Modulation of leptin levels by oxidized linoleic acid: A connection to atherosclerosis?

Journal of Medicinal Food

Volumn 14, Issue 4, 2011, Pages 441-443

  Penumetcha, Meera ^a   Merchant, Nadya ^b   Parthasarathy, Sampath ^c  

^a GEORGIA STATE UNIVERSITY   (United States)

^b InVasc Therapeutics   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

dietary oxidized fat; food efficiency; obesity

Indexed keywords

LEPTIN; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LINOLEIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ATHEROSCLEROSIS; ARTICLE; CALORIC INTAKE; CHOLESTEROL DIET; CONTROLLED STUDY; HORMONAL REGULATION; HORMONE BLOOD LEVEL; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AORTA; ATHEROSCLEROSIS; CHOLESTEROL, DIETARY; CHOLESTEROL, LDL; LEPTIN; LINOLEIC ACID; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MICE; MICE, KNOCKOUT; OBESITY; OXIDATIVE STRESS; RECEPTORS, LDL; TRIGLYCERIDES;

ANIMALIA; MUS;

EID: 79953214604     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.0059     Document Type: Article

References (30)

1. Maffei M, Halaas J, Ravussin E, et al.: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-1161.
2. Friedman JM: Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 2009;89:973S-979S.
3. Considine RV: Regulation of leptin production. Rev Endocr Metab Disord 2001;2:357-363. (Pubitemid 33640584)
4. Considine RV, Sinha MK, Heiman ML, et al.: Serum immunoreactive- leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295. (Pubitemid 26033933)
5. Pelleymounter MA, Cullen MJ, Healy D, Hecht R, Winters D, McCaleb M: Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice. Am J Physiol 1998;275:R950-R959.
6. Van Heek M, Compton DS, France CF, et al.: Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 1997;99:385-390. (Pubitemid 27414794)
7. Yudkin JS, Yajnik CS, Mohamed-Ali V, Bulmer K: High levels of circulating proinflammatory cytokines and leptin in urban, but not rural, Indians. A potential explanation for increased risk of diabetes and coronary heart disease. Diabetes Care 1999;22:363-364.
8. Leyva F, Godsland IF, Ghatei M, et al.: Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol 1998;18:928-933. (Pubitemid 28272587)
9. Wallace AM, McMahon AD, Packard CJ, et al.: Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 2001;104: 3052-3056. (Pubitemid 34014056)
10. Gomez-Ambrosi J, Salvador J, Paramo JA, et al.: Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem 2002;35:315-320. (Pubitemid 34804903)
11. van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW: Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 2001;25:1759-1766. (Pubitemid 33131915)
12. Beltowski J: Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 2006;24:789-801. (Pubitemid 43670444)
13. Knudson JD, Dincer UD, Zhang C, et al.: Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. Am J Physiol Heart Circ Physiol 2005;289:H48-H56. (Pubitemid 40934081)
14. Couillard C, Lamarche B, Mauriege P, et al.: Leptinemia is not a risk factor for ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Diabetes Care 1998;21: 782-786. (Pubitemid 28487071)
15. Chiba T, Shinozaki S, Nakazawa T, et al.: Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice. Atherosclerosis 2008;196:68-75.
16. Yla-Herttuala S, Palinski W, Rosenfeld ME, et al.: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84: 1086-1095. (Pubitemid 19247577)
17. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924. (Pubitemid 19101597)
18. Khan-Merchant N, Penumetcha M, Meilhac O, Parthasarathy S: Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. J Nutr 2002;132:3256-3262. (Pubitemid 35304230)
19. Auerbach BJ, Kiely JS, Cornicelli JA: A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. Anal Biochem 1992;201:375-380.
20. Tamer L, Ercan B, Unlu A, et al.: The relationship between leptin and lipids in atherosclerosis. Indian Heart J 2002;54:692-696. (Pubitemid 36362959)
21. Aguilera A, Bajo MA, Rebollo F, et al.: Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. Adv Perit Dial 2002;18:212-217.
22. Koh KK, Park SM, Quon MJ: Leptin and cardiovascular disease: response to therapeutic interventions. Circulation 2008;117: 3238-3249.
23. Cammisotto PG, Gelinas Y, Deshaies Y, Bukowiecki LJ: Regulation of leptin secretion from white adipocytes by free fatty acids. Am J Physiol Endocrinol Metab 2003;285:E521-E526. (Pubitemid 37010829)
24. Kratz M, von Eckardstein A, Fobker M, et al.: The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. J Clin Endocrinol Metab 2002;87: 5008-5014. (Pubitemid 35316339)
25. Peyron-Caso E, Taverna M, Guerre-Millo M, et al.: Dietary (n-3) polyunsaturated fatty acids up-regulate plasma leptin in insulinresistant rats. J Nutr 2002;132:2235-2240. (Pubitemid 34851656)
26. Reseland JE, Haugen F, Hollung K, et al.: Reduction of leptin gene expression by dietary polyunsaturated fatty acids. J Lipid Res 2001;42:743-750. (Pubitemid 32509598)
27. Fukuda H, Iritani N: Transcriptional regulation of leptin gene promoter in rat. FEBS Lett 1999;455:165-169. (Pubitemid 29322803)
28. Winnicki M, Somers VK, Accurso V, et al.: Fish-rich diet, leptin, and body mass. Circulation 2002;106:289-291. (Pubitemid 34778948)
29. Penumetcha M, Khan N, Parthasarathy S: Dietary oxidized fatty acids: an atherogenic risk? J Lipid Res 2000;41:1473-1480.
30. Itoh T, Fairall L, Amin K, et al.: Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol 2008;15:924-931.