The Promoter of the Rat Gonadotropin-Releasing Hormone Receptor Gene Directs the Expression of the Human Placental Alkaline Phosphatase Reporter Gene in Gonadotrope Cells in the Anterior Pituitary Gland as well as in Multiple Extrapituitary Tissues

Endocrinology

Volumn 145, Issue 2, 2004, Pages 983-993

  Granger, Anne ^a   Ngô Muller, Valérie ^b   Bleux, Christian ^a   Guigon, Céline ^a   Pincas, Hanna ^a   Magre, Solange ^a   Daegelen, Dominique ^b   Tixier Vidal, Andrée ^a   Counis, Raymond ^a   Laverrière, Jean Noël ^a  

^a CNRS   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; FOLLITROPIN BETA SUBUNIT; GONADORELIN RECEPTOR; GROWTH HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; THYROTROPIN BETA SUBUNIT;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL LINEAGE; CELL SPECIFICITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GONADOTROPIN SECRETING CELL; HIPPOCAMPUS; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR GENE; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; TRANSGENE; TRANSGENIC MOUSE;

ALKALINE PHOSPHATASE; ANIMALS; BRAIN CHEMISTRY; FEMALE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; GONADOTROPIN-RELEASING HORMONE; HISTOCYTOCHEMISTRY; HUMANS; LUTEINIZING HORMONE, BETA SUBUNIT; MALE; MICE; MICE, TRANSGENIC; PITUITARY GLAND, ANTERIOR; PLACENTA; PREGNANCY; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 10744233163     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0881     Document Type: Article

References (48)

