Indexed keywords
2 (1H INDOL 2 YL) 6 METHOXY 4A (PYRIDIN 4 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (1H INDOL 2 YL) 6 METHOXY 4A METHYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (1H INDOL 2 YL) 6 METHOXY 4A PHENYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (3,5 DICHLOROPHENYL) 6 METHOXY 4A (PYRIDIN 4 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (3,5 DICHLOROPHENYL) 6 METHOXY 4A METHYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (3,5 DIMETHOXYPHENYL) 6 METHOXY 4A (PYRIDIN 4 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (3,5 DIMETHOXYPHENYL) 6 METHOXY 4A METHYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (3,5 DIMETHOXYPHENYL) 6 METHOXY 4A PHENYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
2 (4 CHLOROPHENYL) 6 METHOXY 4A METHYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 2 (4 METHOXYPHENYL) 4A PHENYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 4A (PYRIDIN 4 YL) 2 P TOLYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 4A METHYL 2 (PYRIDIN 3 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 4A METHYL 2 (PYRIMIDIN 5 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 4A METHYL 2 4 TOLYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZON 3 (2H) ONE;
6 METHOXY 4A PHENYL 2 (PYRIMIDIN 5 YL) 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H) ONE;
6 METHOXY 4A PHENYL 2 4 TOLYL 4,4A,6,7 TETRAHYDRO 1H PYRANO[3,2 C]PYRIDAZIN 3(2H)ONE;
ANTINEOPLASTIC AGENT;
METHYL 2 (6 HYDROXY 2 METHYL 3 OXO 3,6 DIHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 2 METHOXY 3 OXO 2 PHENYL 3,6 DIHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 2 METHYL 3 OXO 3,6 DIHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 2 METHYL 3 OXOTETRAHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 3 OXO 2 (PYRIDIN 4 YL) 3,6 DIHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 3 OXO 2 PHENYL 3,6 DIHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 2 6 METHOXY 3 OXO 2 PHENYLTETRAHYDRO 2H PYRAN 2 YL ACETATE;
METHYL 3 (FURAN 2 YL) 3 HYDROXY 3 (PYRIDIN 4 YL)PROPANOATE;
METHYL 3 (FURAN 2 YL) 3 HYDROXY 3 PHENYLPROPANOATE;
METHYL 3 (FURAN 2 YL) 3 HYDROXYBUTANOATE;
UNCLASSIFIED DRUG;
ARTICLE;
BREAST CANCER;
CANCER CELL CULTURE;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG DETERMINATION;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
STRUCTURE ACTIVITY RELATION;
ANTINEOPLASTIC AGENTS;
CELL PROLIFERATION;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG DESIGN;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
MOLECULAR CONFORMATION;
PYRANS;
PYRAZOLES;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
TUMOR CELLS, CULTURED;
2
33644861259
D.G. Lloyd, G. Golfis, A.J. Knox, D. Fayne, M.J. Meegan, and T.I. Oprea Drug Discov. Today 11 2006 149 159
(2006)
Drug Discov. Today
, vol.11
, pp. 149-159
Lloyd, D.G.1
Golfis, G.2
Knox, A.J.3
Fayne, D.4
Meegan, M.J.5
Oprea, T.I.6
4
52449114832
J.L. Hickey, R.A. Ruhayel, P.J. Barnard, M.V. Baker, S.J. Berners-Price, and A. Filipovska J. Am. Chem. Soc. 130 2008 12570 12571
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 12570-12571
Hickey, J.L.1
Ruhayel, R.A.2
Barnard, P.J.3
Baker, M.V.4
Berners-Price, S.J.5
Filipovska, A.6
5
46849088554
B. Pedram, A. van Oeveren, D.E. Mais, K.B. Marschke, P.M. Verbost, M.B. Groen, and L. Zhi J. Med. Chem. 51 2008 3696 3699
(2008)
