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Volumn 60, Issue 4, 2011, Pages 1324-1328

Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; DIAZOXIDE; ENSURE; GLIMEPIRIDE; GLUCAGON; GLUCOSE; INSULIN; NORADRENALIN; PLACEBO;

EID: 79953209697     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1586     Document Type: Article
Times cited : (5)

References (27)
  • 1
    • 67349228410 scopus 로고    scopus 로고
    • The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality
    • Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009;52:1003-1012
    • (2009) Diabetologia , vol.52 , pp. 1003-1012
    • Kahn, S.E.1    Zraika, S.2    Utzschneider, K.M.3    Hull, R.L.4
  • 2
    • 77954323314 scopus 로고    scopus 로고
    • The stunned beta cell: A brief history
    • Ferrannini E. The stunned beta cell: a brief history. Cell Metab 2010;11:349-352
    • (2010) Cell Metab , vol.11 , pp. 349-352
    • Ferrannini, E.1
  • 4
    • 34250307235 scopus 로고    scopus 로고
    • A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
    • MacDonald PE, De Marinis YZ, Ramracheya R, et al. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007;5:e143
    • (2007) PLoS Biol , vol.5
    • MacDonald, P.E.1    De Marinis, Y.Z.2    Ramracheya, R.3
  • 5
    • 33846856711 scopus 로고    scopus 로고
    • α-cells of the endocrine pancreas: 35 years of research but the enigma remains
    • DOI 10.1210/er.2006-0007
    • Gromada J, Franklin I, Wollheim CB. α-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007;28:84-116 (Pubitemid 46220851)
    • (2007) Endocrine Reviews , vol.28 , Issue.1 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 6
    • 0021711003 scopus 로고
    • Insulin within islets is a physiologic glucagon release inhibitor
    • Maruyama H, Hisatomi A, Orci L, Grodsky GM, Unger RH. Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest 1984;74:2296-2299 (Pubitemid 15197376)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.6 , pp. 2296-2299
    • Maruyama, H.1    Hisatomi, A.2    Orci, L.3
  • 7
    • 0023820363 scopus 로고
    • The order of islet microsvascular cellular perfusion is B - A - D in the perfused rat pancreas
    • Samols E, Stagner JI, Ewart RBL, Marks V. The order of islet microvascular cellular perfusion is B - A - D in the perfused rat pancreas. J Clin Invest 1988;82:350-353 (Pubitemid 18262537)
    • (1988) Journal of Clinical Investigation , vol.82 , Issue.1 , pp. 350-353
    • Samols, E.1    Stagner, J.I.2    Ewart, R.B.L.3    Marks, V.4
  • 8
    • 0034801880 scopus 로고    scopus 로고
    • Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas
    • DOI 10.1097/00006676-200110000-00012
    • Brunicardi FC, Kleinman R, Moldovan S, et al. Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas. Pancreas 2001;23:302-308 (Pubitemid 32910980)
    • (2001) Pancreas , vol.23 , Issue.3 , pp. 302-308
    • Brunicardi, F.C.1    Kleinman, R.2    Moldovan, S.3    Nguyen, T.-H.L.4    Watt, P.C.5    Walsh, J.6    Gingerich, R.7
  • 9
    • 2542532408 scopus 로고    scopus 로고
    • Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: The "switch-off" hypothesis
    • Zhou H, Tran PO, Yang S, et al. Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes 2004;53:1482-1487
    • (2004) Diabetes , vol.53 , pp. 1482-1487
    • Zhou, H.1    Tran, P.O.2    Yang, S.3
  • 10
    • 63249127193 scopus 로고    scopus 로고
    • Somatostatin secreted by islet δ-cells fulfills multiple roles as a paracrine regulator of islet function
    • Hauge-Evans AC, King AJ, Carmignac D, et al. Somatostatin secreted by islet δ-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 2009;58:403-411
    • (2009) Diabetes , vol.58 , pp. 403-411
    • Hauge-Evans, A.C.1    King, A.J.2    Carmignac, D.3
  • 11
    • 2642593026 scopus 로고    scopus 로고
    • Autonomic mediation of glucagon secretion during hypoglycemia: Implications for impaired alpha-cell responses in type 1 diabetes
    • DOI 10.2337/diabetes.47.7.995
    • Taborsky GJ Jr, Ahrén B, Havel PJ. Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes. Diabetes 1998;47:995-1005 (Pubitemid 28294539)
    • (1998) Diabetes , vol.47 , Issue.7 , pp. 995-1005
    • Taborsky Jr., G.J.1    Ahren, B.2    Havel, P.J.3
  • 12
    • 34548207654 scopus 로고    scopus 로고
    • Brain glucose sensing, counter-regulation, and energy homeostasis
    • Bethesda
    • Marty N, Dallaporta M, Thorens B. Brain glucose sensing, counter-regulation, and energy homeostasis. Physiology (Bethesda) 2007;22:241-251
    • (2007) Physiology , vol.22 , pp. 241-251
    • Marty, N.1    Dallaporta, M.2    Thorens, B.3
  • 13
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87:1409-1439 (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 14
    • 33745301045 scopus 로고    scopus 로고
    • Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: Further evidence for the intraislet insulin hypothesis
    • DOI 10.2337/diabetes.55.04.06.db05-1449
    • Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes 2006;55:1051-1056 (Pubitemid 44100181)
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1051-1056
    • Meier, J.J.1    Kjems, L.L.2    Veldhuis, J.D.3    Lefebvre, P.4    Butler, P.C.5
  • 15
    • 56049086867 scopus 로고    scopus 로고
    • Insulin as a physiological modulator of glucagon secretion
    • Bansal P, Wang Q. Insulin as a physiological modulator of glucagon secretion. Am J Physiol Endocrinol Metab 2008;295:E751-E761
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Bansal, P.1    Wang, Q.2
  • 16
    • 78049300087 scopus 로고    scopus 로고
    • Insulin reciprocally regulates glucagon secretion in humans
    • Cooperberg BA, Cryer PE. Insulin reciprocally regulates glucagon secretion in humans. Diabetes 2010;59:2936-2940
    • (2010) Diabetes , vol.59 , pp. 2936-2940
    • Cooperberg, B.A.1    Cryer, P.E.2
  • 17
    • 0036227054 scopus 로고    scopus 로고
    • Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
    • Banarer S, McGregor VP, Cryer PE. Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 2002;51:958-965 (Pubitemid 34438337)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 958-965
    • Banarer, S.1    McGregor, V.P.2    Cryer, P.E.3
  • 18
    • 14644439841 scopus 로고    scopus 로고
    • Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: Documentation of the intraislet insulin hypothesis in humans
    • DOI 10.2337/diabetes.54.3.757
    • Raju B, Cryer PE. Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. Diabetes 2005;54:757-764 (Pubitemid 40322079)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 757-764
    • Raju, B.1    Cryer, P.E.2
  • 19
    • 18144396132 scopus 로고    scopus 로고
    • Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans
    • DOI 10.2337/diacare.28.5.1124
    • Gosmanov NR, Szoke E, Israelian Z, et al. Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. Diabetes Care 2005;28:1124-1131 (Pubitemid 40616623)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1124-1131
    • Gosmanov, N.R.1    Szoke, E.2    Israelian, Z.3    Smith, T.4    Cryer, P.E.5    Gerich, J.E.6    Meyer, C.7
  • 20
    • 33644684529 scopus 로고    scopus 로고
    • Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes
    • DOI 10.2337/diacare.28.11.2691
    • Israelian Z, Gosmanov NR, Szoke E, et al. Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. Diabetes Care 2005;28:2691-2696 (Pubitemid 43951161)
    • (2005) Diabetes Care , vol.28 , Issue.11 , pp. 2691-2696
    • Israelian, Z.1    Gosmanov, N.R.2    Szoke, E.3    Schorr, M.4    Bokhari, S.5    Cryer, P.E.6    Gerich, J.E.7    Meyer, C.8
  • 21
    • 72249093748 scopus 로고    scopus 로고
    • β-cell-mediated signaling predominates over direct α-cell signaling in the regulation of glucagon secretion in humans
    • Cooperberg BA, Cryer PE. β-cell-mediated signaling predominates over direct α-cell signaling in the regulation of glucagon secretion in humans. Diabetes Care 2009;32:2275-2280
    • (2009) Diabetes Care , vol.32 , pp. 2275-2280
    • Cooperberg, B.A.1    Cryer, P.E.2
  • 22
    • 0022189557 scopus 로고
    • External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine
    • Shah SD, Clutter WE, Cryer PE. External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine. J Lab Clin Med 1985;106:624-629 (Pubitemid 16032502)
    • (1985) Journal of Laboratory and Clinical Medicine , vol.106 , Issue.6 , pp. 624-629
    • Shah, S.D.1    Clutter, W.E.2    Cryer, P.E.3
  • 23
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion
    • Müller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 1970;283:109-115
    • (1970) N Engl J Med , vol.283 , pp. 109-115
    • Müller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 24
    • 0023109225 scopus 로고
    • Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus
    • Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987;64:106-110 (Pubitemid 17015886)
    • (1987) Journal of Clinical Endocrinology and Metabolism , vol.64 , Issue.1 , pp. 106-110
    • Reaven, G.M.1    Chen, Y.-D.I.2    Golay, A.3
  • 26
    • 34250854205 scopus 로고    scopus 로고
    • The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    • DOI 10.1210/er.2006-0026
    • Dunning BE, Gerich JE. The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007;28:253-283 (Pubitemid 46984828)
    • (2007) Endocrine Reviews , vol.28 , Issue.3 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 27
    • 34249858600 scopus 로고    scopus 로고
    • Fasting hyperglycemia impairs glucose- But not insulin-mediated suppression of glucagon secretion
    • DOI 10.1210/jc.2006-1515
    • Abdul-Ghani M, DeFronzo RA. Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion. J Clin Endocrinol Metab 2007;92:1778-1784 (Pubitemid 46997188)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.5 , pp. 1778-1784
    • Abdul-Ghani, M.1    DeFronzo, R.A.2


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