Persistence of space radiation induced cytogenetic damage in the blood lymphocytes of astronauts

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 701, Issue 1, 2010, Pages 75-79

  George, K ^a   Chappell, L J ^b   Cucinotta, F A ^c  

^a WYLE LABORATORIES   (United States)

^b USRA   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

Author keywords

Biodosimetry; Chromosomal aberrations; Space radiation

Indexed keywords

ARTICLE; CHROMATID EXCHANGE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DAMAGE; CHROMOSOME PAINTING; CONTROLLED STUDY; COSMIC RADIATION; COSMONAUT; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LYMPHOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; SPACE FLIGHT; RADIATION RESPONSE; TIME; ULTRASTRUCTURE;

ASTRONAUTS; CHROMOSOME ABERRATIONS; COSMIC RADIATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; SPACE FLIGHT; TIME FACTORS;

EID: 77955095153     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.02.007     Document Type: Article

References (21)

1. Cucinotta F.A., Wilson J.W., Williams J.R., Dicello J.F. Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO. Radiat. Meas. 2000, 32:181-191.
2. George K., Durante M., Wu H., Willingham V., Badhwar G., Cucinotta F.A. Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res. 2001, 156:731-738.
3. Greco O., Durante M., Gialanella G., Grossi G., Pugliese M., Scampoli P., Snigiryova G., Obe G. Biological dosimetry in Russian and Italian astronauts. Adv. Space Res. 2003, 13(6):1495-1503.
4. Obe G., Johannes I., Johannes C., Hallman K., Reitz G., Facius R. Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int. J. Radiat. Biol. 1997, 72:727-734.
5. Cucinotta F.A., Kim M.Y., Willingham V., George K.A. Physical and biological organ dosimetry analysis for international space station astronauts. Radiat. Res. 2008, 170:127-138.
6. George K., Willingham V., Cucinotta F.A. Stability of chromosome aberrations in the blood lymphocytes of astronauts after space flight by FISH chromosome painting. Radiat. Res. 2005, 164:474-480.
7. Durante M., Snigiryova G., Akaeva E., Bogomazova A., Druzhinin S., Federenko B., Greco O., Novitskaya N., Rubanovich A., Shevchenko V., Von Recklinghausen U., Obe G. Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet. Genome Res. 2003, 103(1-2):40-46.
8. Wu H., George K., Yang T.C. Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. Int. J. Radiat. Biol. 1998, 73:521-527.
9. Lucas J.N., Awa A., Struame T., Poggesee M., Kodama Y., Nakamo M., Ontaki K., Weier U., Pinkel D., Gray J., Littlefield G. Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 1992, 62:53-63.
10. Pressl S., Edwards A.A., Stephan G. The influence of age, sex and smoking habits on the background level of fish-detected translocations. Mutat. Res. 1999, 442:89-95.
11. Tucker J.D., Moore D.H. The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents. Environ. Health Perspect. 1996, 104:489-492.
12. Edwards A.A. The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiat. Res. 1997, 148:S39-44.
13. Durante M., George K., Wu H., Cucinotta F.A. Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 2002, 158:581-590.
14. Loucas B.D., Cornforth M.N. Complex chromosome exchanges induced by gamma rays in human lymphocytes: an mFISH study. Radiat. Res. 2001, 155:660-671.
15. Lloyd D.C., Moquet J.F., Oram S., Edwards A.A., Lucas J.N. Accidental intake of tritiated water: a cytogenetic follow-up case on translocation stability and dose reconstruction. Int. J. Radiat. Biol. 1998, 73:543-547.
16. Lindholm C., Edward A. Long-term persistence of translocations in stable lymphocytes from victims of a radiological accident. Int. J. Radiat. Biol. 2004, 80:559-566.
17. 137Cesium-induced chromosome aberrations analyzed by fluorescence in situ hybridization: eight year follow up of the goiania radiation accident victims. Mutat. Res. 1998, 400(1-2):299-312.
18. Huber R., Braselmann H., Kulka U., Schumacher-Georgiadou V., Bayerl A., Mols M., Bauchinger M. Follow-up analysis of translocation and dicentric frequencies measured by FISH-chromosome painting in breast cancer patients after partial-body radiotherapy with little bone marrow exposure. Mutat. Res. 1999, 446:103-109.
19. Bauchinger M., Schmid E., Braselmann H. Time-course of translocation and dicentric frequencies in a radiation accident case. Int. J. Radiat. Biol. 2001, 77(5):553-557.
20. Cucinotta F.A., Durante M. Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol. 2006, 7(5):431-435.
21. Taylor G.R., Konstantinova I., Sonnenfeld G., Jennings R. Changes in the immune system during and after spaceflight. Adv. Space Biol. Med. 1997, 6:1-32.