Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 7, 2005, Pages 1943-1947

  Hamdouchi, Chafiq ^a   Zhong, Boyu ^a   Mendoza, Jose ^a   Collins, Elizabeth ^a   Jaramillo, Carlos ^b   De Diego, Jose Eugenio ^b   Robertson, Daniel ^a   Spencer, Charles D ^a   Anderson, Bryan D ^a   Watkins, Scott A ^a   Zhang, Faming ^a   Brooks, Harold B ^a  

^a ELI LILLY AND COMPANY   (United States)

^b ELI LILLY AND COMPANY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMIDAZOPYRIDINE DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C GAMMA;

AMINO ACID SEQUENCE; ARTICLE; CELL PROLIFERATION; CELL STRAIN HCT116; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 20144366009     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.01.052     Document Type: Article

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