-
1
-
-
0014776021
-
Studies of pancreatic alpha cell function in normal and diabetic subjects
-
Unger RH, Aguilar-Parada E, Muller WA, Eisentraut AM: Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 49:837-848, 1970
-
(1970)
J Clin Invest
, vol.49
, pp. 837-848
-
-
Unger, R.H.1
Aguilar-Parada, E.2
Muller, W.A.3
Eisentraut, A.M.4
-
2
-
-
0017564902
-
Role of glucagon in diabetes
-
Unger RH, Orci L: Role of glucagon in diabetes. Arch Intern Med 137:482-491, 1977
-
(1977)
Arch Intern Med
, vol.137
, pp. 482-491
-
-
Unger, R.H.1
Orci, L.2
-
3
-
-
0029035354
-
Glucagon and its family revisited
-
Lefebvre PJ: Glucagon and its family revisited. Diabetes Care 18:715-730, 1995
-
(1995)
Diabetes Care
, vol.18
, pp. 715-730
-
-
Lefebvre, P.J.1
-
4
-
-
0017233254
-
Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects
-
Sherwin RS, Fisher M, Hendler R, Felig P: Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med 294:455-461, 1976
-
(1976)
N Engl J Med
, vol.294
, pp. 455-461
-
-
Sherwin, R.S.1
Fisher, M.2
Hendler, R.3
Felig, P.4
-
5
-
-
0018122474
-
Hyperglucagonemia and its suppression: Importance in the metabolic control of diabetes
-
Raskin P, Unger RH: Hyperglucagonemia and its suppression: importance in the metabolic control of diabetes. N Engl J Med 299:433-436, 1978
-
(1978)
N Engl J Med
, vol.299
, pp. 433-436
-
-
Raskin, P.1
Unger, R.H.2
-
6
-
-
0026602267
-
Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
-
Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992
-
(1992)
N Engl J Med
, vol.326
, pp. 22-29
-
-
Mitrakou, A.1
Kelley, D.2
Mokan, M.3
Veneman, T.4
Pangburn, T.5
Reilly, J.6
Gerich, J.7
-
7
-
-
76549198972
-
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
-
Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633, 1965
-
(1965)
Diabetes
, vol.14
, pp. 619-633
-
-
Gepts, W.1
-
8
-
-
0023618080
-
Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy
-
Lohr M, Kloppel G: Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia 30:757-762, 1987
-
(1987)
Diabetologia
, vol.30
, pp. 757-762
-
-
Lohr, M.1
Kloppel, G.2
-
9
-
-
0027078251
-
Pancreatic beta cells in insulin-dependent diabetes
-
Pipeleers D, Ling Z: Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 8:209-227, 1992
-
(1992)
Diabetes Metab Rev
, vol.8
, pp. 209-227
-
-
Pipeleers, D.1
Ling, Z.2
-
10
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
11
-
-
27744603796
-
Sustained beta-cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
-
Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC: Sustained beta-cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221-2228, 2005
-
(2005)
Diabetologia
, vol.48
, pp. 2221-2228
-
-
Meier, J.J.1
Bhushan, A.2
Butler, A.E.3
Rizza, R.A.4
Butler, P.C.5
-
12
-
-
0018191318
-
Prevalence of residual beta-cell function in insulin-dependent diabetics in relation to age at onset and duration of diabetes
-
Madsbad S, Faber OK, Binder C, McNair P, Christiansen C, Transbol I: Prevalence of residual beta-cell function in insulin-dependent diabetics in relation to age at onset and duration of diabetes. Diabetes 27:262-264, 1978
-
(1978)
Diabetes
, vol.27
, pp. 262-264
-
-
Madsbad, S.1
Faber, O.K.2
Binder, C.3
McNair, P.4
Christiansen, C.5
Transbol, I.6
-
13
-
-
0023916553
-
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus
-
Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, Van Cauter E: Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318:1231-1239, 1988
-
(1988)
N Engl J Med
, vol.318
, pp. 1231-1239
-
-
Polonsky, K.S.1
Given, B.D.2
Hirsch, L.J.3
Tillil, H.4
Shapiro, E.T.5
Beebe, C.6
Frank, B.H.7
Galloway, J.A.8
Van Cauter, E.9
-
14
-
-
14644439841
