Biological effects of space radiation on human cells:History, advances and outcomes

Journal of Radiation Research

Volumn 52, Issue 2, 2011, Pages 126-146

  Maalouf, Mira ^a,b   Durante, Marco ^c   Foray, Nicolas ^a  

^a GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^b CNES   (France)

^c GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEAVY IONS; RADIATION EFFECTS; RADIATION HAZARDS; RISK ASSESSMENT; RISK PERCEPTION; SPACE RESEARCH;

BASIC MECHANISM; BIOLOGICAL EFFECTS; BIOLOGICAL RESPONSE; HUMAN CELLS; LOW DOSE; RADIATION BIOLOGY; SPACE EXPLORATIONS; SPACE RADIATION EXPOSURE; SPACE RADIATIONS; TECHNOLOGICAL DEVELOPMENT;

CELL CULTURE;

EID: 79953145338     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.10128     Document Type: Review

References (131)

1. White RJ and Averner M (2001) Humans in space. Nature 409: 1115-1118.
2. Cucinotta FA and Durante M (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol 7: 431-435.
3. Durante M and Cucinotta FA (2008) Heavy ion carcinogenesis and human space exploration. Nature Review Cancer 8: 465-472.
4. Durante M (2002) Biological effects of cosmic radiation in low-Earth orbit. Int J Modern Phys A A17: 1713-1721.
5. NCRP (2006) Information needed to make radiation protection recommendations for space missions beyond low-earth orbit. Report N.153. National Commission for Radiation Protection; Bethesda, MD, USA.
6. Parker EN (2006) Shielding space travelers. Scientific American 294: 40-47.
7. NASA (2009) Human health and performance risks for space exploration missions. NASA-SP-2009-3405.; Houston, TX, USA.
8. ESA (2003) HUMEX: Study in survivability and adaptation of humans to long-duration interplanetary and planetary environments. ESA-ESTEC/SP-1264. European Space Agency.
9. NAS (2006) Space Studies Board. Space radiation hazards and the vision for space explorations. National Academy of Sciences of USA. National Academy Press.
10. Held KD (2009) Effects of low fluences of radiations found in space on cellular systems. Int J Radiat Biol 85: 379-390.
11. Lear J (1965) Kepler's dream. Univ. of California Press; Berkeley, USA.
12. Todd P, et al (1974) Current topics in space radiation biology. In: Tobias C, Todd P eds. Space radiation biology and related topics. pp. 1-18. Academic Press; New York and London.
13. Millikan RA (1947) Electrons (+ and -), protons, photons, neutrons, mesotrons and cosmic rays. University of Chicago Press; Chicago, Illinois, USA.
14. Hess VF and Eugster JAG (1949) Cosmic radiation and its biological effects. Fordham Univ. Press; New York.
15. Johnson TH (1939) Evidence that protons are the primary particles of the hard component. Review Modelling Physics 11: 208-210.
16. Haffner JW (1967) Radiation and shielding in space. In. pp. Academic Press; City.
17. Freier P, et al (1948) Evidence of heavy nuclei in the primary cosmic radiation. Physics Reviews 74: 213-217.
18. Van Allen JA and Franck LA (1959) Radiation around the earth to a radial distance of 107,400 km. Nature 183: 430.
19. Van Allen JA and Franck LA (1959) Radiation measurements to 658,300 km with Pioneer IV. Nature 184: 219.
20. Singer SF (1958) Trapped albedo theory of the radiation belt. Physics Reviw Letter 1: 181.
21. Neugebauer M and Snyder CW (1964) Interplanetary solar wind measurements by Mariner II. In: Muller P eds. Space Research. pp. 89-113. North-Holland Publications; Amsterdam.
22. Winckler JR, et al (1961) The time variation of solar cosmic rays during July 1959 at Minneapolis. J Geophys Res 66: 995-1022.
23. Joubert A and Foray N (2006) Repair of radiation-induced DNA double-strand breaks in human cells: history, progress and controversies. In: Landseer Br eds. New Research on DNA Repair. pp. Chapter 10. Nova Science Publishers, Inc.; Hauppauge N. Y.
24. Comstock GM, et al (1969) Energy spectra and abundances of the cosmic-ray nuclei helium to iron from the OGO-1 satellite experiment. Astrophysics Journal 155: 609-617.
