Sub-cellular internalization and organ specific oral elivery of PABA nanoparticles by side chain variation

Journal of Nanobiotechnology

Volumn 9, Issue , 2011, Pages

  Yadav, Jhillu S ^a   Das, Pragna P ^a   Reddy, T Lakshminarayan ^a   Bag, Indira ^a   Lavanya, Priyadarshini M ^b   Jagannadh, Bulusu ^a   Mohapatra, Debendra K ^a   Bhadra, Manika P ^a   Bhadra, Utpal ^b  

^a Indian Institute of Chemical Technology Uppal Road ^*  (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACID CHAINS; ANIMAL MODEL; BIOLOGICAL APPLICATIONS; BIOLOGICAL PROPERTIES; COMPLEX ORGANS; COMPLEX TISSUES; ENERGY DEPENDENT; FLUROPHORES; HOST CELLS; HUMAN CELL LINES; IN-VIVO; INSECT CELLS; INTERNAL ORGANS; LIVE CELL; NANO-MATERIALS; NANOMATERIAL; ORGANIC NANOMATERIALS; PHYSICAL AND CHEMICAL PROPERTIES; PHYSIO-CHEMICAL; SELF-ASSEMBLED; SIDE CHAINS; SIZE AND SHAPE; SUB-CELLULAR; SURFACE TEXTURES;

CELL CULTURE; CHEMICAL PROPERTIES; MOLECULAR BIOLOGY; NANOPARTICLES; NANOSTRUCTURED MATERIALS; PHYSIOLOGY; TISSUE;

CELLS;

4 AMINOBENZOIC ACID; CARBON; CARBON 11; CARBON 16; UNCLASSIFIED DRUG; NANOPARTICLE;

ARTICLE; CELL FUNCTION; DROSOPHILA; ENDOCYTOSIS; NONHUMAN; PHYSICAL CHEMISTRY; ANIMAL; CELL LINE; CHEMISTRY; HUMAN; METABOLISM; ORAL DRUG ADMINISTRATION;

ANIMALIA; HEXAPODA;

4-AMINOBENZOIC ACID; ADMINISTRATION, ORAL; ANIMALS; CELL LINE; DROSOPHILA; ENDOCYTOSIS; HUMANS; NANOPARTICLES;

EID: 79953114921     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-9-10     Document Type: Article

References (25)

1. Whitesides GM. The ''right'' size in nanobiotechnology. Nat Biotech 2003, 21:1161-1165.
2. Sinha R, Kim GJ, Shin DM. Nanotechnology in cancer therapeutics: Bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006, 5:1909-1917. 10.1158/1535-7163.MCT-06-0141, 16928810.
3. Alivisatos P. The use of nanocrystals in biological detection. Nat Biotechnol 2004, 22:47-52. 10.1038/nbt927, 14704706.
4. Taton T, Mirkin C, Letsinger R. Scanometric DNA array detection with nanoparticle probes. Science 2000, 289:1757-1760. 10.1126/science.289.5485.1757, 10976070.
5. Cui Y, Wei Q, Lieber C. Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science 2001, 293:1289-1292. 10.1126/science.1062711, 11509722.
6. Dai H. Carbon nanotubes: Synthesis, integration, and properties. Acc Chem Res 2002, 35:1035-1044. 10.1021/ar0101640, 12484791.
7. Kamiya H, Tsuchiya H, Yamazaki J, Harashima H. Intracellular trafficking and transgene expression of viral and non-viral gene vectors. Adv Drug Deliv Rev 2001, 52:153-164. 10.1016/S0169-409X(01)00216-2, 11718940.
8. Zabner J, Fasbender AJ, Moninger T, Welsh MJ. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995, 270:18997-19007. 10.1074/jbc.270.32.18997, 7642560.
9. Zheng G, Chen J, Li H, Glickson JD. Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents. Proc Natl Acad Sci USA 2005, 102:17757-17762. 10.1073/pnas.0508677102, 1308912, 16306263.
10. Wu Y, Xiang J, Yang C, Lu W, Lieber CM. Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures. Nature 2004, 430:61-65. 10.1038/nature02674, 15229596.
11. Akerman ME, Laakkonen P, Bhatia SN, Ruoslahti E. Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 2002, 99:12617-12621. 10.1073/pnas.152463399, 130509, 12235356.
12. Yadav JS, Das PP, Krishnan A, Mohapatra DK, Bhadra MP, Bhadra U. 4-N-pyridine-2-yl benzamide nanotubes compatible with mouse stem cell and oral delivery in Drosophila. Nanotechnology 2010, 21:155102. 10.1088/0957-4484/21/15/155102, 20332564.
13. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol 2005, 23:1418-1423. 10.1038/nbt1159, 16244656.
14. Schreiber SL. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 2000, 287:1964-1969. 10.1126/science.287.5460.1964, 10720315.
15. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Ostroff GR, Czech MP. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 2009, 458:1180-1184. 10.1038/nature07774, 2879154, 19407801.
16. Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008, 319:627-630. 10.1126/science.1149859, 2490797, 18239128.
17. Guha S, Drew MGB, Banerjee A. Dipeptide Nanotubes, with N-Terminally Located ω-Amino Acid Residues, That are Stable Proteolytically, Thermally, and Over a Wide Range of pH. Chem Mater 2008, 20:2282-2290.
18. Heuser J, Anderson RGW. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol 1989, 108:389-400. 10.1083/jcb.108.2.389, 2115439, 2563728.
19. Larkin JM, Brown MS, Goldstein JL, Anderson RGW. Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell 1983, 33:273-285. 10.1016/0092-8674(83)90356-2, 6147196.
20. Liu X, Vinson D, Abt D, Hurt RH, Rand DM. Differential toxicity of carbon nanomaterials in Drosophila: larval dietary uptake is benign, but adult exposure causes locomotor impairment and mortality. Environ Sci Technol 2009, 43:6357-6363. 10.1021/es901079z, 19746737.
21. Leeuw TK, Reith RM, Simonette RA, Harden ME, Cherukuri P, Tsyboulski DA, Beckingham KM, Weisman RB. Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila. Nano Lett 2007, 7:2650-2654. 10.1021/nl0710452, 17696559.
22. Qaddoumi MG, Gukasyan HJ, Davda J, Labhasetwar V, Kim KJ, Lee VH. Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis. Mol Vision 2003, 9:559-568.
23. Madshus IH, Sandvig K, Olsnes S, van Deurs B. Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses. J Cell Physiol 1987, 131:14-22. 10.1002/jcp.1041310104, 3032992.
24. Plumb JA, Milroy R, Kaye SB. Effects of the pH dependence of 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 1989, 49:4435-4440.
25. Pal-Bhadra M, Bhadra U, Kundu J, Birchler JA. Gene expression analysis of the function of the male specific lethal complex in Drosophila. Genetics 2005, 169:2061-2074. 10.1534/genetics.104.036020, 1449592, 15716510.