RGS9-1 is required for normal inactivation of mouse cone phototransduction

Molecular Vision

Volumn 7, Issue , 2001, Pages 71-78

  Lyubarsky, A L ^a   Chen, C K ^b   Naarendorp, F ^c   Zhang, X ^d   Wensel, T ^d   Simon, M I ^e   Pugh Jr , E N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; MONOCLONAL ANTIBODY; PEANUT AGGLUTININ; RGS PROTEIN; RHODAMINE;

A WAVE; ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B WAVE; CLINICAL PROTOCOL; CONDITIONING; CONTROLLED STUDY; CORNEA SENSIBILITY; DARK ADAPTATION; ELECTRORETINOGRAPHY; GENE INACTIVATION; GENERATOR; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOTOTRANSDUCTION; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA CONE; ULTRAVIOLET RADIATION; WILD TYPE;

ANIMALS; CONES (RETINA); ELECTRORETINOGRAPHY; FLUORESCEIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MICE; MICE, INBRED C57BL; PHOTIC STIMULATION; PHOTOTRANSDUCTION; RGS PROTEINS; RHODAMINES;

EID: 0347264904     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Pugh EN Jr, Lamb TD. Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification, recovery and light adaptation. In: Stavenga DG, de Grip WJ, Pugh EN Jr, editors. Molecular mechanisms in visual transduction. Amsterdam: Elsevier; 2000. p. 183-255.
2. Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet 1997; 15:175-8.
3. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A 1998; 95:328-33.
4. He W, Cowan CW, Wensel TG. RGS9, a GTPase accelerator for phototransduction. Neuron 1998; 20:95-102.
5. Cowan CW, Wensel TG, Arshavsky VY. Enzymology of GTPase acceleration in phototransduction. Methods Enzymol 2000; 315:524-38.
6. Makino ER, Handy JW, Li T, Arshavsky VY. The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. Proc Natl Acad Sci U S A 1999; 96:1947-52.
7. Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA. Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem 2000; 275:3397-402.
8. Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature 2000; 403:557-60.
9. Lyubarsky AL, Chen C, Simon MI, Pugh EN. Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci 2000; 20:2209-17.
10. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A 1998; 95:5351-6.
11. Pugh EN Jr, Falsini B, Lyubarsky AL. The origin of the major rod- and cone-driven components of the rodent electroretinogram and the effect of age and light-rearing history on the magnitude of these components. In: Williams TP, Thistle AB, editors. Photostasis and related phenomena. New York: Plenum Press; 1998. p. 93-128.
12. Lyubarsky AL, Falsini B, Pennesi ME, Valentini P, Pugh EN. UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments. J Neurosci 1999; 19:442-55.
13. Watson AJ, Aragay AM, Slepak VZ, Simon MI. A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina. J Biol Chem 1996; 271:28154-60.
14. Blanks JC, Johnson LV. Specific binding of peanut lectin to a class of retinal photoreceptor cells. A species comparison. Invest Ophthalmol Vis Sci 1984; 25:546-57.
15. Calderone JB, Jacobs GH. Regional variations in the relative sensitivity to UV light in the mouse retina. Vis Neurosci 1995; 12:463-8.
16. Jacobs GH, Neitz J, Deegan JF 2nd. Retinal receptors in rodents maximally sensitive to ultraviolet light. Nature 1991; 353:655-6.
17. Hood DC, Birch DG. Phototransduction in human cones measured using the alpha-wave of the ERG. Vision Res 1995; 35:2801-10.
18. Cideciyan AV, Jacobson SG. An alternative phototransduction model for human rod and cone ERG a-waves: normal parameters and variation with age. Vision Res 1996; 36:2609-21.
19. Smith NP, Lamb TD. The a-wave of the human electroretinogram recorded with a minimally invasive technique. Vision Res 1997; 37:2943-52.
20. Sieving PA, Murayama K, Naarendorp F. Push-pull model of the primate photopic electroretinogram: a role for hyperpolarizing neurons in shaping the b-wave. Vis Neurosci 1994; 11:519-32.
21. Bush RA, Sieving PA. Inner retinal contributions to the primate photopic fast flicker electroretinogram. J Opt Soc Am A 1996; 13:557-65.
22. Robinson SW, Garbers DL. Genetic models to study guanylyl cyclase function. Methods Enzymol 2000; 316:558-64.
23. Yang RB, Robinson SW, Xiong WH, Yau KW, Birch DG, Garbers DL. Disruption of a retinal guanylyl cyclase gene leads to cone-specific dystrophy and paradoxical rod behavior. J Neurosci 1999; 19:5889-97.
24. Howes K, Bronson JD, Dang YL, Li N, Zhang K, Ruiz C, Helekar B, Lee M, Subbaraya I, Kolb H, Chen J, Baehr W. Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Invest Ophthalmol Vis Sci 1998; 39:867-75.
25. Polans A, Baehr W, Palczewski K. Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci 1996; 19:547-54.
26. Pugh EN, Duda T, Sitaramayya A, Sharma RK. Photoreceptor guanylate cyclases: a review. Biosci Rep 1997; 17:429-73.
27. Dizhoor AM, Hurley JB. Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins. Methods 1999; 19:521-31.
28. Dizhoor AM, Boikov SG, Olshevskaya EV. Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration. J Biol Chem 1998; 273:17311-4.
29. Wachtmeister L. Oscillatory potentials in the retina: what do they reveal? Prog Retin Eye Res 1998; 17:485-521.
30. Thomas MM, Lamb TD. Light adaptation and dark adaptation of human rod photoreceptors measured from the a-wave of the electroretinogram. J Physiol 1999; 518:479-96.