalloproteinase inhibitor on LPS-induced goblet cell metaplasia. Am J Physiol 287: L127-L133, 2004. (Pubitemid 38787659)
22. Wang Y, Shen Y, Li K, et al. Role of matrix metalloproteinase-9 in lipopolysaccharide-induced mucin production in human airway epithelial cells. Arch Biochem Biophys 486:111-118, 2009.
23. Binker MG, Binker-Cosen AA, Richards D, et al. LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells. Biochem Biophys Res Commun 386:124-129, 2009.
24. Harrington LS, Lucas R, McMaster SK, et al. COX-1, and not COX-2 activity, regulates airway function: Relevance to aspirin-sensitive asthma. FASEB J 22:4005-4010, 2008.
25. Shao MX, Ueki IF, and Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci USA 100:11618-11623, 2003. (Pubitemid 37205985)
26. Deshmukh HS, Case LM, Wesselkamper SC, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med 171:305-314, 2005. (Pubitemid 40223396)
27. Burgel PR, and Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 59:992-996, 2004. (Pubitemid 39490787)
28. Nash SP, and Heuertz RM. Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine model. Int Immunopharmacol 5:1870-1880, 2005.
29. Choi HS, Cho MC, Lee HG, and Yoon DY. Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells. Food Chem Toxicol 48:883-890.
30. Leber TM, and Balkwill FR. Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels. Anal Biochem 249:24-28, 1997. (Pubitemid 27251938)
31. Gon Y, Asai Y, Hashimoto S, et al. A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am J Respir Cell Mol Biol 31:330-336, 2004. (Pubitemid 39180303)
32. Roger T, Bresser P, Snoek M, et al. Exaggerated IL-8 and IL-6 responses to TNF-alpha by parainfluenza virus type 4-infected NCIH292 cells. Am J Physiol 287:L1048-L1055, 2004. (Pubitemid 39391036)
33. Saito K, Iwashita J, Murata J, and Abe T. The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells. Anticancer Res 26:1085-1090, 2006.
34. Chen CC, Sun YT, Chen JJ, and Chang YJ. Tumor necrosis factoralpha- induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. Mol Pharmacol 59:493-500, 2001.
35. Mata M, Sarria B, Buenestado A, et al. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 60:144-152, 2005. (Pubitemid 40222898)
36. Itatsu K, Sasaki M, Yamaguchi J, et al. Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. Am J Pathol 174:829-841, 2009.