-
Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: Documentation of the intraislet insulin hypothesis in humans
-
Raju B, Cryer PE: Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. Diabetes 54:757-764, 2005
-
(2005)
Diabetes
, vol.54
, pp. 757-764
-
-
Raju, B.1
Cryer, P.E.2
-
15
-
-
0009446583
-
Glucagon and diabetes
-
Lefèbvre P, Ed. Berlin, Springer-Verlag
-
Lefèbvre PJ: Glucagon and diabetes. In Glucagon III: Handbook of Experimental Pharmacology. Vol. 123. Lefèbvre P, Ed. Berlin, Springer-Verlag, 1996, p.115-131
-
(1996)
Glucagon III: Handbook of Experimental Pharmacology
, vol.123
, pp. 115-131
-
-
Lefèbvre, P.J.1
-
16
-
-
2542622239
-
Regulation of α-cell function by the β-cell in isolated human and rat islets deprived of glucose: The "switch-off" hypothesis
-
Hope KM, Tran PO, Zhou H, Oseid E, Leroy E, Robertson RP: Regulation of α-cell function by the β-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. Diabetes 53:1488-1495, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1488-1495
-
-
Hope, K.M.1
Tran, P.O.2
Zhou, H.3
Oseid, E.4
Leroy, E.5
Robertson, R.P.6
-
17
-
-
0035461929
-
Decrease in β-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig
-
Kjems LL, Kirby BM, Welsh EM, Veldhuis JD, Straume M, McIntyre SS, Yang D, Lefebvre P, Butler PC: Decrease in β-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 50:2001-2012, 2001
-
(2001)
Diabetes
, vol.50
, pp. 2001-2012
-
-
Kjems, L.L.1
Kirby, B.M.2
Welsh, E.M.3
Veldhuis, J.D.4
Straume, M.5
McIntyre, S.S.6
Yang, D.7
Lefebvre, P.8
Butler, P.C.9
-
18
-
-
0026724547
-
Deconvolution analysis of hormone data
-
Veldhuis JD, Johnson ML: Deconvolution analysis of hormone data. Methods Enzymol 210:539-575, 1992
-
(1992)
Methods Enzymol
, vol.210
, pp. 539-575
-
-
Veldhuis, J.D.1
Johnson, M.L.2
-
19
-
-
0041464620
-
Differential regional metabolism of glucagon in anesthetized pigs
-
Deacon CF, Kelstrup M, Trebbien R, Klarskov L, Olesen M, Holst JJ: Differential regional metabolism of glucagon in anesthetized pigs. Am J Physiol Endocrinol Metab 285:E551-E560, 2003
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Deacon, C.F.1
Kelstrup, M.2
Trebbien, R.3
Klarskov, L.4
Olesen, M.5
Holst, J.J.6
-
20
-
-
0028814801
-
Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting
-
Porksen N, Munn S, Steers J, Vore S, Veldhuis J, Butler P: Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am J Physiol 269:E478-E488, 1995
-
(1995)
Am J Physiol
, vol.269
-
-
Porksen, N.1
Munn, S.2
Steers, J.3
Vore, S.4
Veldhuis, J.5
Butler, P.6
-
21
-
-
0026015905
-
Approximate entropy as a measure of system complexity
-
Pincus SM: Approximate entropy as a measure of system complexity. Proc Natl Acad Sci U S A 88:2297-2301, 1991
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 2297-2301
-
-
Pincus, S.M.1
-
22
-
-
21044438351
-
Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion
-
Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD: Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion. Am J Physiol Endocrinol Metab 289:E160-E165, 2005
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Liu, P.Y.1
Pincus, S.M.2
Keenan, D.M.3
Roelfsema, F.4
Veldhuis, J.D.5
-
23
-
-
12344289256
-
Analysis of bidirectional pattern synchrony of concentration-secretion pairs: Implementation in the human testicular and adrenal axes
-
Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD: Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes. Am J Physiol Regul Integr Comp Physiol 288:R440-R446, 2005
-
(2005)
Am J Physiol Regul Integr Comp Physiol
, vol.288
-
-
Liu, P.Y.1
Pincus, S.M.2
Keenan, D.M.3
Roelfsema, F.4
Veldhuis, J.D.5
-
24
-
-
