Dose-Dependent Switch in Response of Gonadotropin-Releasing Hormone (GnRH) Neurons to GnRH Mediated through the Type I GnRH Receptor

Endocrinology

Volumn 145, Issue 2, 2004, Pages 728-735

  Xu, Chun ^a   Xu, Xu Zhi ^a   Nunemaker, Craig S ^a   Moenter, Suzanne M ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADORELIN RECEPTOR; GONADORELIN RECEPTOR 1; GREEN FLUORESCENT PROTEIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BRAIN SLICE; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; GONADORELIN RELEASE; HYPOTHALAMUS; MOUSE; NERVE CELL; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GENE EXPRESSION; GONADOTROPIN-RELEASING HORMONE; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MALE; MICE; MICE, TRANSGENIC; NEURONS; ORCHIECTOMY; RECEPTORS, LHRH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0842334591     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0562     Document Type: Article

References (45)

1. Silverman AJ 1994 The gonadotropin-releasing hormone (GnRH) neuronal systems: immunocytochemistry and in situ hybridization. 2nd ed. New York: Raven Press, Ltd
2. King JC, Tobet SA, Snavely FL, Arimura AA 1982 LHRH immunopositive cells and their projections to the median eminence and organum vasculosum of the lamina terminalis. J Comp Neurol 209:287-300
3. Moenter SM, Brand RM, Midgley AR, Karsch FJ 1992 Dynamics of gonadotropin-releasing hormone release during a pulse. Endocrinology 130:503-510
4. Clarke IJ, Cummins JT 1982 The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111:1737-1739
5. Haisenleder DJ, Dalkin AC, Ortolano GA, Marshall JC, Shupnik MA 1991 A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology 128:509-517
6. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW 1997 Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology 138:1224-1231
7. Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E 1978 Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 202:631-633
8. Witkin JW, Silverman AJ 1985 Synaptology of luteinizing hormone-releasing hormone neurons in rat preoptic area. Peptides 6:263-271
9. Pompolo S, Rawson JA, Clarke IJ 2001 Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons. Brain Res 904:1-12
10. Pfleger KDG, Bogerd J, Millar RP 2002 Conformational constraint of mammalian, chicken, and salmon GnRHs, but not GnRH II, enhances binding at mammalian and nonmammalian receptors: evidence for preconfiguration of GnRH II. Mol Endocrinol 16:2155-2162
11. Jennes L, Dalati B, Conn PM 1988 Distribution of gonadotropin releasing hormone agonist binding sites in the rat central nervous system. Brain Res 452:156-164
12. Jennes L, Woolums S 1994 Localization of gonadotropin-releasing hormone receptor mRNA in rat brain. Endocrine 2:521-528
13. Jennes L, Eyigor O, Janovick JA, Conn PM 1997 Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Prog Horm Res 52:475-491
14. Valenca MM, Johnston CA, Ching M, Negro-Vilar A 1987 Evidence for a negative ultrashort loop feedback mechanism operating on the luteinizing hormone-releasing hormone neuronal system. Endocrinology 121:2256-2259
15. Bedran de Castro JC, Khorram O, McCann SM 1985 Possible negative ultrashort loop feedback of luteinizing hormone releasing hormone (LHRH) in the ovariectomized rat. Proc Soc Exp Biol Med 179:132-135
16. Padmanabhan V, Evans NP, Dahl GE, McFadden KL, Mauger DT, Karsch FJ 1995 Evidence for short or ultrashort loop negative feedback of gonadotropin- releasing hormone secretion. Neuroendocrinology 62:248-258
17. DePaolo LV, King RA, Carrillo AJ 1987 In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormone-releasing hormone. Endocrinology 120:272-279
18. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI 1990 Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10
19. Krsmanovic LZ, Stojilkovic SS, Mertz LM, Tomic M, Catt KJ 1993 Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc Natl Acad Sci USA 90:3908-3912
20. Krsmanovic LZ, Martinez-Fuentes AJ, Arora KK, Mores N, Navarro CE, Chen HC, Stojilkovic SS, Catt KJ 1999 Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology 140:1423-1431
21. Van Goor F, Krsmanovic LZ, Catt KJ, Stojilkovic SS 1999 Control of action potential-driven calcium influx in GT1 neurons by the activation status of sodium and calcium channels. Mol Endocrinol 13:587-603
