메뉴 건너뛰기




Volumn 23, Issue 4, 2009, Pages 385-391

[6]-Gingerol suppresses interleukin-1β-induced MUC5AC gene expression in human airway epithelial cells

Author keywords

6 gingerol; Antihypersecretory agent; Extracellular signal regulated kinase; Human airway epithelial cell; Interleukin 1 beta; MUC5AC; p38 mitogen activated protein kinase

Indexed keywords

(6) GINGEROL; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 5AC;

EID: 70349249938     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2009.23.3337     Document Type: Article
Times cited : (16)

References (19)
  • 1
    • 3242755759 scopus 로고    scopus 로고
    • Fresh organically grown ginger ( Zingiber officinale): Composition and effects on LPS-induced PGE2 production
    • Jolad SD, Lantz RC, Solyom AM, et al. Fresh organically grown ginger ( Zingiber officinale): Composition and effects on LPS-induced PGE2 production. Phytochemistry 65:1937-1954, 2004.
    • (2004) Phytochemistry , vol.65 , pp. 1937-1954
    • Jolad, S.D.1    Lantz, R.C.2    Solyom, A.M.3
  • 2
    • 23844530273 scopus 로고    scopus 로고
    • Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles
    • Chrubasik S, Pittler MH, and Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12:684-701, 2005.
    • (2005) Phytomedicine , vol.12 , pp. 684-701
    • Chrubasik, S.1    Pittler, M.H.2    Roufogalis, B.D.3
  • 3
    • 22444431608 scopus 로고    scopus 로고
    • Ginger: An herbal medicinal product with anti-inflammatory actions
    • Grzanna R, Lindmark L, and Frondoza CG. Ginger: An herbal medicinal product with anti-inflammatory actions. J Med Food 8:125-132, 2005.
    • (2005) J Med Food , vol.8 , pp. 125-132
    • Grzanna, R.1    Lindmark, L.2    Frondoza, C.G.3
  • 4
    • 0021679209 scopus 로고
    • Pharmacological studies on ginger: I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol
    • Suekawa M, Ishige A, Yuasa K, et al. Pharmacological studies on ginger: I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 7:836-848, 1984.
    • (1984) J Pharmacobiodyn , vol.7 , pp. 836-848
    • Suekawa, M.1    Ishige, A.2    Yuasa, K.3
  • 5
    • 28844485665 scopus 로고    scopus 로고
    • Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages
    • Kim HW, Murakami A, Abe M, et al. Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages. Antioxid Redox Signal 7:1621-1629, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1621-1629
    • Kim, H.W.1    Murakami, A.2    Abe, M.3
  • 6
    • 9644273866 scopus 로고    scopus 로고
    • Analgesic and antiinflammatory activities of [6]-gingerol
    • Young HY, Luo YL, Cheng HY, et al. Analgesic and antiinflammatory activities of [6]-gingerol. J Ethnopharmacol 96:207-210, 2005.
    • (2005) J Ethnopharmacol , vol.96 , pp. 207-210
    • Young, H.Y.1    Luo, Y.L.2    Cheng, H.Y.3
  • 7
    • 23744431584 scopus 로고    scopus 로고
    • 6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo
    • Kim EC, Min JK, Kim TY, et al. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 335:300-308, 2005.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 300-308
    • Kim, E.C.1    Min, J.K.2    Kim, T.Y.3
  • 8
    • 0010938278 scopus 로고    scopus 로고
    • Expression and regulation of MUC8 and MUC5AC by various cytokines in normal human nasal epithelial cells
    • Lee JG, Moon HJ, Kim SS, et al. Expression and regulation of MUC8 and MUC5AC by various cytokines in normal human nasal epithelial cells. Korean J Otolaryngol 44:600-605, 2001.
    • (2001) Korean J Otolaryngol , vol.44 , pp. 600-605
    • Lee, J.G.1    Moon, H.J.2    Kim, S.S.3
  • 9
    • 1642581818 scopus 로고    scopus 로고
    • Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia
    • Gray T, Coakley R, Hirsh A, et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol 286:L320-L330, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Gray, T.1    Coakley, R.2    Hirsh, A.3
  • 10
    • 0037593635 scopus 로고    scopus 로고
    • Interleukin-1β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells
    • Song KS, Lee WJ, Chung KC, et al. Interleukin-1β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 278:23243-23250, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 23243-23250
    • Song, K.S.1    Lee, W.J.2    Chung, K.C.3
  • 11
    • 0029825959 scopus 로고    scopus 로고
    • Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells
    • Kai H, Yoshitake K, Hisatsune A, et al. Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells. Am J Physiol 271:L484-L488, 1996.
    • (1996) Am J Physiol , vol.271
    • Kai, H.1    Yoshitake, K.2    Hisatsune, A.3
  • 12
    • 70349228591 scopus 로고    scopus 로고
    • Budesonide down-regulates IL-1β-mediated MUC2/MUC5AC genes expression and mucin secretion in human airway epithelial cells
    • Kim YD, Cho JS, Chang KY, et al. Budesonide down-regulates IL-1β-mediated MUC2/MUC5AC genes expression and mucin secretion in human airway epithelial cells. Korean J Otolaryngol 45:873-877, 2002.
    • (2002) Korean J Otolaryngol , vol.45 , pp. 873-877
    • Kim, Y.D.1    Cho, J.S.2    Chang, K.Y.3
  • 13
    • 0033624132 scopus 로고    scopus 로고
    • Regulation of IL-1β-mediated MUC2 gene in NCI-H292 human airway epithelial cells
    • Kim YD, Kwon EJ, Kwon TK, et al. Regulation of IL-1β-mediated MUC2 gene in NCI-H292 human airway epithelial cells. Biochem Biophys Res Commun 274:112-116, 2000.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 112-116
    • Kim, Y.D.1    Kwon, E.J.2    Kwon, T.K.3
  • 14
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, and Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71:1397-1421, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 15
    • 29144435210 scopus 로고    scopus 로고
    • Molecular targets of dietary polyphenols with anti-inflammatory properties
    • Yoon JH, and Baek SJ. Molecular targets of dietary polyphenols with anti-inflammatory properties. J Yonsei Med 46: 585-596, 2005.
    • (2005) J Yonsei Med , vol.46 , pp. 585-596
    • Yoon, J.H.1    Baek, S.J.2
  • 16
    • 0032813348 scopus 로고    scopus 로고
    • Molecular mechanism of chemopreventive effects of selected dietary and medicinal phenolic substances
    • Surh YJ. Molecular mechanism of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res 428:305-327, 1999.
    • (1999) Mutat Res , vol.428 , pp. 305-327
    • Surh, Y.J.1
  • 17
    • 0025109806 scopus 로고
    • Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro
    • Goto C, Kasuya S, Koga K, et al. Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. Parasitol Res 76:653-656, 1990.
    • (1990) Parasitol Res , vol.76 , pp. 653-656
    • Goto, C.1    Kasuya, S.2    Koga, K.3
  • 18
    • 0035110888 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol
    • Bode AM, Ma WY, Surh YJ, et al. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Can Res 61:850-853, 2001.
    • (2001) Can Res , vol.61 , pp. 850-853
    • Bode, A.M.1    Ma, W.Y.2    Surh, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.