0017357310
-
Insulin, glucagon, and glucose exhibit synchronous sustained oscillations in fasting monkeys
-
Goodner CJ, Walike BC, Koerker DJ, Ensinck JE, Brown AC, Chideckel EW, Palmer J, Kalnasy L: Insulin, glucagon, and glucose exhibit synchronous sustained oscillations in fasting monkeys. Science 195:177-179, 1977
-
(1977)
Science
, vol.195
, pp. 177-179
-
-
Goodner, C.J.1
Walike, B.C.2
Koerker, D.J.3
Ensinck, J.E.4
Brown, A.C.5
Chideckel, E.W.6
Palmer, J.7
Kalnasy, L.8
-
25
-
-
0024804289
-
Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons
-
Goodner CJ, Koerker DJ, Weigle DS, McCulloch DK: Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons. Diabetes 38:925-931, 1989
-
(1989)
Diabetes
, vol.38
, pp. 925-931
-
-
Goodner, C.J.1
Koerker, D.J.2
Weigle, D.S.3
McCulloch, D.K.4
-
26
-
-
0023226183
-
Pulsatility of insulin and glucagon release: Physiological significance and pharmacological implications
-
Lefebvre PJ, Paolisso G, Scheen AJ, Henquin JC: Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications. Diabetologia 30:443-452, 1987
-
(1987)
Diabetologia
, vol.30
, pp. 443-452
-
-
Lefebvre, P.J.1
Paolisso, G.2
Scheen, A.J.3
Henquin, J.C.4
-
27
-
-
0028814801
-
Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting
-
Pørksen N, Munn S, Steers J, Vore S, Veldhuis JD, Butler PC: Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am J Physiol 269:E478-E488, 1995
-
(1995)
Am J Physiol
, vol.269
-
-
Pørksen, N.1
Munn, S.2
Steers, J.3
Vore, S.4
Veldhuis, J.D.5
Butler, P.C.6
-
28
-
-
0029797907
-
Effects of somatostatin on pulsatile insulin secretion: Selective inhibition of insulin burst mass
-
Pørksen N, Munn SR, Steers JL, Veldhuis JD, Butler PC: Effects of somatostatin on pulsatile insulin secretion: selective inhibition of insulin burst mass. Am J Physiol (Endocrinol Metab) 270:E1043-E1049, 1996
-
(1996)
Am J Physiol (Endocrinol Metab)
, vol.270
-
-
Pørksen, N.1
Munn, S.R.2
Steers, J.L.3
Veldhuis, J.D.4
Butler, P.C.5
-
29
-
-
0029959109
-
Mechanisms of sulfonylurea's stimulation of insulin secretion in vivo: Selective amplification of insulin secretory burst mass
-
Pørksen NK, Munn SR, Steers JL, Schmitz O, Veldhuis JD, Butler PC: Mechanisms of sulfonylurea's stimulation of insulin secretion in vivo: selective amplification of insulin secretory burst mass. Diabetes 45:1792-1797, 1996
-
(1996)
Diabetes
, vol.45
, pp. 1792-1797
-
-
Pørksen, N.K.1
Munn, S.R.2
Steers, J.L.3
Schmitz, O.4
Veldhuis, J.D.5
Butler, P.C.6
-
30
-
-
0015901935
-
Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect
-
Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH: Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 182:171-173, 1973
-
(1973)
Science
, vol.182
, pp. 171-173
-
-
Gerich, J.E.1
Langlois, M.2
Noacco, C.3
Karam, J.H.4
Forsham, P.H.5
-
31
-
-
0023820363
-
The order of islet microvascular cellular perfusion is B - A - D in the perfused rat pancreas
-
Samols E, Stagner JI, Ewart RB, Marks V: The order of islet microvascular cellular perfusion is B - A - D in the perfused rat pancreas. J Clin Invest 82:350-353, 1988
-
(1988)
J Clin Invest
, vol.82
, pp. 350-353
-
-
Samols, E.1
Stagner, J.I.2
Ewart, R.B.3
Marks, V.4
-
32
-
-
0036314189
-
Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
-
Segel SA, Paramore DS, Cryer PE: Hypoglycemia-associated autonomic failure in advanced type 2 diabetes. Diabetes 51:724-733, 2002
-
(2002)
Diabetes
, vol.51
, pp. 724-733
-
-
Segel, S.A.1
Paramore, D.S.2
Cryer, P.E.3
-
33
-
-
0036227054
-
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
-
Banarer S, McGregor VP, Cryer PE: Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 51:958-965, 2002