22. Van Goor F, Krsmanovic LZ, Catt KJ, Stojilkovic SS 1999 Coordinate regulation of gonadotropin-releasing hormone neuronal firing patterns by cytosolic calcium and store depletion. Proc Natl Acad Sci USA 96:4101-4106
23. Suter KJ, Song WJ, Sampson TL, Wuarin JP, Saunders JT, Dudek FE, Moenter SM 2000 Genetic targeting of green fluorescent protein to gonadotropin- releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology. Endocrinology 141:412-419
24. Nunemaker CS, DeFazio RA, Moenter SM 2002 Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neurons. Endocrinology 143:2284-2292
25. Nunemaker CS, DeFazio RA, Moenter SM 2003 A-targeted extracellular approach for recording long-term firing patterns of excitable cells: a practical guide. Biol Proc Online 5:53-62
26. Pimstone B, Epstein S, Hamilton S, LeRoith D, Hendricks S 1977 Metabolic clearance and plasma half disappearance time of exogenous gonadotropin releasing hormone in normal subjects and in patients with liver disease and chronic renal failure. J Clin Endocrinol Metab 44:356-360
27. Lew RA, Cowley M, Clarke IJ, Smith AI 1997 Peptidases that degrade gonadotropin-releasing hormone: influence on LH secretion in the ewe. J Neuroendocrinol 9:707-712
28. Sidman RL, Angevine Jr JB, Taber-Pierce E 1971 Atlas of the mouse brain and spinal cord. Cambridge, MA: Harvard University Press
29. Haisenleder DJ, Burger LL, Aylor KW, Dalkin AC, Marshall JC 2003 Gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription: evidence for the involvement of calcium/calmodulin-dependent kinase II (Ca/CAMK II) activation in rat pituitaries. Endocrinology 144:2768-2774
30. Dutton A, Dyball RE 1979 Phasic firing enhances vasopressin release from the rat neurohypophysis. J Physiol 290:433-440
31. Nunemaker CS, DeFazio RA, Geusz ME, Herzog ED, Pitts GR, Moenter SM 2001 Long-term recordings of networks of immortalized GnRH neurons reveal episodic patterns of electrical activity. J Neurophysiol 86:86-93
32. Krsmanovic LZ, Mores N, Navarro CE, Arora KK, Catt KJ 2003 An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion. Proc Natl Acad Sci USA 100:2969-2974
33. Wiegand SJ, Terasawa E, Bridson WE, Goy RW 1980 Effects of discrete lesions of preoptic and suprachiasmatic structures in the female rat. Alterations in the feedback regulation of gonadotropin secretion. Neuroendocrinology 31:147-157
34. Hiatt ES, Brunetta PG, Seiler GR, Barney SA, Selles WD, Wooledge KH, King JC 1992 Subgroups of luteinizing hormone-releasing hormone perikarya defined by computer analyses in the basal forebrain of intact female rats. Endocrinology 130:1030-1043
35. Molter-Gerard C, Caraty A, Guerin S, Fontaine J, Taragnat C 2000 Dynamic changes in the gonadotrope cell subpopulations during an estradiol-induced surge in the ewe. Biol Reprod 63:1084-1091
36. Sim JA, Skynner MJ, Herbison AE 2001 Heterogeneity in the basic membrane properties of postnatal gonadotropin-releasing hormone neurons in the mouse. J Neurosci 21:1067-1075
37. Jennes L, Stumpf WE, Sheedy ME 1985 Ultrastructural characterization of gonadotropin-releasing hormone (GnRH)-producing neurons. J Comp Neurol 232:534-547
38. Ahnert-Hilger G, John M, Kistner U, Wiedenmann B, Jarry H 1998 Immortalized gonadotropin-releasing hormone neurons secrete γ- aminobutyric acid-evidence for an autocrine regulation. Eur J Neurosci 10:1145-1152
39. Spergel DJ, Kruth U, Hanley DF, Sprengel R, Seeburg PH 1999 GABA-and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice. J Neurosci 19:2037-2050
40. Lagrange AH, Ronnekleiv OK, Kelly MJ 1995 Estradiol-17 β and μ-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback? Endocrinology 136:2341-2344
41. Sim JA, Skynner MJ, Pape JR, Herbison AE 2000 Late postnatal reorganization of GABA(A) receptor signalling in native GnRH neurons. Eur J Neurosci 12:3497-3504
42. DeFazio RA, Heger S, Ojeda SR, Moenter SM 2002 Activation of A-type γ-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons. Mol Endocrinol 16:2872-2891
43. Finn PD, Clifton DK, Steiner RA 1998 The regulation of galanin gene expression in gonadotropin-releasing hormone neurons. Mol Cell Endocrinol 140:137-142
44. Mitchell V, Bouret S, Prevot V, Jennes L, Beauvillain JC 1999 Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area. J Neuroendocrinol 11:805-812
45. Kuehl-Kovarik MC, Pouliot WA, Halterman GL, Handa RJ, Dudek FE, Partin KM 2002 Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein. J Neurosci 22:2313-2322