Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: A new class of antimicrobial agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3330-3339

  Rohini, Rondla ^a   Shanker, Kanne ^a   Reddy, Puchakayala Muralidhar ^a,b   Ho, Yen Peng ^b   Ravinder, Vadde ^a  

^a KAKATIYA UNIVERSITY   (India)

^b NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Antibacterial activity; Antifungal activity; Mono, bis 6 arylbenzimidazo 1,2 c quinazolines; Synthesis

Indexed keywords

6 (2 PYRIDYL)BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLINE; 6 (2 THIENYL)BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLINE; 6 (5 BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLIN 6 YL 2 THIENYL)BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLINE; 6 (6 BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLIN 6 YL 2 PYRIDYL)BENZO[4,5]IMIDAZO[1,2 C]QUINAZOLINE; AMPICILLIN; BENZIMIDAZO[1,2 C]QUINAZOLINE DERIVATIVE; KETOCONAZOLE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; TRICHODERMA;

ANTI-INFECTIVE AGENTS; BACTERIA; DRUG DESIGN; FUNGI; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; QUINAZOLINES; SPECTRUM ANALYSIS;

EID: 67349113171     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.022     Document Type: Article

References (33)

1. Zhang Y., Chen Z., Lou Y., and Yu Y. Eur. J. Med. Chem. 44 (2009) 448-452
2. Kumar A., and Rajput C.S. Eur. J. Med. Chem. 44 (2009) 83-90
3. Arienzo R., Cramp S., Dyke H.J., Lockey P.M., Norman D., Roach A.G., Smith P., Wong M., and Wren S.P. Bioorg. Med. Chem. Lett. 17 (2007) 1403-1407
4. Kung P., Casper M.D., Cook K.L., Lingardo L.W., Risen L.M., Vickers T.A., Ranken R., Blyn L.B., Wyatt J.R., Dan Cook P., and Ecker D.J. J. Med. Chem. 42 (1999) 4705-4713
5. Genady A.R. Eur. J. Med. Chem. 44 (2009) 409-416
6. Alagarsamy V., Rupeshkumar M., Kavitha K., Meena S., Shankar D., Siddiqui A.A., and Rajesh R. Eur. J. Med. Chem. 43 (2008) 2331-2337
7. Chandrika P.M., Yakaiah T., Rao A.R., Narsaiah B., Reddy N.C., Sridhar V., and Rao J.V. Eur. J. Med. Chem. 43 (2008) 846-852
8. Grasso S., Micale N., Monforte A.M., Monforte P., Polimeni S., and Zappal M. Eur. J. Med. Chem. 35 (2000) 1115-1119
9. Herget T., Freitag M., Morbitzer M., Kupfer R., Stamminger T., and Marschall M. Antimicrob. Agents Chemother. 48 (2004) 4154-4162
10. Chapoulaud V.G., Ple N., Turck A., and Queguiner G. Tetrahedron 56 (2000) 5499-5507
11. Daly C.J., Milligan C.M., Milligan G., Mackenzie J.F., and Mcgrath J.C. J. Pharmacol. Exp. Ther. 286 (1998) 984-990
12. Chan K.P., Yang H., and Hay A.S. J. Polym. Sci. 34 (1996) 1923-1931
13. Galarcei G.D., Foncea R.E., Edwards A.M., Pessoamahana H., Mahana C.D.P., and Ebenspergeri R.A. Biol. Res. 41 (2008) 43-50
14. Via L.D., Gia O., Mango S.M., Settimo A.D., Marini A.M., Primofiore G., Settimo F.D.A., and Salerno S. Farmaco 56 (2001) 159-167
15. Lamazzi C., Leonce S., Pfeiffer B., Renard P., Guillaumet G., Rees C.W., and Besson T. Bioorg. Med. Chem. 10 (2000) 2183-2185
16. Lunn W.H.W., Harper R.W., and Stone R.L. J. Med. Chem. 14 (1971) 1069-1071
17. Brana M.F., Castellano J.M., Keilhauer G., Machuca A., Martin Y., Redondo C., Schlick E., and Walker N. Anticancer. Drug Des. 9 (1994) 527-538
18. Spasov A.A., Yozhitsa I.N., Bugaeva L.I., and Anisimova V.A. Pharma. Chem. J. 33 (1999) 232-243
19. Fernández B., Castellano J., and Redondo M. Eur. Pat. Appl. 331 (1989) 093
20. Insuasty B.A., Torres H., Quiroga J., Abonia R., Rodriguez R., Nogueras M., Sanchez A., Saitz C., Alvarez S.L., and Zacchino S.A. J. Chil. Chem. Soc. 51 (2006) 927-932
21. Vostrova L.N., Voronina T.A., Karaseva T.L., Gernega S.A., Ivanov E.I., Kirichenko A.M., Yu M., and Totrova. Pharma. Chem. J. 20 (1986) 404-406
22. Hein D.W., Alheim R.J., and Leavitt J.J. J. Am. Chem. Soc. 79 (1957) 427-429
23. Davis M., and Mann F.G. J. Chem. Soc. (1962) 945-954
24. Pareek S., Vyas S., Seth G., and Vyas P.C. Heteroat. Chem. 19 (2008) 154-157
25. Fadda A.A., Refat H.M., Zaki M.E.A., and Monir E. Synth. Commun. 31 (2001) 3537-3545
26. Amudha P., Akilan P., and Kandaswamy M. Polyhedron 18 (1999) 1355-1362
27. Korshak V.V., Rusanov A.L., Iremashvili T.G., Plieva L.K., and Lekae T.V. Die Makromolekulare Chemie 176 (1973) 1271
28. Jung H.J., Singh N., and Jang D.O. Tetrahedron Lett. 49 (2008) 2960-2964
29. P.M. Reddy, Y.P. Ho, K. Shanker, R. Rohini, V. Ravinder, Eur. J. Med. Chem., in press.
30. Alam S. J. Chem. Sci. 166 (2004) 325-332
31. Omrum U., Arikan S., Kocago S., Semeak B., and Unala S. Diagn. Microbiol. Infect. Dis. 38 (2000) 101-107
32. Malue M., Bastide J.M., and Biancard A. Int. J. Antimicrob. Agents 25 (2005) 321-328
33. Cruickshank R., Duguid J.P., Marmion B.P., and Swain R.H.A. Medical Microbiology. 12th ed. vol. II (1975)