Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Chai, Yongping ^a   Zhang, Dai Min ^a   Lin, Yu Fung ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALMODULIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; HYDROGEN PEROXIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; ZAPRINAST; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CATALASE; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL SEPARATION; CELL STRAIN HEK293; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; IN VITRO STUDY; KINETICS; METABOLISM; MOUSE; PATCH CLAMP; RABBIT; RAT;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; CATALASE; CELL SEPARATION; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; ION CHANNEL GATING; KATP CHANNELS; KINETICS; MICE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE INHIBITORS; RABBITS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 79953186454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018191     Document Type: Article

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