Dietary oxidized fatty acids: An atherogenic risk?

Journal of Lipid Research

Volumn 41, Issue 9, 2000, Pages 1473-1480

  Penumetcha, M ^a   Khan, N ^a   Parthasarathy, S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Brush border; Chylomicron; Lipid absorption; Oxidized low density lipoprotein; Smooth muscle cells

Indexed keywords

LOW DENSITY LIPOPROTEIN;

APOPTOSIS; ARTICLE; ATHEROGENESIS; BRUSH BORDER; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN CACO 2; CORONARY RISK; ESTERIFICATION; FAT INTAKE; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; LIPID ABSORPTION; LIPID OXIDATION; LIVER MICROSOME; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ACYLTRANSFERASES; ALKALINE PHOSPHATASE; ANIMAL; ARTERIOSCLEROSIS; BIOLOGICAL TRANSPORT; DIETARY FATS; HUMAN; INTESTINAL MUCOSA; INTESTINES; LINOLEIC ACIDS; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSOMES; MICROVILLI; MUSCLE, SMOOTH; OLEIC ACID; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0033796526     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Cytotoxicity and genotoxicity of lipid-oxidation products
2. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture
3. Activation of human blood monocytes by oxidized polyunsaturated fatty acids: A possible mechanism for the generation of lipid peroxides in the circulation
4. Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration
5. Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration
6. Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells
7. Role of hydroperoxyeicosatetraenoic acids in the oxidative stress-induced activating protein-1 (AP-1) activity
8. Linoleic acid and its metabolite, hydroeicosatetraenoic acid, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein, protein kinase activation, and growth in rat aortic smooth muscle cells
9. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells
10. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells
11. Regulation of endothelial nitric oxide synthetase gene expression by oxidized linoleic acid
12. Lipid hydroperoxide-induced apoptosis: Lack of inhibition by Bcl-2 over-expression
13. Induction of interleukin-1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroeicosatetraenoic acid
14. Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells
15. Inhibition of rabbit platelet activation by lipoxygenase products of arachidonic and linoleic acid
16. Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells
17. Evidence that angiotensin II and lipoxygenase products activate c-Jun NH2-terminal kinase
18. Structural and dynamic effects of oxidatively modified phospholipids in unsaturated lipid membranes
19. Oxidatively fragmented phospholipids as inflammatory mediators: The dark side of polyunsaturated lipids
20. Phospholipid hydroperoxides are precursors of lipid alkoxyl radicals produced from anoxia/reoxygenated endothelial cells
21. Linoleic acid hydroperoxide-induced peroxidation of endothelial cell phospholipids and cytotoxicity
22. Phospholipid peroxidation in tumor promoter-exposed mouse skin
23. Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells
24. Association of negatively-charged phospholipids with low-density lipoprotein (LDL) increases its uptake and the deposition of cholesteryl esters by macrophages
25. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
26. 7 Beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein
27. Lipoxygenase-mediated transformation of human low density, lipoprotein to an oxidized and cytotoxic complex
28. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
29. The effect of oxidized lipids in the diet on serum lipoprotein peroxides in control and diabetic rats
30. Effect of dietary lipid peroxides on metabolism of serum chylomicrons in rats
31. Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats
32. Uptake of 13-hydroperoxylinoleic acid by cultured cells
33. Intestinal absorption of lipids
34. Lipid digestion and absorption
35. The micellar hypothesis of fat absorption: Must it be revisited?
36. Cytochemistry of fat absorption, 1984
37. Evidence for a concerted reaction between lipid hydroperoxides and polypeptides
38. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid
39. Rapid method for total lipid extraction and purification
40. Effects of sodium butyrate and dimethyl-sulfoxide on biochemical properties of human colon cancer cells
41. Inhibition of diacylglycerol; CDP choline cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxy acetate
42. Modulation of phosphatidylcholine synthesis in vitro. Inhibition of diacylglycerol cholinephosphotransferase and lysophosphatidylcholine acyl transferase by cetrophenoxine and neophenoxine
43. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface
44. Imaging cultured cells on protein coated silicon chips using low voltage in-lens SEM
45. Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines