Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting

Radiation Research

Volumn 164, Issue 4 II, 2005, Pages 474-480

  George, K ^a,b   Willingham, V ^a,b   Cucinotta, F A ^b  

^a WYLE LABORATORIES   (United States)

^b NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME ABERRATION; CHROMOSOME PAINTING; CLINICAL ARTICLE; CONFERENCE PAPER; COSMONAUT; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC STABILITY; GENETIC VARIABILITY; HALF LIFE TIME; HUMAN; LYMPHOCYTE; MEASUREMENT; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RISK ASSESSMENT; SPACE FLIGHT; TIME SERIES ANALYSIS;

NASA CENTER JSC; NASA DISCIPLINE RADIATION HEALTH;

ASTRONAUTS; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; COSMIC RADIATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; SPACE FLIGHT; TRANSLOCATION, GENETIC;

EID: 25444517286     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3323.1     Document Type: Conference Paper

References (32)

1. D. Pinkel, J. Landegent, C. Collins, J. Fuscoe, R. Segraves, J. Lucas and J. Gray, Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA 85, 9138-9142 (1988).
2. J. N. Lucas, M. Poggensee and T. Straume, The persistence of chromosome translocations in a radiation worker accidentally exposed to tritium. Cytogenet. Cell Genet. 60, 255-256 (1992).
3. J. N. Lucas, A. Awa, T. Struame, M. Poggensee, Y. Kodama, M. Nakamo, K. Ontaki, U. Weier, D. Pinkel and G. Littlefield, Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 62, 53-63 (1992).
4. D. C. Lloyd, J. F. Moquet, S. Oram, A. A. Edwards and J. N. Lucas, Accidental intake of tritiated water: A cytogenetic follow-up case on translocation stability and dose reconstruction. Int. J. Radiat. Biol. 73, 543-547 (1998).
5. J. N. Lucas, F. S. Hill, C. E. Burk, A. B. Cox and T. Straume, Stability of the translocation frequency following whole-body irradiation measured in rhesus monkeys. Int. J. Radiat. Biol. 70, 309-318 (1996).
6. R. Huber, H. Braselmann, U. Kulka, V. Schumacher-Georgiadou, A. Bayerl, M. Mols and M. Bauchinger, Follow-up analysis of translocation and dicentric frequencies measured by FISH-chromosome painting in breast cancer patients after partial-body radiotherapy with little bone marrow exposure. Mutat. Res. 446, 103-109 (1999).
7. C. Lindholm, H. Romm, G. Stephan, E. Schmid, J. Moquet and A. Edwards, Intercomparison of translocation and dicentric frequencies between laboratories in a follow-up of the radiological accident in Estonia. Int. J. Radiat. Biol. 78, 883-890 (2003).
8. M. Bauchinger, E. Schmid and H. Braselmann, Time-course of translocation and dicentric frequencies in a radiation accident case. Int. J. Radiat. Biol. 77, 553-557 (2001).
9. 137Cesium-induced chromosome aberrations analyzed by fluorescence in situ hybridization: Eight year follow up of the Goiania radiation accident victims. Mutat. Res. 400, 299-312 (1998).
10. K. Matsumoto, M. J. Ramsey, D. O. Nelson and J. D. Tucker, Persistence of radiation-induced translocations in human peripheral blood determined by chromosome painting. Radiat. Res. 149, 602-613 (1998).
11. S. Pressl, A. Edwards and G. Stephan, The influence of age, sex and smoking habits on the background level of FISH-detected translocations. Mutat. Res. 442, 89-95 (1999).
12. J. D. Tucker and D. H. Moore, The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents. Environ. Health Perspect. 104, 489-492 (1996).
13. M. Durante, K. George, H. Wu and F. A. Cucinotta, Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 158, 581-590 (2002).
