In vivo and in vitro measurements of complex-type chromosomal exchanges induced by heavy ions

Advances in Space Research

Volumn 31, Issue 6, 2003, Pages 1525-1535

  George, K ^a,c   Durante, M ^b   Wu, H ^a,c   Willingham, V ^a,c   Cucinotta, F A ^c  

^a WYLE LABORATORIES   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; BLOOD; CHROMOSOMES; COMPLEXATION; IONIZING RADIATION; PHOSPHATES; STATISTICAL METHODS;

RADIATION FIELDS;

HEAVY IONS;

CHROMOSOME;

EID: 0038638209     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-1177(03)00088-7     Document Type: Article

References (28)

1. Anderson, R.M., S.J. Marsden, E.G. Wright, K.A. Kadhim, D.T. Goodhead, and C.S. Griffin, Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET α-particles, Int. J. Radiat. Biol., 76, 31-42, 2000.
2. Bauchinger, M. and E. Schmid, Commentary: Is there a reliable experimental evidence for a chromosomal "fingerprint" of exposure to densely ionizing radiation? Radiat. Res., 147, 506-510, 1997.
3. Brenner, D.J. and R.K. Sachs, Commentary: Chromosomal "fingerprints" of prior exposure to densely ionizing radiation. Radiat. Res., 140, 14-142, 1994.
4. Cornforth, M. Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res., 155, 643-659, 2001.
5. Durante, M., K. George, H. Wu, and F.A. Cucinotta, Karyotypes of Human Lymphocytes Exposed to High-Energy Iron Ions. Radiat. Res., 158, 581-590, 2002.
6. Durante, M., Y. Furusawa, H. Majima, T. Kawata, and E. Gotoh, Association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiat. Res., 151, 670-676, 1999.
7. Durante, M., Y. Furusawa, K. George, G. Gialanella, O. Greco, G. Grossi, N. Matsufuji, M. Pugliese, and T.C. Yang, Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiat. Res., 149, 446-454, 1998.
8. Durante, M., K. George, and T.C. Yang, Biodosimetry of ionizing radiation by selective painting of prematurely condensed chromosomes in human lymphocytes. Radiat. Res., 148, S45-S50, 1997.
9. Furusawa, Y, K. Fukutsu, M. Aoki, H. Itsukaichi, K. Eguchi-Kasai, H. Ohara, F. Yatagai, T. Kanai, and K. Ando, Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne-ion beams. Radiat. Res., 154, 485-496, 2000.
10. George, K., M. Durante, H. Wu, V. Willingham, G. Badhwar, and F.A. Cucinotta, Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res., 156, 731-738, 2001a.
11. George, K., H. Wu, V. Willingham, Y. Furusawa, T. Kawata, and F.A. Cucinotta, High-and low-LET induced chromosome damage in human lymphocytes: a time course of aberrations in metaphase and interphase. Int. J. Radiat. Biol., 77, 175-183, 2001b.
12. Kiefer, J., P. Schmidt, and S. Koch, Mutations in mammalian cells induced by heavy charged particles: an indicator for risk assessment in space. Radiat. Res., 156, 607-611, 2001.
13. Kovacs, M.S., J.W. Evans, I.M. Johnstone, and J.M. Brown, Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization. Radiat. Res., 137, 34-43, 1994.
14. Lucas, J.N., M. Poggensee, and T. Straume, The persistence of chromosome translocations in a radiation worker accidentally exposed to tritium. Cytogenet. Cell Genet., 60, 255-256, 1992.
15. Luomahaara, S, C. Lindholm, R. Mustonen, and S. Salomaa, Distribution of radiation-induced exchange aberrations in human chromosomes 1,2 and 4. Int. J. Radiat. Biol., 75, 1551-1556, 1999.
16. Moquet, J.E., J.L. Fernandez, A.A. Edwards, and D.C. Lloyd, Lymphocyte chromosomal aberrations and their complexity induced in vitro by plutonium-239 alpha-particles and detected by FISH. Cell Mol. Biol., 47, 549-556, 2001.
17. Obe, G., I. J., C. Johannes, K. Hallman, G. Reitz, and R. Facius, Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int. J. Radiat. Biol., 72, 727-734, 1997.
18. Ritter, S., E. Nasonova, E. Gudowska-Nowak, M. Scholz, and G. Kraft, High-LET-induced chromosome aberrations in V79 cells analysed in first and second post-irradiation metaphases. Int. J. Radiat. Biol., 76, 149-161, 2000.
19. Savage, J.R. and D.G. Papworth, Comment on the ratio of chromosome-type dicentric interchanges to centric rings for track-clustered compared with random breaks. Radiat. Res., 146, 236-240, 1996.
20. Savage, J.R.K. and P.J. Simpson, On scoring of FISH-"painted" chromosome-type exchange aberrations. Mutat. Res., 307, 345-343, 1994.
21. Scholz, M., S. Ritter and G. Kraft, Analysis of chromosome damage based on the time course of aberrations. Int. J. of Radiat. Biol., 74, 325-331, 1998.
22. Simpson, P.J., D.G. Papworth, and J.R. Savage, X-ray-induced simple, pseudosimple and complex exchanges involving two distinctly painted chromosomes. Int. J. Radiat., Biol., 75, 11-18, 1999.
23. Simpson, P.J. and J.R. Savage, Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization. Inter, J. of Radiat. Biol., 69, 429-436, 1996.
24. Testard I., B. Dutrillaux, and L. Sabatier. Chromosomal aberrations induced in human lymphocytes by high-LET irradiation. Int. J. of Radiat. Biol., 72, 423-433, 1997.
25. Tucker, J.D., and J.R. Senft, Analysis of naturally occurring and radiation induced breakpoint locations in human chromosomes 1,2 and 4. Radiat. Res., 140, 31-36, 1994.
26. Wu, H., M. Durante, K. George, and T.C. Yang, Induction of chromosome aberrations in human cells by charged particles. Radiat. Res., 148, S102-7, 1997.
27. Yang, T.C., K. G., A.S. Johnson, M. Durante, and B.S. Federenko, Biodosimetry results from space flight Mir-18. Radiat. Res., 148, 17-23, 1997.
28. Yang, T.C., L.M. Craise, M.T. Mei, and C.A. Tobias, Neoplastic cell transformation by heavy charged particles. Radiat. Res., 8, S177-187, 1985.