-
(2002)
Diabetes
, vol.51
, pp. 958-965
-
-
Banarer, S.1
McGregor, V.P.2
Cryer, P.E.3
-
34
-
-
2542532408
-
Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: The "switch-off" hypothesis
-
Zhou H, Tran PO, Yang S, Zhang T, LeRoy E, Oseid E, Robertson RP: Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes 53:1482-1487, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1482-1487
-
-
Zhou, H.1
Tran, P.O.2
Yang, S.3
Zhang, T.4
LeRoy, E.5
Oseid, E.6
Robertson, R.P.7
-
35
-
-
0030658922
-
In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts
-
Pørksen N, Nyholm B, Veldhuis JD, Butler PC, Schmitz O: In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts. Am J Physiol 273:E908-E914, 1997
-
(1997)
Am J Physiol
, vol.273
-
-
Pørksen, N.1
Nyholm, B.2
Veldhuis, J.D.3
Butler, P.C.4
Schmitz, O.5
-
36
-
-
0029746149
-
Effects of glucose ingestion versus infusion on pulsatile insulin secretion: The incretin effect is achieved by amplification of insulin secretory burst mass
-
Pørksen N, Munn S, Steers J, Veldhuis JD, Butler PC: Effects of glucose ingestion versus infusion on pulsatile insulin secretion: the incretin effect is achieved by amplification of insulin secretory burst mass. Diabetes 45:1317-1323, 1996
-
(1996)
Diabetes
, vol.45
, pp. 1317-1323
-
-
Pørksen, N.1
Munn, S.2
Steers, J.3
Veldhuis, J.D.4
Butler, P.C.5
-
37
-
-
0034489574
-
Direct measurement of pulsatile insulin secretion from the portal vein in human subjects
-
Song SH, McIntyre SS, Shah H, Veldhuis JD, Hayes PC, Butler PC: Direct measurement of pulsatile insulin secretion from the portal vein in human subjects. J Clin Endocrinol Metab 85:4491-4499, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4491-4499
-
-
Song, S.H.1
McIntyre, S.S.2
Shah, H.3
Veldhuis, J.D.4
Hayes, P.C.5
Butler, P.C.6
-
38
-
-
0001922249
-
Anatomy of the islet of Langerhans
-
Samols E, Ed. New York, Raven
-
Bonner-Weir S: Anatomy of the islet of Langerhans. In The Endocrine Pancreas. Samols E, Ed. New York, Raven, 1991, p.15-27
-
(1991)
The Endocrine Pancreas
, pp. 15-27
-
-
Bonner-Weir, S.1
-
39
-
-
25844492048
-
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells
-
Diao J, Asghar Z, Chan CB, Wheeler MB: Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem 280:33487-33496, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 33487-33496
-
-
Diao, J.1
Asghar, Z.2
Chan, C.B.3
Wheeler, M.B.4
-
40
-
-
0016824048
-
Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics
-
Raskin P, Fujita Y, Unger RH: Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics. J Clin Invest 56:1132-1138, 1975
-
(1975)
J Clin Invest
, vol.56
, pp. 1132-1138
-
-
Raskin, P.1
Fujita, Y.2
Unger, R.H.3
-
41
-
-
0023948792
-
Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes
-
Paolisso G, Sgambato S, Torella R, Varrichio M, Scheen A, D'Onofrio F, Lefèbvre PJ: Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes. J Clin Endocrinol Metab 66:1220-1226,1988
-
(1988)
J Clin Endocrinol Metab
, vol.66
, pp. 1220-1226
-
-
Paolisso, G.1
Sgambato, S.2
Torella, R.3
Varrichio, M.4
Scheen, A.5
D'Onofrio, F.6
Lefèbvre, P.J.7
-
42
-
-
0031737728
-
2+ sensitivity in β-cells
-
2+ sensitivity in β-cells. Endocrinology 139:1133-1140, 1998
-
(1998)
Endocrinology
, vol.139
, pp. 1133-1140
-
-
Fujimoto, S.1
Ishida, H.2
Kato, S.3
Okamoto, Y.4
Tsuji, K.5
Mizuno, N.6
Ueda, S.7
Mukai, E.8
Seino, Y.9
-
43
-
-
20044394745
-
Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic α-cells
-
Ravier MA, Rutter GA: Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic α-cells. Diabetes 54:1789-1797, 2005
-
(2005)
Diabetes
, vol.54
, pp. 1789-1797
-
-
Ravier, M.A.1
Rutter, G.A.2
|