메뉴 건너뛰기




Volumn 10, Issue 6, 2011, Pages 364-367

γδ T cells and multiple sclerosis: Friends, foes, or both?

Author keywords

T cells; Cytotoxicity; Immunoregulation; Multiple sclerosis; NK receptors

Indexed keywords

CD16 ANTIGEN; INTERLEUKIN 17; MYELIN; NATURAL KILLER CELL RECEPTOR NKG2D;

EID: 79953162539     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2010.12.005     Document Type: Review
Times cited : (4)

References (41)
  • 1
    • 0032722822 scopus 로고    scopus 로고
    • Multiple sclerosis and central nervous system demyelination
    • Pouly S., Antel J.P. Multiple sclerosis and central nervous system demyelination. J Autoimmun. 1999, 13:297-306.
    • (1999) J Autoimmun. , vol.13 , pp. 297-306
    • Pouly, S.1    Antel, J.P.2
  • 2
    • 77649237783 scopus 로고    scopus 로고
    • Multiple sclerosis: geoepidemiology, genetics and the environment
    • Milo R., Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev. 2010, 9:A387-A394.
    • (2010) Autoimmun Rev. , vol.9
    • Milo, R.1    Kahana, E.2
  • 4
    • 67349275439 scopus 로고    scopus 로고
    • The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    • Smolders J., Peelen E., Thewissen M., Menheere P., Tervaert J.W., Hupperts R., et al. The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev. 2009, 8:621-626.
    • (2009) Autoimmun Rev. , vol.8 , pp. 621-626
    • Smolders, J.1    Peelen, E.2    Thewissen, M.3    Menheere, P.4    Tervaert, J.W.5    Hupperts, R.6
  • 6
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp B.D., Nave K.A. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci. 2008, 31:247-269.
    • (2008) Annu Rev Neurosci. , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 8
    • 77956172807 scopus 로고    scopus 로고
    • Determining gammadelta versus alphabeta T cell development
    • Ciofani M., Zuniga-Pflucker J.C. Determining gammadelta versus alphabeta T cell development. Nat Rev Immunol. 2010, 10:657-663.
    • (2010) Nat Rev Immunol. , vol.10 , pp. 657-663
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 9
    • 0034091286 scopus 로고    scopus 로고
    • Gammadelta cells: a right time and a right place for a conserved third way of protection
    • Hayday A.C. gammadelta cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol. 2000, 18:975-1026.
    • (2000) Annu Rev Immunol. , vol.18 , pp. 975-1026
    • Hayday, A.C.1
  • 10
    • 0034653471 scopus 로고    scopus 로고
    • Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression
    • Yin Z., Zhang D.H., Welte T., Bahtiyar G., Jung S., Liu L., et al. Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J Immunol. 2000, 164:3056-3064.
    • (2000) J Immunol. , vol.164 , pp. 3056-3064
    • Yin, Z.1    Zhang, D.H.2    Welte, T.3    Bahtiyar, G.4    Jung, S.5    Liu, L.6
  • 11
    • 0032105478 scopus 로고    scopus 로고
    • Mechanism of gammadelta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis
    • Zeine R., Pon R., Ladiwala U., Antel J.P., Filion L.G., Freedman M.S. Mechanism of gammadelta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis. J Neuroimmunol. 1998, 87:49-61.
    • (1998) J Neuroimmunol. , vol.87 , pp. 49-61
    • Zeine, R.1    Pon, R.2    Ladiwala, U.3    Antel, J.P.4    Filion, L.G.5    Freedman, M.S.6
  • 12
    • 0043076185 scopus 로고    scopus 로고
    • Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites
    • Dieli F., Poccia F., Lipp M., Sireci G., Caccamo N., Di Sano C., et al. Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites. J Exp Med. 2003, 198:391-397.
    • (2003) J Exp Med. , vol.198 , pp. 391-397
    • Dieli, F.1    Poccia, F.2    Lipp, M.3    Sireci, G.4    Caccamo, N.5    Di Sano, C.6
  • 14
    • 0026079842 scopus 로고
    • Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis
    • Selmaj K., Brosnan C.F., Raine C.S. Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci U S A. 1991, 88:6452-6456.
    • (1991) Proc Natl Acad Sci U S A. , vol.88 , pp. 6452-6456
    • Selmaj, K.1    Brosnan, C.F.2    Raine, C.S.3
  • 16
    • 0030994648 scopus 로고    scopus 로고
    • Gamma delta T-cell-human glial cell interactions. I. In vitro induction of gammadelta T-cell expansion by human glial cells
    • Freedman M.S., D'Souza S., Antel J.P. gamma delta T-cell-human glial cell interactions. I. In vitro induction of gammadelta T-cell expansion by human glial cells. J Neuroimmunol. 1997, 74:135-142.
