Dominant cone-rod dystrophy: A mouse model generated by gene targeting of the GCAP1/Guca1a gene

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Buch, Prateek K ^a   Mihelec, Marija ^a   Cottrill, Phillippa ^a   Wilkie, Susan E ^a   Pearson, Rachael A ^a   Duran, Yanai ^a   West, Emma L ^a   Michaelides, Michel ^a   Ali, Robin R ^a   Hunt, David M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CONE OPSIN; CYCLIC GMP; GUANYLATE CYCLASE ACTIVATING PROTEIN 1; GUANYLATE CYCLASE ACTIVATOR; SCOTOPSIN; UNCLASSIFIED DRUG; GUCA1A PROTEIN, MOUSE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONE DYSTROPHY 3; CONTROLLED STUDY; DISEASE COURSE; ELECTRORETINOGRAPHY; GCAP1 GENE; GENE; GENE FUNCTION; GENE TARGETING; GUCA1A GENE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOGENESIS; PHOTORECEPTOR; POINT MUTATION; RETINA DEGENERATION; ANIMAL; ASYMPTOMATIC DISEASE; DISEASE MODEL; DOMINANT GENE; GENETICS; HUMAN; INTRACELLULAR SPACE; KINETICS; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; RETINA CONE; RETINA ROD; RETINITIS PIGMENTOSA;

MURINAE; MUS;

ANIMALS; ASYMPTOMATIC DISEASES; CYCLIC GMP; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; GENE KNOCK-IN TECHNIQUES; GENE TARGETING; GENES, DOMINANT; GUANYLATE CYCLASE-ACTIVATING PROTEINS; HUMANS; INTRACELLULAR SPACE; KINETICS; MICE; MUTANT PROTEINS; MUTATION; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA;

EID: 79953134438     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018089     Document Type: Article

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