The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis

Autoimmunity Reviews

Volumn 9, Issue 4, 2010, Pages 233-236

  Kaushansky, Nathali ^a   Eisenstein, Miriam ^a   Zilkha Falb, Rina ^a   Ben Nun, Avraham ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

HLA DR15 Tg mice; MOBP; MS EAE; Neuroimmunology; T cells

Indexed keywords

AUTOANTIGEN; HLA DQ ANTIGEN; HLA DR15 ANTIGEN; MEMBRANE PROTEIN; MYELIN ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

AUTOIMMUNITY; DEMYELINATION; DISEASE ASSOCIATION; DISEASE COURSE; GENETIC SUSCEPTIBILITY; IMMUNE RESPONSE; MOUSE STRAIN; MULTIPLE SCLEROSIS; NONHUMAN; OPTIC NEURITIS; PATHOGENESIS; PROTEIN DETERMINATION; PROTEIN TARGETING; REVIEW; T LYMPHOCYTE;

ANIMALS; AUTOANTIGENS; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; HLA-DR ANTIGENS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; MYELIN PROTEOLIPID PROTEIN; MYELIN-ASSOCIATED GLYCOPROTEIN; OPTIC NEURITIS; T-LYMPHOCYTES;

EID: 73649108262     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2009.08.002     Document Type: Review

References (40)