    • (1997) J Neuroimmunol. , vol.74 , pp. 135-142
    • Freedman, M.S.1    D'Souza, S.2    Antel, J.P.3
  • 18
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R.M., Kivisakk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol. 2003, 3:569-581.
    • (2003) Nat Rev Immunol. , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 19
    • 0033120075 scopus 로고    scopus 로고
    • IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+T lymphocytes from healthy donors and multiple sclerosis patients
    • Poggi A., Zocchi M.R., Costa P., Ferrero E., Borsellino G., Placido R., et al. IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+T lymphocytes from healthy donors and multiple sclerosis patients. J Immunol. 1999, 162:4349-4354.
    • (1999) J Immunol. , vol.162 , pp. 4349-4354
    • Poggi, A.1    Zocchi, M.R.2    Costa, P.3    Ferrero, E.4    Borsellino, G.5    Placido, R.6
  • 20
    • 38149111863 scopus 로고    scopus 로고
    • Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis
    • Smith S.S., Barnum S.R. Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis. J Leukoc Biol. 2008, 83:71-79.
    • (2008) J Leukoc Biol. , vol.83 , pp. 71-79
    • Smith, S.S.1    Barnum, S.R.2
  • 21
    • 0036082564 scopus 로고    scopus 로고
    • Gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression
    • Murzenok P.P., Matusevicius D., Freedman M.S. gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression. Clin Immunol. 2002, 103:309-316.
    • (2002) Clin Immunol. , vol.103 , pp. 309-316
    • Murzenok, P.P.1    Matusevicius, D.2    Freedman, M.S.3
  • 22
    • 33846829507 scopus 로고    scopus 로고
    • NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis
    • Saikali P., Antel J.P., Newcombe J., Chen Z., Freedman M., Blain M., et al. NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. J Neurosci. 2007, 27:1220-1228.
    • (2007) J Neurosci. , vol.27 , pp. 1220-1228
    • Saikali, P.1    Antel, J.P.2    Newcombe, J.3    Chen, Z.4    Freedman, M.5    Blain, M.6
  • 23
    • 4444342402 scopus 로고    scopus 로고
    • FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways
    • Angelini D.F., Borsellino G., Poupot M., Diamantini A., Poupot R., Bernardi G., et al. FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways. Blood. 2004, 104:1801-1807.
    • (2004) Blood. , vol.104 , pp. 1801-1807
    • Angelini, D.F.1    Borsellino, G.2    Poupot, M.3    Diamantini, A.4    Poupot, R.5    Bernardi, G.6
  • 24
    • 39849104447 scopus 로고    scopus 로고
    • Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis
    • Chen Z., Freedman M.S. Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis. J Neuroimmunol. 2008, 194:147-152.
    • (2008) J Neuroimmunol. , vol.194 , pp. 147-152
    • Chen, Z.1    Freedman, M.S.2
  • 25
    • 46749115940 scopus 로고    scopus 로고
    • CD16+ gammadelta T cells mediate antibody dependent cellular cytotoxicity: potential mechanism in the pathogenesis of multiple sclerosis
    • Chen Z., Freedman M.S. CD16+ gammadelta T cells mediate antibody dependent cellular cytotoxicity: potential mechanism in the pathogenesis of multiple sclerosis. Clin Immunol. 2008, 128:219-227.
    • (2008) Clin Immunol. , vol.128 , pp. 219-227
    • Chen, Z.1    Freedman, M.S.2
  • 26
    • 73649108262 scopus 로고    scopus 로고
    • The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis
    • Kaushansky N., Eisenstein M., Zilkha-Falb R., Ben-Nun A. The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis. Autoimmun Rev. 2010, 9:233-236.
    • (2010) Autoimmun Rev. , vol.9 , pp. 233-236
    • Kaushansky, N.1    Eisenstein, M.2    Zilkha-Falb, R.3    Ben-Nun, A.4
  • 28
    • 33846327273 scopus 로고    scopus 로고
    • Absence of perforin expression confers axonal protection despite demyelination
    • Howe C.L., Adelson J.D., Rodriguez M. Absence of perforin expression confers axonal protection despite demyelination. Neurobiol Dis. 2007, 25:354-359.
    • (2007) Neurobiol Dis. , vol.25 , pp. 354-359
    • Howe, C.L.1    Adelson, J.D.2    Rodriguez, M.3
  • 29
    • 1042299971 scopus 로고    scopus 로고
    • Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions
    • Hoftberger R., Aboul-Enein F., Brueck W., Lucchinetti C., Rodriguez M., Schmidbauer M., et al. Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions. Brain Pathol. 2004, 14:43-50.
    • (2004) Brain Pathol. , vol.14 , pp. 43-50
