Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: A new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1906-1913

  Ma, Yan ^a,b   Ou, Tian Miao ^a   Tan, Jia Heng ^a   Hou, Jin Qiang ^a   Huang, Shi Liang ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Shunde Polytechnic   (China)

Author keywords

Berberine; Biophysical and biochemical evaluation; C myc G quadruplex; Quinolino benzo 5, 6 dihydroisoquindolium compounds; Synthesis

Indexed keywords

9 N 2' (N',N' DIMETHYLAMINO)ETHYLQUINOLINOBENZODIHYDROISOQUINDOLIUM; 9 N 3' (4 MORPHILINE)PROPYLQUINOLINOBENZODIHYDROISOQUINDOLIUM; 9 N 3' (N',N' DIMETHYLAMINO)ETHYLQUINOLINOBENZODIHYDROISOQUINDOLIUM; 9 N 6' AMINOHEXYLQUINOLINOBENZODIHYDROISOQUINDOLIUM; ANTINEOPLASTIC AGENT; BERBERINE; BERBERINE DERIVATIVE; GUANINE QUADRUPLEX; ISOQUINOLINE DERIVATIVE; PYRIDINE; QUINOLINOBENZO[5,6]DIHYDROISOQUINDOLIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN HL 60; CYTOTOXICITY; DOWN REGULATION; DRUG DNA BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; ONCOGENE C MYC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMODYNAMICS; THERMOSTABILITY; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BERBERINE; CELL PROLIFERATION; CELLS, CULTURED; DNA; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HL-60 CELLS; HUMANS; ISOQUINOLINES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-MYC; QUINOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEREOISOMERISM; THERMODYNAMICS; TRANSCRIPTION, GENETIC;

EID: 79953191076     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.020     Document Type: Article

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