25. Benton ER and Benton EV (2001) Space radiation dosimetry in low-Earth orbit and beyond. Nucl Instrum Methods Phys Res B 184: 255-294.
26. Bethe HA and Ashkin J (1953) Passage of radiations through matter. In: Segre E eds. Experimental Nuclear Physics. pp. Wiley; New York.
27. Bertini HW (1963) Low-energy intranuclear cascade calculation. Physics Review Letter 131: 1801-1821.
28. Jorgensen AM, et al (2007) Passive radiation shielding considerations for the proposed space elevator. Acta Astronautica 60: 198-209.
29. Durante M (2008) Physical and biomedical countermeasures for space radiation risk. Z Med Phys 18: 244-252.
30. Pugliese M, et al (2010) Tests of shielding effectiveness of Kevlar and Nextel onboard the International Space Station and the Foton-M3 capsule. Radiat Environ Biophys 49: 359-363.
31. Spillantini P, et al (2007) Shielding from cosmic radiation for interplanetary missions: active and passive methods. Radiation Measurements 42: 14-23.
32. Curtis SB (1974) Physics and dosimetry. In: Tobias Ca, Todd P eds. Space radiation biology and related topics. pp. 21-99. Academic Press; New York.
33. Schneider M and Janni JF (1969) A comprehensive summary of dose rate measurements abpard the fourth and sixth Gemini flights in The current experimental approach to the radiological problem of space flight (J.F. Janni and F.E. Holly, eds). Aerosp Med 40: 1535-1546.
34. Bailey JV, et al (1977) Radiological protection and medical dosimetry fro the Skylab. Chapter 9. In: Dietlein Rsjalf eds. Biomedical results from Skylab NASA SP 377. pp. NASA; Washington.
35. Fenech M (2000) The in vitro micronucleus technique. Mutat Res 455: 81-95.
36. Grote SJ, et al (1981) Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture, and its effect on colony-forming ability. Int J Radiat Biol Relat Stud Phys Chem Med 39: 395-408.
37. Bender MA, et al (1968) The Gemini XI S-4 spaceflight-radiation interaction experiment: the human blood experiment. Radiat Res 34: 228-238.
38. Bender MA, et al (1967) The Gemini-3 S-4 spaceflight-radiation interaction experiment. Radiat Res 31: 91-111.
39. Kovalev EE and Grigoriev YG (1970) Effects on the organism of radiation energy of cosmic space. In: Ussr Aoso eds. Bases of cosmic biology and medicine. pp.
40. Parin VV, et al (1969) Characteristics of biological effects of cosmic radiation, model investigations. In: Favorite Wvafg eds. Life Sciences and Space Research. pp. 160-170. North Holland; Amsterdam.
41. Kimzey SL, et al (1975) Hematology and Immunology Studies. In: Johnston Rs, Dietlein Lf, Berry Ca eds. Biomedical results of Apollo NASA SP368 Report Section III Volume III. pp. Bio Technology, Inc.; New York.
42. Johnston RS and Dietlein LF (1977) Biomedical results from Skylab. NASA SP377. NASA; Washington.
43. Budinger TF, et al (1977) Light flash observations. Experiment MA-106. Volume 1. Astronomy, Earth Atmosphere and Gravity Field, Life Sciences, and Materials Processing. In: Center Lbjs eds. Apollo-Soyuz Test Project Summary Science Report, NASA Special Publication NASA SP-412. pp. 193-209. NASA; Washington.
44. Lockhart LH (1977) Cytogenetic studies of blood (Experiment M111).Chapter 24. In: Johnston Rs, Dietlein Lf eds. Biomedical results from Skylab NASA SP 377. pp. NASA; Washington.
45. Kozlova SB, et al (1978) [Measurement of the radiation doses in the area of the inner radiation belt of the Earth]. Kosm Biol Aviakosm Med 12: 85-87.
46. Markelov VV and Chernykh IV (1982) [Radiation control on Saliut stations using directly indicating dosimeters]. Kosm Biol Aviakosm Med 16: 81-84.
47. Red'ko VI, et al (1974) [Dosimetric studies on the orbital cosmic station "Saliut"]. Kosm Biol Aviakosm Med 8: 3-6.
48. Gagarin Yu F, et al (1998) Heavy particle fluxes in Salyut space station orbit. Adv Space Res 21: 1699-1702.
49. Bogomolov AV, et al (1998) Energetic neutron and gamma-ray spectra under the earth radiation belts according to "SALYUT-7" [correction of "SALUTE-7"]-"KOSMOS-1686" orbital complex and "CORONAS-I" satellite data. Adv Space Res 21: 1801-1804.