    • Hoftberger, R.1    Aboul-Enein, F.2    Brueck, W.3    Lucchinetti, C.4    Rodriguez, M.5    Schmidbauer, M.6
  • 30
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease
    • Bjartmar C., Wujek J.R., Trapp B.D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci. 2003, 206:165-171.
    • (2003) J Neurol Sci. , vol.206 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 32
    • 67349196003 scopus 로고    scopus 로고
    • Multiplexing approaches for autoantibody profiling in multiple sclerosis
    • Somers K., Govarts C., Stinissen P., Somers V. Multiplexing approaches for autoantibody profiling in multiple sclerosis. Autoimmun Rev. 2009, 8:573-579.
    • (2009) Autoimmun Rev. , vol.8 , pp. 573-579
    • Somers, K.1    Govarts, C.2    Stinissen, P.3    Somers, V.4
  • 33
    • 2942718822 scopus 로고    scopus 로고
    • Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production
    • Odyniec A., Szczepanik M., Mycko M.P., Stasiolek M., Raine C.S., Selmaj K.W. Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production. J Immunol. 2004, 173:682-694.
    • (2004) J Immunol. , vol.173 , pp. 682-694
    • Odyniec, A.1    Szczepanik, M.2    Mycko, M.P.3    Stasiolek, M.4    Raine, C.S.5    Selmaj, K.W.6
  • 34
    • 0032736525 scopus 로고    scopus 로고
    • Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene
    • Spahn T.W., Issazadah S., Salvin A.J., Weiner H.L. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. Eur J Immunol. 1999, 29:4060-4071.
    • (1999) Eur J Immunol. , vol.29 , pp. 4060-4071
    • Spahn, T.W.1    Issazadah, S.2    Salvin, A.J.3    Weiner, H.L.4
  • 35
    • 17044374687 scopus 로고    scopus 로고
    • Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism
    • Ponomarev E.D., Dittel B.N. Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J Immunol. 2005, 174:4678-4687.
    • (2005) J Immunol. , vol.174 , pp. 4678-4687
    • Ponomarev, E.D.1    Dittel, B.N.2
  • 36
    • 0034839754 scopus 로고    scopus 로고
    • Modulation of the severity of experimental autoimmune encephalomyelitis by gammadelta T lymphocytes activated by mycobacterial antigens
    • Diaz-Bardales B.M., Novaski S.M., Goes A.E., Castro G.M., Mengel J., Santos L.M. Modulation of the severity of experimental autoimmune encephalomyelitis by gammadelta T lymphocytes activated by mycobacterial antigens. Immunol Invest. 2001, 30:245-258.
    • (2001) Immunol Invest. , vol.30 , pp. 245-258
    • Diaz-Bardales, B.M.1    Novaski, S.M.2    Goes, A.E.3    Castro, G.M.4    Mengel, J.5    Santos, L.M.6
  • 37
    • 0033084235 scopus 로고    scopus 로고
    • Cytokine secretion by deltagamma and alphabeta T cells in monophasic experimental autoimmune encephalomyelitis
    • Jensen M.A., Dayal A., Arnason B.G. Cytokine secretion by deltagamma and alphabeta T cells in monophasic experimental autoimmune encephalomyelitis. J Autoimmun. 1999, 12:73-80.
    • (1999) J Autoimmun. , vol.12 , pp. 73-80
    • Jensen, M.A.1    Dayal, A.2    Arnason, B.G.3
  • 39
    • 77957021670 scopus 로고    scopus 로고
    • Gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
    • Petermann F., Rothhammer V., Claussen M.C., Haas J.D., Blanco L.R., Heink S., et al. gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity. 2010, 33:351-363.
    • (2010) Immunity. , vol.33 , pp. 351-363
    • Petermann, F.1    Rothhammer, V.2    Claussen, M.C.3    Haas, J.D.4    Blanco, L.R.5    Heink, S.6
  • 40
    • 0032105479 scopus 로고    scopus 로고
    • Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination
    • Stinissen P., Zhang J., Vandevyver C., Hermans G., Raus J. Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination. J Neuroimmunol. 1998, 87:94-104.
    • (1998) J Neuroimmunol. , vol.87 , pp. 94-104
    • Stinissen, P.1    Zhang, J.2    Vandevyver, C.3    Hermans, G.4    Raus, J.5
  • 41
    • 0034744297 scopus 로고    scopus 로고
    • Interferon beta1a treatment modulates TH1 expression in gammadelta+T cells from relapsing-remitting multiple sclerosis patients
    • Elliott C.L., El-Touny S.Y., Filipi M.L., Healey K.M., Leuschen M.P. Interferon beta1a treatment modulates TH1 expression in gammadelta+T cells from relapsing-remitting multiple sclerosis patients. J Clin Immunol. 2001, 21:200-209.
    • (2001) J Clin Immunol. , vol.21 , pp. 200-209
    • Elliott, C.L.1    El-Touny, S.Y.2    Filipi, M.L.3    Healey, K.M.4    Leuschen, M.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.