Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians

Retrovirology

Volumn 8, Issue , 2011, Pages

  Malhotra, Rakhi ^a   Hu, Liangyuan ^a   Song, Wei ^a   Brill, Ilene ^a   Mulenga, Joseph ^c   Allen, Susan ^c,d   Hunter, Eric ^d   Shrestha, Sadeep ^a   Tang, Jianming ^b   Kaslow, Richard A ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c Rwanda Zambia HIV 1 Research Group   (Zambia)

^d EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; VIRUS RNA; CCR2 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5;

ADULT; AGE; ARTICLE; CHEMOKINE RECEPTOR CCR2 GENE; CHEMOKINE RECEPTOR CCR5 GENE; COHORT ANALYSIS; CONTROLLED STUDY; DIPLOTYPE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENITAL ULCER; GENOTYPE; HAPLOTYPE; HETEROSEXUALITY; HOMOZYGOTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; RECEPTOR GENE; SEROCONVERSION; SEX DIFFERENCE; UROGENITAL TRACT INFECTION; VIRUS LOAD; VIRUS TRANSMISSION; ZAMBIA; DISEASE COURSE; DISEASE TRANSMISSION; FAMILY SIZE; GENE FREQUENCY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEGRO; PATHOGENICITY; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; DISEASE PROGRESSION; FAMILY CHARACTERISTICS; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HIV INFECTIONS; HIV-1; HUMANS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, CCR2; RECEPTORS, CCR5; VIRAL LOAD; YOUNG ADULT; ZAMBIA;

EID: 79953111514     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-8-22     Document Type: Article

References (45)

