Chemokine receptor polymorphisms and human immunodeficiency virus disease progression

Journal of Infectious Diseases

Volumn 180, Issue 4, 1999, Pages 1096-1105

  Easterbrook, Philippa J ^a   Rostron, Tim ^c   Ives, Natalie ^a   Troop, Maxine ^b   Gazzard, Brian G ^b   Rowland Jones, Sarah L ^c  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5;

ARTICLE; DISEASE COURSE; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION;

BISEXUALITY; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; DISEASE PROGRESSION; DNA PRIMERS; GENOTYPE; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HOMOSEXUALITY, MALE; HUMANS; MALE; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; PROMOTER REGIONS (GENETICS); PROPORTIONAL HAZARDS MODELS; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; TIME FACTORS;

EID: 0033402361     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314997     Document Type: Article

References (34)

1. Easterbrook PJ, Schrager LK. Long-term nonprogression in HIV infection: methodological issues and scientific priorities. Report of an international European community. National Institutes of Health Workshop, The Royal Society, London, England, 1995 November 27-29. Scientific Coordinating Committee. AIDS Res Hum Retroviruses 1998; 14:1211-28.
2. Rowland-Jones SL, Long-term non-progression in HIV infection; clinico-pathological issues. J Infection 1999; 38:67-70.
3. O'Brien SJ, Dean M. In search of AIDS-resistance genes. Sci Am 1997; 277:44-51.
4. Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4 cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-73.
5. Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5 : a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272:1955-8.
6. Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses Fusin and the β-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors. Cell 1996; 85:1149-58.
7. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study. Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996; 273:1856-62.
8. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutani CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996; 2:1240-3.
9. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS). San Francisco City Cohort (SFCC), ALIVE Study. Science 1997; 277:959-65.
10. Michael NL, Chang G, Louie L, Mascola JR, Dondero D, Birx DL, Sheppard HW. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997; 3:338-40.
11. Zimmerman PA, Buckler WA, Alkhatib G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997; 3:23-36.
12. Eugen-Olsen J, Iversen AK, Garred P, et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. Aids 1997; 11:305-10.
13. Rappaport J, Cho YY, Hendel H, Schwartz EJ, Schachter F, Zagury JF. 32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes [letter]. Lancet 1997; 349:922-3.
14. Balfe P, Churcher Y, Penny M, et al. Association between a defective CCR-5 gene and progression to disease in HIV infection [in process citation], AIDS Res Hum Retroviruses 1998; 14:1229-34.
15. Rizzardi GP, Morawetz RA, Vicenzi E, et al. CCR2 polymorphism and HIV disease. Swiss HIV Cohort. Nat Med 1998; 4:252-3.
16. Kostrikis L, Huang Y, Moore JP, et al. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation, Nat Med 1998; 4:350-3.
17. Anzala AO, Ball TB, Rostron T, O'Brien SJ, Plummer FA, Rowland-Jones SL. University of Nairobi Collaboration for HIV Research. CCR2-641 allele and genotype association with delayed AIDS progression in African Women. Lancet 1998; 351:1632-3.
18. Michael NL, Louie LG, Rohrbaugh AL, Schultz KA, Dayhoff DE, Wang CE, Sheppard HW. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nat Med 1997; 3:1160-2.
19. Mummidi S, Ahuja SS, Gonzalez E, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med 1998; 4:786-93.
20. Eugen-Olsen J, Iversen AK, Benfield TL, Koppelhus U, Garred P. Chemokine receptor CCR2b 641 polymorphism and its relation to CD4 T- cell counts and disease progression in a Danish cohort of HIV-infected individuals. Copenhagen AIDS cohort. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 18:110-6.
21. Cohen OJ, Paolucci S, Bende SM, et al. CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32. J Virol 1998; 72:6215-7.
22. Winkler C, Modi W, Smith MW, et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC) [see comments]. Science 1998; 279:389-93.
23. McDermott DH, Zimmerman PA, Guignard F, Kleeberger CA, Leitman SF, Murphy PM. CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS) Lancet 1998; 352:866-70.
24. Martin MP, Dean M, Smith MW, et al. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 1998; 282:1907-11.
25. Easterbrook PJ, Bunce M, Sidebottom D, et al. HLA class 1 genes and long-term non-progression in HIV infection [abstract Tu.C.550]. In: XIth International Conference on AIDS, Vancouver, July 1996.
26. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet 1997, 16:100-3.
27. Cuzick J. A Wilcoxon-type test for trend. Statistics in Medicine 1985; 4:87-90.
28. Smith MW, Carrington M, Winkler C. Lomb D, Dean M, Huttley G, O'Brien SJ. CCR2 chemokine recoptor and AIDS progression. Nat Med 1997; 3:1052-3.
29. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 88:7-20.
30. Wu L, Paxton WA, Kassam N, et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro. J Exp Med 1997; 185:1681-92.
31. Frade JMR, Llorente M, Mellado M, et al. The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection J Clin Invest 1997; 100:497-502.
32. Lee B, Doranz BJ, Rana S, et al. Influence of the CCR2-V641 polymorphism on human immunodeficiency virus type I coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J Virol 1998; 72:7450-8.
33. Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. Change in coreceptor use correlates with disease progression in HIV-1 infected individuals. J Exp Med 1997; 185:621-8.
34. The incidence and prevalence of AIDS and prevalence of other severe HIV disease in England and Wales for 1995 to 1999: projections using data to the end of 1994. Commun Dis Rep CDR Rev 1996; 6:R1-R21.