Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11082-11090

  Pechtl, Isabell C ^a   Kavanagh, David ^b   Mcintosh, Nicola ^a   Harris, Claire L ^c   Barlow, Paul N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; C TERMINUS; COFACTOR ACTIVITY; COFACTORS; COMPLEMENT CONTROL PROTEINS; DATA SUPPORT; FLUID-PHASE; FUNCTIONAL PROPERTIES; GLOMERULAR CAPILLARIES; N-TERMINALS;

DISEASE CONTROL;

COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; ERYTHROCYTE; HEMOLYSIS; HEMOLYTIC UREMIC SYNDROME; HUMAN; MUTATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION;

AMINO ACID SUBSTITUTION; ANIMALS; COMPLEMENT C3B; COMPLEMENT FACTOR H; GENETIC DISEASES, INBORN; HEMOLYTIC-UREMIC SYNDROME; HUMANS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SHEEP;

EID: 79953190798     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.211839     Document Type: Article

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