1. UNAIDS UNAIDS/WHO "AIDS Epidemic Update: December 2006". Book UNAIDS/WHO "AIDS Epidemic Update: December 2006" 2006, City, (Editor ed.^eds.), UNAIDS.
2. Dunkle KL, Stephenson R, Karita E, Chomba E, Kayitenkore K, Vwalika C, Greenberg L, Allen S. New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda: an analysis of survey and clinical data. Lancet 2008, 371:2183-2191. 10.1016/S0140-6736(08)60953-8, 18586173.
3. Borrow P, Shattock RJ, Vyakarnam A. Innate immunity against HIV: a priority target for HIV prevention research. Retrovirology 2010, 7:84. 10.1186/1742-4690-7-84, 2964587, 20937128.
4. Royce RA, Sena A, Cates W, Cohen MS. Sexual transmission of HIV. N Engl J Med 1997, 336:1072-1078. 10.1056/NEJM199704103361507, 9091805.
5. Ping LH, Nelson JA, Hoffman IF, Schock J, Lamers SL, Goodman M, Vernazza P, Kazembe P, Maida M, Zimba D, et al. Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants. J Virol 1999, 73:6271-6281. 112705, 10400718.
6. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996, 86:367-377. 10.1016/S0092-8674(00)80110-5, 8756719.
7. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996, 382:722-725. 10.1038/382722a0, 8751444.
8. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996, 273:1856-1862. 10.1126/science.273.5283.1856, 8791590.
9. Zimmerman PA, Buckler-White A, Alkhatib G, Spalding T, Kubofcik J, Combadiere C, Weissman D, Cohen O, Rubbert A, Lam G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997, 3:23-36. 2230106, 9132277.
10. McDermott DH, Zimmerman PA, Guignard F, Kleeberger CA, Leitman SF, Murphy PM. CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet 1998, 352:866-870. 10.1016/S0140-6736(98)04158-0, 9742978.
11. Tang J, Shelton B, Makhatadze NJ, Zhang Y, Schaen M, Louie LG, Goedert JJ, Seaberg EC, Margolick JB, Mellors J, Kaslow RA. Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J Virol 2002, 76:662-672. 10.1128/JVI.76.2.662-672.2002, 136835, 11752157.
12. Winkler CA, Hendel H, Carrington M, Smith MW, Nelson GW, O'Brien SJ, Phair J, Vlahov D, Jacobson LP, Rappaport J, et al. Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression. J Acquir Immune Defic Syndr 2004, 37:1534-1538. 10.1097/01.qai.0000127353.01578.63, 15602133.
13. Ometto L, Bertorelle R, Mainardi M, Zanchetta M, Tognazzo S, Rampon O, Ruga E, Chieco-Bianchi L, De Rossi A. Polymorphisms in the CCR5 promoter region influence disease progression in perinatally human immunodeficiency virus type 1-infected children. J Infect Dis 2001, 183:814-818. 10.1086/318828, 11181160.
14. Tang J, Shao W, Yoo YJ, Brill I, Mulenga J, Allen S, Hunter E, Kaslow RA. Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples. J Immunol 2008, 181:2626-2635. 2570252, 18684953.
15. Allen S, Meinzen-Derr J, Kautzman M, Zulu I, Trask S, Fideli U, Musonda R, Kasolo F, Gao F, Haworth A. Sexual behavior of HIV discordant couples after HIV counseling and testing. Aids 2003, 17:733-740. 10.1097/00002030-200303280-00012, 12646797.
16. Trask SA, Derdeyn CA, Fideli U, Chen Y, Meleth S, Kasolo F, Musonda R, Hunter E, Gao F, Allen S, Hahn BH. Molecular epidemiology of human immunodeficiency virus type 1 transmission in a heterosexual cohort of discordant couples in Zambia. J Virol 2002, 76:397-405. 10.1128/JVI.76.1.397-405.2002, 135722, 11739704.
17. Gonzalez E, Bamshad M, Sato N, Mummidi S, Dhanda R, Catano G, Cabrera S, McBride M, Cao XH, Merrill G, et al. Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci USA 1999, 96:12004-12009. 10.1073/pnas.96.21.12004, 18402, 10518566.
18. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, et al. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 2005, 307:1434-1440. 10.1126/science.1101160, 15637236.
19. Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 1997, 277:959-965. 10.1126/science.277.5328.959, 9252328.
20. Easterbrook PJ, Rostron T, Ives N, Troop M, Gazzard BG, Rowland-Jones SL. Chemokine receptor polymorphisms and human immunodeficiency virus disease progression. J Infect Dis 1999, 180:1096-1105. 10.1086/314997, 10479136.
21. Kageyama S, Mimaya J, Yamada K, Kurimura T, Shiraki K. Polymorphism of CCR5 affecting HIV disease progression in the Japanese population. AIDS Res Hum Retroviruses 2001, 17:991-995. 10.1089/088922201300343663, 11485615.
22. Ioannidis JP, Rosenberg PS, Goedert JJ, Ashton LJ, Benfield TL, Buchbinder SP, Coutinho RA, Eugen-Olsen J, Gallart T, Katzenstein TL, et al. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med 2001, 135:782-795.
23. Schinkel J, Langendam MW, Coutinho RA, Krol A, Brouwer M, Schuitemaker H. No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. J Infect Dis 1999, 179:825-831. 10.1086/314658, 10068577.