1. Vazquez-Martinez R, Shorte SL, Boockfor FR, Frawley LS 2001 Synchronized exocytotic bursts from gonadotropin-releasing hormone-expressing cells: dual control by intrinsic cellular pulsatility and gap junctional communication. Endocrinology 142:2095-2101
2. Albarracin CT, Kaiser UB, Chin WW 1994 Isolation and characterization of the 5́-flanking region of the mouse gonadotropin-releasing hormone receptor gene. Endocrinology 135:2300-2306
3. Fan NC, Peng C, Krisinger J, Leung PCK 1995 The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals. Mol Cell Endocrinol 107:R1-R8
4. Campion CE, Turzillo AM, Clay CM 1996 The gene encoding the ovine gonadotropin-releasing hormone (GnRH) receptor: cloning and initial characterization. Gene 170:277-280
5. Reinhart J, Xiao S, Arora KK, Catt KJ 1997 Structural organization and characterization of the promoter region of the rat gonadotropin-releasing hormone receptor gene. Mol Cell Endocrinol 130:1-12
6. Kakar SS 1997 Molecular structure of the human gonadotropin-releasing hormone receptor gene. Eur J Endocrinol 137:183-192
7. Pincas H, Forraï Z, Chauvin S, Laverrière JN, Counis R 1998 Multiple elements in the distal part of the 1.2 kb 5′-flanking region of the rat GnRH receptor gene regulate gonadotrope-specific expression conferred by proximal domain. Mol Cell Endocrinol 144:95-108
8. Jiang Z, Gibson JP, Archibald AL, Haley CS 2001 The porcine gonadotropin-releasing hormone receptor gene (GNRHR): genomic organization, polymorphisms, and association with the number of corpora lutea. Genome 44:7-12
9. Duval DL, Nelson SE, Clay CM 1997 A binding site for steroidogenic factor-1 is part of a complex enhancer that mediates expression of the murine gonadotropin-releasing hormone receptor gene. Biol Reprod 56:160-168
10. Duval DL, Nelson SE, Clay CM 1997 The tripartite basal enhancer of the gonadotropin-releasing hormone (GnRH) receptor gene promoter regulates cell-specific expression through a novel GnRH receptor activating sequence. Mol Endocrinol 11:1814-1821
11. Ngan ES, Cheng PK, Leung PC, Chow BK 1999 Steroidogenic factor-1 interacts with a gonadotrope-specific element within the first exon of the human gonadotropin-releasing hormone receptor gene to mediate gonadotrope-specific expression. Endocrinology 140:2452-2462
12. Pincas H, Amoyel K, Counis R, Laverrière JN 2001 Proximal cis-acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene. Mol Endocrinol 15:319-337
13. Norwitz ER, Xu S, Jeong KH, Bedecarrats GY, Winebrenner LD, Chin WW, Kaiser UB 2002 Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology 143:985-997
14. Norwitz ER, Xu S, Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB 2002 Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)-and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem 277:37469-37478
15. McCue JM, Quirk CC, Nelson SE, Bowen RA, Clay CM 1997 Expression of a murine gonadotropin-releasing hormone receptor luciferase fusion gene in transgenic mice is diminished by immunoneutralization of gonadotropin-releasing hormone. Endocrinology 138:3154-3160
16. Duval DL, Farris AR, Quirk CC, Nett TM, Hamernik DL, Clay CM 2000 Responsiveness of the ovine gonadotropin-releasing hormone receptor gene to estradiol and gonadotropin-releasing hormone is not detectable in vitro but is revealed in transgenic mice. Endocrinology 141:1001-1010
17. Kisseberth WC, Brettingen NT, Lohse JK, Sandgren EP 1999 Ubiquitous expression of marker transgenes in mice and rats. Dev Biol 214:128-138
18. Salminen M, Lopez S, Maire P, Kahn A, Daegelen D 1996 Fast-muscle-specific DNA-protein interactions occurring in vivo at the human aldolase A promoter are necessary for correct promoter activity in transgenic mice. Mol Cell Biol 16:76-85
19. Dacheux F, Dubois MP 1976 Ultrastructural localization of prolactin, growth hormone and luteinizing hormone by immunocytochemical techniques in the bovine pituitary. Cell Tissue Res 174:245-260
20. Morohashi K, Zanger UM, Honda S, Hara M, Waterman MR, Omura T 1993 Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell specific transcription factor, Ad4BP. Mol Endocrinol 7:1196-1204
21. Jennes L 1990 Prenatal development of gonadotropin-releasing hormone receptors in the rat anterior pituitary. Endocrinology 126:942-947
22. Aubert ML, Begeot M, Winiger BP, Morel G, Sizonenko PC, Dubois PM 1985 Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats. Endocrinology 116: 1565-1576
23. Pickett CA, Gutierrez-Hartmann A 1997 Molecular and cellular ontogeny of distinct pituitary cell types. In: Wierman ME, ed. Contemporary endocrinology. Totowa, NJ: Humana Press Inc.; 1-31
24. Stoeckel ME, Hindelang C, Klein MJ, Poissonier M, Félix JM 1993 Early expression of the glycoprotein hormone α-subunit in the pars tuberalis of the rat pituitary gland during ontogenesis. Neuroendocrinology 58:616-624
25. Barnhart KM, Mellon PL 1994 The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes. Mol Endocrinol 8:878-885
26. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG 1999 Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell 97:587-598
27. Jennes L, Eyigor O, Janovick JA, Conn PM 1997 Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Prog Horm Res 52: 475-490
28. Leung PCK, Steele GL 1992 Intracellular signaling in the gonads. Endocr Rev 13:476-498
29. Jennes L, Woolums S 1994 Localization of gonadotropin-releasing hormone receptor mRNA in rat brain. Endocrine 2:521-528
30. Leblanc P, Crumeyrolle M, Latouche J, Jordan D, Fillion G, L'Heritier A, Kordon C, Dussaillant M, Rostene W, Haour F 1988 Characterization and distribution of receptors for gonadotropin-releasing hormone in the rat hippocampus. Neuroendocrinology 48:482-488
31. Jennes L, Dalati B, Conn PM 1988 Distribution of gonadotropin-releasing hormone agonist binding sites in the rat central nervous system. Brain Res 452:156-164
32. Alonso A, Kohler C 1982 Evidence for separate projections of hippocampal pyramidal and non-pyramidal neurons to different parts of the septum in the rat brain. Neurosci Lett. 31:209-214
33. Dasen JS, Rosenfeld MG 2001 Signaling and transcriptional mechanisms in pituitary development. Annu Rev Neurosci 24:327-355
34. Roselli CE, Jorgensen EZ, Doyle MW, Ronnekleiv OK 1997 Expression of the orphan receptor steroidogenic factor-1 mRNA in the rat medial basal hypothalamus. Brain Res Mol Brain Res 44:66-72
35. Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL 1995 The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 9:478-486
36. Parker KL 1998 The roles of steroidogenic factor-1 in endocrine development and function. Mol Cell Endocrinol 145:15-20
37. Wehrenberg U, Prange-Kiel J, Rune GM 2001 Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase. J Neurochem 76:1879-1886
38. Zhao Y, Sheng HZ, Amini R, Grinberg A, Lee E, Huang S, Taira M, Westphal H 1999 Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Science 284:1155-1158
39. Paylor R, Zhao Y, Libbey M, Westphal H, Crawley JN 2001 Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization. Physiol Behav 73:781-792
40. Pincas H, Laverrière JN, Counis R 2001 Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3′, 5′-monophosphate stimulate the promoter activity of the rat GnRH receptor gene via a bipartite response element in gonadotrope-derived cells. J Biol Chem 276:23562-23571
41. Zhao L, Bakke M, Krimkevich Y, Cushman LJ, Parlow AF, Camper SA, Parker KL 2001 Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 128:147-154
42. Moss RL, McCann SM 1973 Induction of mating behavior in rats by luteinizing hormone-releasing factor. Science 181:177-179
43. Moss RL, Foreman MM 1976 Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone. Neuroendocrinology 20:176-181
44. Ban E, Arias MC, Latouche J, Leblanc P, Heurtier JF, Drieu K, Fillion G, Haour F 1990 GnRH receptors in rat brain, pituitary and testis; modulation following surgical and gonadotropin-releasing hormone agonist-induced castration. Mol Cell Endocrinol 70:99-107
45. Jennes L, Brame B, Centers A, Janovick JA, Conn PM 1995 Regulation of hippocampal gonadotropin-releasing hormone (GnRH) receptor mRNA and GnRH-stimulated inositol phosphate production by gonadal steroid hormones. Mol Brain Res 33:104-110
46. Kanit L, Taskiran D, Yilmaz OA, Balkan B, Demirgoren S, Furedy JJ, Pogun S 2000 Sexually dimorphic cognitive style in rats emerges after puberty. Brain Res Bull 52:243-248
47. Shors TJ, Chua C, Falduto J 2001 Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. J Neurosci 21:6292-6297
48. Skinner DC, Caraty A 2002 Measurement and possible function of GnRH in cerebrospinal fluid in ewes. Reprod Suppl 59:25-39