50. O'Neill JP, et al (1987) Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans. Mutagenesis 2: 87-94.
51. Khaidakov M, et al (1999) Study on genotoxic effects of the space environment: a comparison between experienced cosmonauts and unexposed Russian twins. Mutat Res 430: 337-
52. Khaidakov M, et al (1997) Molecular analysis of mutations in T-lymphocytes from experienced Soviet cosmonauts. Environ Mol Mutagen 30: 21-30.
53. NCRP (1989) Guidance on radiation received in space activities. National Commission for Radiation Protection; Bethesda, MD, USA.
54. Testard I, et al (1996) Radiation-induced chromosome damage in astronauts' lymphocytes. Int J Radiat Biol 70: 403-411.
55. Obe G, et al (1997) Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int J Radiat Biol 72: 727-734.
56. Testard I and Sabatier L (1999) Biological dosimetry for astronauts: a real challenge. Mutat Res 430: 315-326.
57. Bidoli V, et al (2000) Study of cosmic rays and light flashes on board Space Station MIR: the SilEye experiment. Adv Space Res 25: 2075-2079.
58. Avdeev S, et al (2002) Eye light flashes on the Mir space station. Acta Astronaut 50: 511-525.
59. Casolino M, et al (2003) Study of the radiation environment on MIR space station with SILEYE-2 experiment. Adv Space Res 31: 135-140.
60. Ritter S and Durante M (2010) Heavy-ion induced chromosomal aberrations: A review. Mutat Res 174: 14-19.
61. Obe G and Durante M (2010) DNA double strand breaks and chromosomal aberrations. Cytogenet Genome Res 128: 8-16.
62. Rothkamm K and Lobrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A 100: 5057-5062.
63. Ohnishi T, et al (2009) Detection of space radiation-induced double strand breaks as a track in cell nucleus. Biochem Biophys Res Commun 390: 485-488.
64. Takahashi A, et al (2010) The first life science experiments in ISS: reports of "Rad Gene"- Space radiation effects on human cultured cells. Biol Sci Space 24: 17-41.
65. Takahashi A, et al (2010) The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight. Int J Radiat Biol 86: 669-681.
66. Fuglesang C, et al (2006) Phosphenes in low earth orbit: survey responses from 59 astronauts. Aviat Space Environ Med 77: 449-452.
67. Casolino M, et al (2003) Space travel: Dual origins of light flashes seen in space. Nature 422: 680.
68. Sannita WG, et al (2007) Electrophysiological responses of the mouse retina to 12C ions. Neurosci Lett 416: 231-235.
69. Sannita WG, et al (2004) Effects of heavy ions on visual function and electrophysiology of rodents: the ALTEA-MICE project. Adv Space Res 33: 1347-1351.
70. Narici L, et al (2004) The ALTEA/ALTEINO projects: studying functional effects of microgravity and cosmic radiation. Adv Space Res 33: 1352-1357.
71. Tubiana M, et al (2009) The linear no-threshold relationship is inconsistent with radiation biologic and experimental data. Radiology 251: 13-22.
72. Cucinotta FA, et al (2001) Space radiation and cataracts in astronauts. Radiat Res 156: 460-466.
73. Blakely EA and Chang PY (2007) A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: cataracts and CNS effects. Adv Space Res 40: 1307-1319.
74. Ainsbury EA, et al (2009) Radiation cataractogenesis: a review of recent studies. Radiat Res 172: 1-9.
75. Shore RE, et al (2010) Epidemiological studies of cataract risk at low to moderate radiation doses: (not) seeing is believing. Radiat Res 174: 889-894.
76. ICRP (1991) 1990 Recommendations of the International Commission on Radiological Protection. Publication ICRP N. 60. Annual ICRP Publications, Vol. 21. Pergamon Press; Oxford.
77. ICRP (2007) 2006 Recommendations 2006 of the International Commission on Radiological Protection. Publication ICRP N. 103. Annual ICRP Publications, Vol.37. Pergamon Press; Oxford.
78. Joubert A and Foray N (2007) [Intrinsic radiosensitivity and DNA double-strand breaks in human cells]. Cancer Radiother 11: 129-142.