24. Dorak MT, Tang J, Penman-Aguilar A, Westfall AO, Zulu I, Lobashevsky ES, Kancheya NG, Schaen MM, Allen SA, Kaslow RA. Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples. Lancet 2004, 363:2137-2139. 10.1016/S0140-6736(04)16505-7, 15220037.
25. Nguyen L, Li M, Chaowanachan T, Hu DJ, Vanichseni S, Mock PA, van Griensven F, Martin M, Sangkum U, Choopanya K, et al. CCR5 promoter human haplogroups associated with HIV-1 disease progression in Thai injection drug users. Aids 2004, 18:1327-1333. 10.1097/00002030-200406180-00012, 15362666.
26. An P, Martin MP, Nelson GW, Carrington M, Smith MW, Gong K, Vlahov D, O'Brien SJ, Winkler CA. Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans. Aids 2000, 14:2117-2122. 10.1097/00002030-200009290-00007, 11061652.
27. O'Brien SJ, Moore JP. The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol Rev 2000, 177:99-111.
28. Martin MP, Dean M, Smith MW, Winkler C, Gerrard B, Michael NL, Lee B, Doms RW, Margolick J, Buchbinder S, et al. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 1998, 282:1907-1911. 10.1126/science.282.5395.1907, 9836644.
29. Mummidi S, Ahuja SS, Gonzalez E, Anderson SA, Santiago EN, Stephan KT, Craig FE, O'Connell P, Tryon V, Clark RA, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med 1998, 4:786-793. 10.1038/nm0798-786, 9662369.
30. Ma L, Marmor M, Zhong P, Ewane L, Su B, Nyambi P. Distribution of CCR2-64I and SDF1-3'A alleles and HIV status in 7 ethnic populations of Cameroon. J Acquir Immune Defic Syndr 2005, 40:89-95. 10.1097/01.qai.0000157008.66584.d6, 16123688.
31. Arenzana-Seisdedos F, Parmentier M. Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands. Semin Immunol 2006, 18:387-403. 10.1016/j.smim.2006.07.007, 16978874.
32. Joubert BR, Franceschini N, Mwapasa V, North KE, Meshnick SR. Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi. PLoS One 2010, 5:e9212. 10.1371/journal.pone.0009212, 2821402, 20169157.
33. Kostrikis LG, Neumann AU, Thomson B, Korber BT, McHardy P, Karanicolas R, Deutsch L, Huang Y, Lew JF, McIntosh K, et al. A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants. J Virol 1999, 73:10264-10271. 113080, 10559343.
34. Valdez H, Purvis SF, Lederman MM, Fillingame M, Zimmerman PA. Association of the CCR5delta32 mutation with improved response to antiretroviral therapy. Jama 1999, 282:734. 10.1001/jama.282.8.734, 10463706.
35. Kasten S, Goldwich A, Schmitt M, Rascu A, Grunke M, Dechant C, Kalden JR, Harrer T. Positive influence of the Delta32CCR5 allele on response to highly active antiretroviral therapy (HAART) in HIV-1 infected patients. Eur J Med Res 2000, 5:323-328.
36. Barroga CF, Raskino C, Fangon MC, Palumbo PE, Baker CJ, Englund JA, Spector SA. The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment. J Infect Dis 2000, 182:413-419. 10.1086/315704, 10915070.
37. Wang YM, Wang B, Dyer WB, Lachireddy K, Peng NK, Saksena NK. Evidence for predominance of CCR5-using HIV-1 strains during highly active antiretroviral therapy. Curr HIV Res 2007, 5:221-234. 10.2174/157016207780077048, 17346136.
38. Puissant B, Roubinet F, Massip P, Sandres-Saune K, Apoil PA, Abbal M, Pasquier C, Izopet J, Blancher A. Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte counts. AIDS Res Hum Retroviruses 2006, 22:153-162. 10.1089/aid.2006.22.153, 16478397.
39. Catano G, Chykarenko ZA, Mangano A, Anaya JM, He W, Smith A, Bologna R, Sen L, Clark RA, Lloyd A, et al. Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates. J Infect Dis 2011, 203:263-272. 10.1093/infdis/jiq023, 21288827.
40. Fideli US, Allen SA, Musonda R, Trask S, Hahn BH, Weiss H, Mulenga J, Kasolo F, Vermund SH, Aldrovandi GM. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses 2001, 17:901-910. 10.1089/088922201750290023, 2748905, 11461676.
41. Tang J, Tang S, Lobashevsky E, Zulu I, Aldrovandi G, Allen S, Kaslow RA. HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners. AIDS Res Hum Retroviruses 2004, 20:19-25. 10.1089/088922204322749468, 15000695.
42. Mangano A, Gonzalez E, Dhanda R, Catano G, Bamshad M, Bock A, Duggirala R, Williams K, Mummidi S, Clark RA, et al. Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus. J Infect Dis 2001, 183:1574-1585. 10.1086/320705, 11335892.
43. Pedersen BR, Kamwendo D, Blood M, Mwapasa V, Molyneux M, North K, Rogerson SJ, Zimmerman P, Meshnick SR. CCR5 haplotypes and mother-to-child HIV transmission in Malawi. PLoS One 2007, 2:e838. 10.1371/journal.pone.0000838, 1950791, 17786209.
44. John GC, Bird T, Overbaugh J, Nduati R, Mbori-Ngacha D, Rostron T, Dong T, Kostrikis L, Richardson B, Rowland-Jones SL. CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality. J Infect Dis 2001, 184:89-92. 10.1086/321006, 11398114.
45. Ramaley PA, French N, Kaleebu P, Gilks C, Whitworth J, Hill AV. HIV in Africa (Communication arising): chemokine-receptor genes and AIDS risk. Nature 2002, 417:140. 10.1038/417140a, 12000952.