1. Hohlfeld R., and Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci U S A 101 Suppl 2 (2004) 14599-14606
2. Sospedra M., and Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 23 (2005) 683-747
3. Ben-Nun A., Wekerle H., and Cohen I.R. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 292 (1981) 60-61
4. Hafler D.A. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. J Clin Invest 104 (1999) 527-529
5. de Rosbo N.K., and Ben-Nun A. T-cell responses to myelin antigens in multiple sclerosis; relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J Autoimmun 11 (1998) 287-299
6. N. Kerlero de Rosbo, A. Ben-Nun, Experimental Autoimmune Encephalomyelitis Induced by Various Antigens of the Central Nervous System: Overview and Relevance to Multiple Sclerosis. In The decade of autoimmunity 1987-1997. Y. Shoenfeld, editor. Amsterdam: Elsevier Science.vol. 199: 169-177.
7. Holz A., Bielekova B., Martin R., and Oldstone M.B. Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. J Immunol 164 (2000) 1103-1109
8. Kaye J.F., Kerlero de Rosbo N., Mendel I., Flechter S., Hoffman M., Yust I., et al. The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS). J Neuroimmunol 102 (2000) 189-198
9. Grau-Lopez L., Raich D., Ramo-Tello C., Naranjo-Gomez M., Davalos A., Pujol-Borrell R., et al. Myelin peptides in multiple sclerosis. Autoimmun Rev 8 (2009) 650-653
10. Morris-Downes M.M., McCormack K., Baker D., Sivaprasad D., Natkunarajah J., and Amor S. Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice. J Neuroimmunol 122 (2002) 20-33
11. Fontoura P., Ho P.P., DeVoss J., Zheng B., Lee B.J., Kidd B.A., et al. Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol 173 (2004) 6981-6992
12. Karnezis T., Mandemakers W., McQualter J.L., Zheng B., Ho P.P., Jordan K.A., et al. The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci 7 (2004) 736-744
13. Mor F., Quintana F., Mimran A., and Cohen I.R. Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein. J Immunol 170 (2003) 628-634
14. Kela-Madar N., de Rosbo N.K., Ronen A., Mor F., and Ben-Nun A. Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, beta-synuclein. J Neuroimmunol 208 (2009) 19-29
15. Huizinga R., Gerritsen W., Heijmans N., and Amor S. Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments. Neurobiol Dis 32 (2008) 461-470
16. Huizinga R., Heijmans N., Schubert P., Gschmeissner S., t Hart B.A., Herrmann H., et al. Immunization with neurofilament light protein induces spastic paresis and axonal degeneration in Biozzi ABH mice. J Neuropathol Exp Neurol 66 (2007) 295-304
17. Krishnamoorthy G., Saxena A., Mars L.T., Domingues H.S., Mentele R., Ben-Nun A., et al. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med 15 (2009) 626-632
18. Hafler D.A., Slavik J.M., Anderson D.E., O'Connor K.C., De Jager P., and Baecher-Allan C. Multiple sclerosis. Immunol Rev 204 (2005) 208-231
19. Hellings N., Raus J., and Stinissen P. T-cell vaccination in multiple sclerosis: update on clinical application and mode of action. Autoimmun Rev 3 (2004) 267-275
20. Montague P., McCallion A.S., Davies R.W., and Griffiths I.R. Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function. Dev Neurosci 28 (2006) 479-487
21. Yamamoto Y., Mizuno R., Nishimura T., Ogawa Y., Yoshikawa H., Fujimura H., et al. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. J Biol Chem 269 (1994) 31725-31730
22. Holz A., and Schwab M.E. Developmental expression of the myelin gene MOBP in the rat nervous system. J Neurocytol 26 (1997) 467-477
23. Yamamoto Y., Yoshikawa H., Nagano S., Kondoh G., Sadahiro S., Gotow T., et al. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Eur J Neurosci 11 (1999) 847-855
24. Holz A., Schaeren-Wiemers N., Schaefer C., Pott U., Colello R.J., and Schwab M.E. Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci 16 (1996) 467-477
25. McCallion A.S., Stewart G.J., Montague P., Griffiths I.R., and Davies R.W. Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein. Mol Cell Neurosci 13 (1999) 229-236
26. Sadahiro S., Yoshikawa H., Yagi N., Yamamoto Y., Yanagihara T., Kimura M., et al. Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Neuroscience 98 (2000) 361-367
27. Maatta J.A., Kaldman M.S., Sakoda S., Salmi A.A., and Hinkkanen A.E. Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase for BALB/c and SJL mice. Immunology 95 (1998) 383-388
28. de Rosbo N.K., Kaye J.F., Eisenstein M., Mendel I., Hoeftberger R., Lassmann H., et al. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. J Immunol 173 (2004) 1426-1435
29. Kaushansky N., Zilkha-Falb R., Hemo R., Lassman H., Eisenstein M., Sas A., et al. Pathogenic T cells in MOBP-induced murine EAE are predominantly focused to recognition of MOBP21F and MOBP27P epitopic residues. Eur J Immunol 37 (2007) 3281-3292
30. Reich D., Patterson N., De Jager P.L., McDonald G.J., Waliszewska A., Tandon A., et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet 37 (2005) 1113-1118
31. Finn T.P., Jones R.E., Rich C., Dahan R., Link J., David C.S., et al. HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes. J Neurosci Res 78 (2004) 100-114
32. Caillier S.J., Briggs F., Cree B.A., Baranzini S.E., Fernandez-Vina M., Ramsay P.P., et al. Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol 181 (2008) 5473-5480
33. Sawcer S., Maranian M., Setakis E., Curwen V., Akesson E., Hensiek A., et al. A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility. Brain 125 (2002) 1337-1347
34. Altmann D.M., Douek D.C., Frater A.J., Hetherington C.M., Inoko H., and Elliott J.I. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J Exp Med 181 (1995) 867-875
35. Mangalam A.K., Khare M., Krco C., Rodriguez M., and David C. Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice. Eur J Immunol 34 (2004) 280-290
36. Khare M., Rodriguez M., and David C.S. HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis. Int Immunol 15 (2003) 535-546
37. Kaushansky N., Altmann D.M., Takacs K., Ellmerich S., David C.S., Lassman H., and Ben-Nun A. HLA-DQB1*0602 Determines Disease Susceptibility in a New 'Humanized' Multiple Sclerosis Model in HLA-DR15 (DRB1*1501;DQB1*0602) Transgenic Mice. J Immunol 183 (2009) 3531-3541
38. Kerlero de Rosbo N., Milo R., Lees M.B., Burger D., Bernard C.C., and Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 92 (1993) 2602-2608
39. Zhong M.C., Cohen L., Meshorer A., Kerlero de Rosbo N., and Ben-Nun A. T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice. J Neuroimmunol 105 (2000) 39-45
40. Stevens D.B., Chen K., Seitz R.S., Sercarz E.E., and Bronstein J.M. Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol 162 (1999) 7501-7509