Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1874-1881

  Al Tel, Taleb H ^a   Al Qawasmeh, Raed A ^b   Zaarour, Rania ^a  

^a UNIVERSITY OF SHARJAH   (United Arab Emirates)

^b UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Antibacterial; Antifungal; Benzimidazole; Imidazo 2,1 b 1,3 benzothiazole; Imidazopyridine; Oxadiazole; Phenyl imidazole

Indexed keywords

2 (5 BROMO 1H INDOL 3 YL) 7 FLUORO N (4 FLUOROPHENYL) IMIDAZO [2,1 B][1,3] BENZOTHIAZOL 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6 (5 PTOLYL 1,3,4 OXADIAZOL 2 YL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 FLUOROPHENYL) 1H IMIDAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 NITROPHENYL) 1,3,4 OXADIAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 NITROPHENYL) 1H IMIDAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (5 BROMO 1H INDOL 3 YL) N (4 FLUOROPHENYL) 6(5 4 TOLYL 1H IMIDAZOL 2 YL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) 6 (6 FLUORO 1H BENZO [D] IMIDAZOL 2 YL) N (4 FLUOROPHENYL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) 7 FLUORO N (4 FLUOROPHENYL) IMIDAZO [2,1 B][1,3] BENZOTHIAZOL 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 (5 4 TOLYL 1,3,4 OXADIAZOL 2 YL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 (5 4 TOLYL 1H IMIDAZOL 2 YL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 (6 METHYL 1H BENZO [D] IMIDAZOL 2 YL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 FLUOROPHENYL) 1H IMIDAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 [5 (4 NITROPHENYL) 1,3,4 OXADIAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 2 (6 BROMOQUINOLIN 3 YL) N (4 FLUOROPHENYL) 6 [6 NITRO 1H BENZO (D) IMIDAZOL 2 YL] IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 6 (6 BROMO 1H BENZO [D] IMIDAZOL 2 YL) 2 (5 FLUORO 1H INDOL 3 YL) N (4 FLUOROPHENYL) IMIDAZO [1,2 A] PYRIDIN 3 AMINE; 7 FLUORO N (4 FLUOROPHENYL) 2 (6 FLUOROQUINOLIN 3 YL) IMIDAZO [2,1 B][1,3] BENZOTHIAZOL 3 AMINE; 7 FLUORO N (4 FLUOROPHENYL) 2 (6 METHOXYQUINOLIN 3 YL) IMIDAZO [2,1 B][1,3] BENZOTHIAZOL 3 AMINE; 7 FLUORO N (4 FLUOROPHENYL) 2 (6 METHYLQUINOLIN 3 YL) IMIDAZO [2,1 B][1,3] BENZOTHIAZOL 3 AMINE; AMOXICILLIN; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BENZOTHIAZOLE DERIVATIVE; CEFIXIME; FLUCONAZOLE; IMIDAZO [1,2 A] PYRIDINE; IMIDAZO [2,1 B] [1,3] BENZOTHIAZOLE; IMIDAZOPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FUNGAL STRAIN; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; BENZOTHIAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FUNGI; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953171465     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.051     Document Type: Article

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