J. Med. Chem.
, vol.51
, pp. 3696-3699
Pedram, B.1
Van Oeveren, A.2
Mais, D.E.3
Marschke, K.B.4
Verbost, P.M.5
Groen, M.B.6
Zhi, L.7
6
28444498830
M.A. Koch, A. Schuffenhauer, M. Scheck, S. Wetzel, M. Casaulta, A. Odermatt, P. Ertl, and H. Waldmann Proc. Natl. Acad. Sci. U.S.A. 102 2005 17272 17277
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 17272-17277
Koch, M.A.1
Schuffenhauer, A.2
Scheck, M.3
Wetzel, S.4
Casaulta, M.5
Odermatt, A.6
Ertl, P.7
Waldmann, H.8
13
2942566175
P. Vuorelaa, M. Leinonenb, P. Saikkuc, P. Tammelaa, J.P. Rauhad, T. Wennberge, and H. Vuorela Curr. Med. Chem. 11 2004 1375 1389
(2004)
Curr. Med. Chem.
, vol.11
, pp. 1375-1389
Vuorelaa, P.1
Leinonenb, M.2
Saikkuc, P.3
Tammelaa, P.4
Rauhad, J.P.5
Wennberge, T.6
Vuorela, H.7
16
43049113156
I.V. Magedov, M. Manpadi, M.A. Ogasawara, A.S. Dhawan, S. Rogelj, S. Van Slambrouck, W.F.A. Steelant, N.M. Evdokimov, P.Y. Uglinskii, E.M. Elias, E.J. Knee, P. Tongwa, and M.Y. Antipin J. Med. Chem. 51 2008 2561 2570
(2008)
J. Med. Chem.
, vol.51
, pp. 2561-2570
Magedov, I.V.1
Manpadi, M.2
Ogasawara, M.A.3
Dhawan, A.S.4
Rogelj, S.5
Van Slambrouck, S.6
Steelant, W.F.A.7
Evdokimov, N.M.8
Uglinskii, P.Y.9
Elias, E.M.10
Knee, E.J.11
Tongwa, P.12
Antipin, M.Y.13
17
41149121692
B. Raghavan, R. Balasubramanian, J.C. Steele, D.L. Sackett, and R.A. Fecik J. Med. Chem. 51 2008 1530 1533
(2008)
J. Med. Chem.
, vol.51
, pp. 1530-1533
Raghavan, B.1
Balasubramanian, R.2
Steele, J.C.3
Sackett, D.L.4
Fecik, R.A.5
23
0001462758
O.J. Achmatowicz, P. Bukowski, B. Szechner, Z. Zwierzchowska, and A. Zamojski Tetrahedron 27 1971 1973 1996
(1971)
Tetrahedron
, vol.27
, pp. 1973-1996
Achmatowicz, O.J.1
Bukowski, P.2
Szechner, B.3
Zwierzchowska, Z.4
Zamojski, A.5
26
70350048595
T.H. Al-Tel, R.A. Al-Qawasmeh, M.F. Schmidt, A. Al-Aboudi, S.N. Rao, S.S. Sabri, and W. Voelter J. Med. Chem. 52 2009 6484 6488
(2009)
J. Med. Chem.
, vol.52
, pp. 6484-6488
Al-Tel, T.H.1
Al-Qawasmeh, R.A.2
Schmidt, M.F.3
Al-Aboudi, A.4
Rao, S.N.5
Sabri, S.S.6
Voelter, W.7
28
40749093598
N. Micale, S. Colleoni, G. Postorino, A. Pellicano, M. Zappala, J. Lazzaro, V. Diana, A. Cagnotto, T. Mennini, and S. Grasso Bioorg. Med. Chem. 16 2008 2200 2211
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 2200-2211
Micale, N.1
Colleoni, S.2
Postorino, G.3
Pellicano, A.4
Zappala, M.5
Lazzaro, J.6
Diana, V.7
Cagnotto, A.8
Mennini, T.9
Grasso, S.10
29
2942538366
C.V.C. Prasad, S. Vig, D.W. Smith, Q. Gao, C.T. Polson, J.A. Corsa, V.L. Guss, A. Loo, D.M. Barten, M. Zheng, K.M. Felsenstein, and S.B. Roberts Bioorg. Med. Chem. Lett. 14 2004 3535 3538
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3535-3538
Prasad, C.V.C.1
Vig, S.2
Smith, D.W.3
Gao, Q.4
Polson, C.T.5
Corsa, J.A.6
Guss, V.L.7
Loo, A.8
Barten, D.M.9
Zheng, M.10
Felsenstein, K.M.11
Roberts, S.B.12
30
0037740001
M. Van der Mey, K.M. Bommele, H. Boss, A. Hatzelmann, M. Van Slingerland, G.J. Sterk, and G.H. Timmerman J. Med. Chem. 46 2003 2008 2016
(2003)
