Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2280-2285

  Coban, Gunes ^a   Zencir, Sevil ^b   Zupkó, István ^c   Réthy, Borbála ^c   Gunes, H Semih ^a   Topcu, Zeki ^a  

^a EGE UNIVERSITY   (Turkey)

^b PAMUKKALE UNIVERSITY   (Turkey)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

1H Benzimidazole derivatives; MTT assay; Plasmid Supercoil relaxation assays; Synthesis; Type I DNA topoisomerase

Indexed keywords

2 (1H BENZIMIDAZOL 2 YL) PHENOL; 2 (5 CHLORO 1H BENZIMIDAZOL 2 YL)PHENOL; 2 [2 (2 MORPHOLIN 4 YLETHOXY)PHENYL] 1H BENZIMIDAZOLE; 2 [2 (2 PIPERIDIN 1 YLETHOXY)PHENYL] 1H BENZIMIDAZOLE; 2 [2 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 1H BENZIMIDAZOLE; 2 [2 (5 CHLORO 1H BENZIMIDAZOL 2 YL)PHENOXY] N,N DIETHYLETHANAMINE; 5 CHLORO 2 (2 HYDROXYPHENYL) 1H BENZIMIDAZOLE; 5 CHLORO 2 [2 (2 MORPHOLIN 4 YLETHOXY)PHENYL] 1H BENZIMIDAZOLE; 5 CHLORO 2 [2 (2 PIPERIDIN 1 YLETHOXY) PHENYL] 1H BENZIMIDAZOLE; 5 CHLORO 2 [2 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 1H BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; DNA TOPOISOMERASE; DOXORUBICIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CYTOSTATIC AGENTS; DNA TOPOISOMERASES, TYPE I; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62549162118     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.018     Document Type: Article

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