79. Joubert A, et al (2008) DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity? Int J Radiat Biol 84: 1-19.
80. Joiner MC, et al (2001) Low-dose hypersensitivity: current status and possible mechanisms. Int J Radiat Oncol Biol Phys 49: 379-389.
81. Marples B, et al (2004) Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiat Res 161: 247-255.
82. Skov KA, et al (1999) Radioresponsiveness at low doses: hyper-radiosensitivity and increased radioresistance in mammalian cells. Mutat Res 430: 241-253.
83. Mitchell CR, et al (2002) Effects of exposure to low-dose-rate (60)co gamma rays on human tumor cells in vitro. Radiat Res 158: 311-318.
84. Mitchell CR and Joiner MC (2002) Effect of subsequent acute-dose irradiation on cell survival in vitro following low dose-rate exposures. Int J Radiat Biol 78: 981-990.
85. Vaganay-Juery S, et al (2000) Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation. Br J Cancer 83: 514-518.
86. Thomas C, et al (2008) Low-dose hyper-radiosensitivity of progressive and regressive cells isolated from a rat colon tumour: impact of DNA repair. Int J Radia Biol 84: 533-548.
87. Slonina D, et al (2007) Low-dose radiation response of primary keratinocytes and fibroblasts from patients with cervix cancer. Radiat Res 167: 251-259.
88. Foray N, et al (1997) Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: a closer look. Biochimie 79: 567-575.
89. Foray N, et al (1998) Repair of radiation-induced DNA double-strand breaks in human fibroblasts is consistent with a continuous spectrum of repair probability. Int J Radiat Biol 74: 551-560.
90. Foray N, et al (2005) The repair rate of radiation-induced DNA damage: a stochastic interpretation based on the gamma function. J Theor Biol 236: 448-458.
91. Chavaudra N, et al (2004) Quantified relationship between cellular radiosensitivity, DNA repair defects and chromatin relaxation: a study of 19 human tumour cell lines from different origin. Radiother Oncol 73: 373-382.
92. Ponette V, et al (1996) Pulse exposure to ionizing radiation elicits rapid changes in cellular radiosensitivity. C R Acad Sci III 319: 505-509.
93. Ponette V, et al (2000) Hyperfast, early cell response to ionizing radiation. Int J Radiat Biol 76: 1233-1243.
94. Feinendegen LE (2005) Evidence for beneficial low level radiation effects and radiation hormesis. Br J Radiol 78: 3-7.
95. Matsumoto H, et al (2009) A new paradigm in radioadaptive response developing from microbeam research. J Radiat Res (Tokyo) 50 Suppl A: A67-A79.
96. Elmore E, et al (2008) Low doses of very low-dose-rate low-LET radiation suppress radiation-induced neoplastic transformation in vitro and induce an adaptive response. Radiat Res 169: 311-318.
97. Carbone MC, et al (2009) The Cosmic Silence experiment: on the putative adaptive role of environmental ionizing radiation. Radiat Environ Biophys 48: 189-196.
98. Ina Y, et al (2005) Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat Res 163: 153-158.
99. Lacoste-Collin L, et al (2007) Effect of continuous irradiation with a very low dose of gamma rays on life span and the immune system in SJL mice prone to B-cell lymphoma. Radiat Res 168: 725-732.
100. Takahashi A, et al (2010) P53-dependent adaptive responses in human cells exposed to space radiation. Int J Radiat Oncol Biol Phys 78: 1171-1176.
101. Regaud C and Lacassagne A (1927) Effets histophysiologiques des rayons de Roentgen et de Becquerel-Curie sur les tissus adultes normaux des animaux supérieurs. In: Regaud C eds. Radiophysiologie et Radiothérapie. pp. Presses Universitaires de France; Paris, France.
102. Bouchacourt ML (1911) Sur la différence de sensibilité aux rayons de Roentgen de la peau des différents sujets, et, sur le même sujet des différents régions du corps. In: Sciences. Splad eds. pp. 942-947. Masson; Paris.
103. Fertil B and Malaise EP (1981) Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. Int J Radiat Oncol Biol Phys 7: 621-629.
104. Deschavanne PJ and Fertil B (1996) A review of human cell radiosensitivity in vitro. Int J Radiat Oncol Biol Phys 34: 251-266.