J. Med. Chem.
, vol.46
, pp. 2008-2016
Van Der Mey, M.1
Bommele, K.M.2
Boss, H.3
Hatzelmann, A.4
Van Slingerland, M.5
Sterk, G.J.6
Timmerman, G.H.7
31
0035952284
S. Grasso, G. De Sarro, A. De Sarro, N. Micale, S. Polimeni, M. Zappala, G. Puia, M. Baraldi, and C. De Micheli Bioorg. Med. Chem. Lett. 11 2001 463 466
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 463-466
Grasso, S.1
De Sarro, G.2
De Sarro, A.3
Micale, N.4
Polimeni, S.5
Zappala, M.6
Puia, G.7
Baraldi, M.8
De Micheli, C.9
32
0026663316
J. Bolos, A. Perez, S. Gubert, L. Anglada, A. Sacristan, and J.A. Ortiz J. Org. Chem. 57 1992 3535 3539
(1992)
J. Org. Chem.
, vol.57
, pp. 3535-3539
Bolos, J.1
Perez, A.2
Gubert, S.3
Anglada, L.4
Sacristan, A.5
Ortiz, J.A.6
33
0025108835
A. Mertens, W.G. Friebe, B.M. Beckmann, W. Kampe, L. Kling, and W. Von der Saal J. Med. Chem. 33 1990 2870 2875
(1990)
J. Med. Chem.
, vol.33
, pp. 2870-2875
Mertens, A.1
Friebe, W.G.2
Beckmann, B.M.3
Kampe, W.4
Kling, L.5
Von Der Saal, W.6
34
0035913051
D. Barlocco, G. Cignarella, V.D. Piaz, M.P. Giovannoni, P.G.D. Benedetti, F. Fanelli, F. Montesano, E. Poggesi, and A. Leonardi J. Med. Chem. 44 2001 2403 2410
(2001)
J. Med. Chem.
, vol.44
, pp. 2403-2410
Barlocco, D.1
Cignarella, G.2
Piaz, V.D.3
Giovannoni, M.P.4
Benedetti, P.G.D.5
Fanelli, F.6
Montesano, F.7
Poggesi, E.8
Leonardi, A.9
35
0035935132
F. Bevacqua, A. Basso, R. Gitto, M. Bradley, and A. Chimirri Tetrahedron Lett. 42 2001 7683 7685
(2001)
Tetrahedron Lett.
, vol.42
, pp. 7683-7685
Bevacqua, F.1
Basso, A.2
Gitto, R.3
Bradley, M.4
Chimirri, A.5
36
0027940432
P.G. Baraldi, A. Bigoni, B. Cacciare, C. Caldari, S. Manfredini, and G. Spalluto Synthesis 11 1994 1158 1162
(1994)
Synthesis
, vol.11
, pp. 1158-1162
Baraldi, P.G.1
Bigoni, A.2
Cacciare, B.3
Caldari, C.4
Manfredini, S.5
Spalluto, G.6
38
17844393652
D.D. Xu, T. George, X. Jiang, K. Prasad, O. Repic, and T.J. Blacklock J. Heterocycl. Chem. 42 2005 131 135
(2005)
J. Heterocycl. Chem.
, vol.42
, pp. 131-135
Xu, D.D.1
George, T.2
Jiang, X.3
Prasad, K.4
Repic, O.5
Blacklock, T.J.6
39
0017098501
A.A. Asselin, L.G. Humber, T.A. Dobson, J. KomLossy, and R.R. Martel J. Med. Chem. 19 1976 787 792
(1976)
J. Med. Chem.
, vol.19
, pp. 787-792
Asselin, A.A.1
Humber, L.G.2
Dobson, T.A.3
Komlossy, J.4
Martel, R.R.5