14. K. M. Greulich, L. Kreja, B. Heinze, A. P. Rhein, H. Weier, M. Bruckner, P. Fuchs and M. Molls, Rapid detection of radiation-induced chromosomal aberrations in lymphocytes and hematopoietic progenitor cells by mFISH. Mutat. Res. 452, 73-81 (2000).
15. B. D. Loucas and M. N. Cornforth, Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiat. Res. 155, 660-671 (2001).
16. T. C. Yang, K. George, A. S. Johnson, M. Durante and B. S. Federenko, Biodosimetry results from space flight Mir-18. Radiat. Res. 148, 17-23 (1997).
17. K. George, M. Durante, H. Wu, V. Willingham, G. Badhwar and F. A. Cucinotta, Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res. 156, 731-738 (2001).
18. O. Greco, M. Durante, G. Gialanella, G. Grossi, M. Pugliese, P. Scampoli, G. Snigiryova and G. Obe, Biological dosimetry in Russian and Italian astronauts. Adv. Space Res. 31, 1495-1503 (2003).
19. G. Obe, I. Johannes, C. Johannes, K. Hallman, G. Reitz and R. Facius, Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int. J Radiat. Biol. 72, 727-734 (1997).
20. I. Testard, M. Ricoul, F. Hoffschir, A. Flury-Herard, B. Dutrillaux, B. Federenko, V. Gerasimenko and L. Sabatier, Radiation-induced chromosome damage in astronauts' lymphocytes. Int. J. Radiat. Biol. 70, 403-411 (1996).
21. B. Federenko, S. Druzhinin, L. Yudaeva, V. Petrov, Y. Akatov, G. Snigiryova, N. Novitskaya, V. Shevchenko and A. Rubanovich, Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station. Adv. Space Res. 27, 355-359 (2001).
22. F. A. Cucinotta, J. W. Wilson, J. R. Williams and J. F. Dicello, Analysis of MIR-18 results for physical and biological dosimetry: Radiation shielding effectiveness in LEO. Radiat. Meas. 32, 181-191 (2000).
23. M. Durante, Y. Furusawa and E. Gotoh, A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. Int. J. Radiat. Biol. 74, 457-462 (1998).
24. K. Morimoto and S. Wolff, Cell cycle kinetics in human lymphocyte cultures. Nature 288, 604-606 (1980).
25. H. Wu, K. George and T. C. Yang, Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. Int. J. Radiat. Biol. 73, 521-527 (1998).
26. G. Obe, P. Pfeiffer, J. R. K. Savage, C. Johannes, W. Goedecke, P. Jeppesen, A. T. Natarajan, W. Martinez-Lopez, G. A. Folle and M. E. Drets, Chromosomal aberrations: Formation, identification and distribution. Mutat. Res. 504, 17-36 (2002).
27. A. T. Natarajan, R. C. Vyas, J. Wiegant and M. P. Curado, Cytogenetic follow-up study of the victims of a radiation accident in Goiania (Brazil). Mutat. Res. 247, 103-111 (1991).
28. F. A. Cucinotta, H. Nikjoo and D. Goodhead, The effects of delta rays on the number of particle-track traversals per cell in laboratory and space exposures. Radiat. Res. 150, 115-119 (1998).
29. P. Todd, M. J. Pecaut and M. Fleshner, Combined effects of space flight factors and radiation on humans. Mutat. Res. 430, 211-221 (1999).
30. G. R. Taylor, I. Konstantinova, G. Sonnenfeld and R. Jennings, Changes in the immune system during and after spaceflight. Adv. Space Biol. Med. 6, 1-32 (1997).
31. M. Durante, G. Snigiryova, E. Akaeva, A. Bogomazova, S. Druzhinin, B. Federenko, O. Greco, N. Novitskaya, A. Rubanovich and G. Obe, Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet. Genome Res. 103, 40-46 (2003).
32. M. A. Kadhim, D. A. MacDonald, D. T. Goodhead, S. A. Lorimore, S. A. Marsden and E. G. Wright, Transmission of chromosomal instability after plutonium alpha particle irradiation. Nature 355, 738-740 (1992).