105. Joubert A and Foray N (2006) Repair of radiation-induced DNA double-strand breaks in human cells: History, Progress and Controversies. In: Landseer Br eds. In: New Research on DNA Repair. pp. Nova Science Publishers, Inc.
106. Swift M, et al (1991) Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325: 1831-1836.
107. Hall EJ and Giacca AJ (2006) Radiobiology for the radiologist. Lippincott Wilkins & Williams; Philadelphia, USA.
108. Cucinotta F, et al (2001) Space radiation cancer risks and uncertainties for Mars missions. Radiat Res 156: 682-688.
109. Cucinotta FA and Chappell LJ (2010) Non-targeted effects and the dose response for heavy ion tumor induction. Mutation Res 687: 49-53.
110. De Ruyck K, et al (2006) TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors. Int J Radiat Oncol Biol Phys 65: 1240-1248.
111. Willems P, et al (2008) Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity. Genes Chromosomes Cancer 47: 137-148.
112. Massart C, et al (2009) Prediction of the human radiosensitivity: what is the most relevant endpoint? Gene expressions, mutations or functions? In: Hauppauge Ny eds. Genotoxicity, Testing and Prediction. pp. Nova Science Publishers, Inc.; New York, USA.
113. Kushiro J, et al (1990) Absence of correlations between radiosensitivities of human T-lymphocytes in G0 and skin fibroblasts in log phase. Radiat Res 122: 326-332.
114. Green MH, et al (1991) Comparative human cellular radiosensitivity: III. Gamma-radiation survival of cultured skin fibroblasts and resting T-lymphocytes from the peripheral blood of the same individual. Int J Radiat Biol 59: 749-765.
115. Geara FB, et al (1992) Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation. Cancer Res 52: 6348-6352.
116. Gooch PC and Berry CA (1969) Chromosome analyses of Gemini astronauts. Aerosp Med 40: 610-614.
117. Yang TC, et al (1997) Biodosimetry results from space flight Mir-18. Radiat Res 148: S17-S23.
118. Druzhinin SV (1999) [Cytogenetic effect in lymphocytes in astronauts after 2 lengthy flights on board MIR orbital station]. Aviakosm Ekolog Med 33: 3-5.
119. Fedorenko B, et al (2001) Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station. Adv Space Res 27: 355-359.
120. Fedorenko BS, et al (2000) [Cytogenetic studies of blood lymphocytes of cosmonauts after long-ter, space flights]. Radiats Biol Radioecol 40: 596-602.
121. George K, et al (2001) Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat Res 156: 731-738.
122. Wu H, et al (2001) Comparison of chromosome aberration frequencies in pre- and post-flight astronaut lymphocytes irradiated in vitro with gamma rays. Phys Med 17 Suppl 1: 229-231.
123. George K, et al (2003) In vivo and in vitro measurements of complex-type chromosomal exchanges induced by heavy ions. Adv Space Res 31: 1525-1535.
124. George K, et al (2004) Chromosome aberrations of clonal origin are present in astronauts' blood lymphocytes. Cytogenet Genome Res 104: 245-251.
125. Greco O, et al (2003) Biological dosimetry in Russian and Italian astronauts. Adv Space Res 31: 1495-1503.
126. Durante M, et al (2003) Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet Genome Res 103: 40-46.
127. George K, et al (2005) Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting. Radiat Res 164: 474-480.
128. Horstmann M, et al (2005) Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts' lymphocytes. Radiat Environ Biophys 44: 219-224.
129. Pelevina II, et al (2007) [Individual cytogenetic and molecular-biological characteristics of lymphocytes in blood of pilots and cosmonauts]. Radiats Biol Radioecol 47: 141-150.
130. Fedorenko BS, et al (2008) [Cytogenetic effects on blood lymphocytes of cosmonauts after low doses of space radiation]. Aviakosm Ekolog Med 42: 13-18.
131. George K, et al (2010) Persistence of space radiation induced cytogenetic damage in the blood lymphocytes of astronauts. Mutat Res 2010 Aug 14; 701(1): 75-79.