CCR5 haplotypes and mother-to-child HIV transmission in Malawi

PLoS ONE

Volumn 2, Issue 9, 2007, Pages

  Pedersen, Bonnie R ^a   Kamwendo, Deborah ^a   Blood, Melinda ^b   Mwapasa, Victor ^c   Molyneux, Malcolm ^c   North, Kari ^a   Rogerson, Stephen J ^d   Zimmerman, Peter ^b   Meshnick, Steven R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MALAWI   (Malawi)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; LIGASE; NEVIRAPINE;

ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALAWI; MOTHER CHILD TRASMISSION; NEWBORN; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS LOAD; GENETICS; PHYLOGENY; PREGNANCY; PREGNANCY COMPLICATION; VERTICAL TRANSMISSION;

FEMALE; HAPLOTYPES; HIV INFECTIONS; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALAWI; PHYLOGENY; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RECEPTORS, CCR5;

EID: 41049089058     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000838     Document Type: Article

References (44)

1. UNAIDS (2004) AIDS Epidemic Update. Geneva: UNAIDS, 2004.
2. Bertolli J, St Louis ME, Simonds RJ, Nieburg P, Kamenga M, et al. (1996) Estimating the timing of mother-to-child transmission of human immunodeficiency virus in a breast-feeding population in Kinshasa, Zaire J Infect Dis 174: 722-726.
3. Rouzioux C, Costagliola D, Burgard M, Blanche S, Mayaux MJ, et al. (1995) Estimated timing of mother-to-child human immunodeficiency virus type I (HIV-1) transmission by use of a Markov model. The HIV Infection in Newborns French Collaborative Study Group. Am J Epidemiol 142: 1330-1337.
4. Arenzana-Seisdedos F, Parmentier M (2006) Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands. Semin Inummol 18: 387-403.
5. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, et al. (1996) The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HTV-1 isolates. Cell 85: 1135-1148.
6. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, et al: (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661-666.
7. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, et al. (1996) A dual-tropic primary HIV-1 isolate that uses fasin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149-1158.
8. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, et al. (1996) HTV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381: 667-673.
9. Alkhatib G, Combadiere C, Broder CC, FengY, Kennedy PE, et al. (1996) CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic, HIV-1. Science 272: 1955-1958.
10. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, et al. (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273: 1856-1862.
11. Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, et al. (1996) The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 2: 1240-1241
12. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, et al. (1996) Homezygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86: 367-377.
13. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, et al. (1996) Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382: 722-725.
14. Zimmerman PA, Bucklcr-White A, Alkhatib G, Spalding T, Kubofcik J, et al. (1997) Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 3: 23-36.
15. Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT (1997) Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J Biol Chem 272: 30603-30606.
16. Clegg AO, Ashton LJ, Biti RA, Badhwar P, Williamson P, et al. (2000) CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1 -infected long-term non-progressors. The Australian Long-Term Non-Progressor Study Group. Aids 14: 103-108.
17. Knudsen TB, Kristiansen TB, Katzenstein TL, Eugen-Olsen J (2001) Adverse effect of the CCR5 promoter -2459A allele on HIV-1 disease progression. J Med Virol 65: 441-444.
18. Kostrikis LG, Neumann AU, Thomson B, Korber BT, McHardy P, et al. (1999) A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants. J Virol 73: 10264-10271.
19. McDermott DH, Zimmerman PA, Guignard F, Kleeberger CA, Leitman SF, et al. (1998) CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet 352: 866-870.
20. Tang J, Shelton B, Makhatadze NJ, Zhang Y, Schaen M, et al. (2002) Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type I (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J Virol 76: 662-672.
21. Salkowitz JR, Bruse SE, Meyerson H, Valdez H, Mosier DE, et al. (2003) CCR5 promoter polymorphisin determines macrophage CCR5 density and magnitude of HTV-1 propagation in vitro. Clin Immunol 108: 234-240.
22. Hladik F, Liu H, Speelmon E, Livingston-Rosanoff D, Wilson S, et al. (2005) Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol 79: 11677-11684.
23. Kostrikis LG, Huang Y, Moore JP, Wolinsky SM, Zhang L, et al. (1998) A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med 4: 350-353.
24. Anzala AO, Ball TB, Rostron T, O'Brien SJ, Plummer FA, et al. (1998) Easterbrook University of Nairobi Collaboration for HIV Research. Lancet 35 1: 1632-1633.
25. Easterbrook PJ, Rostron T, Ives N, Troop M, Gazzard BG, et al. (1999) Chemokine receptor polymorphisms and human immunodeficiency virus disease progression. J Infect Dis 180: 1096-1105.
26. Eugen-Olsen J, Iversen AK, Benfield TL, Koppelhus U, Garred P (1998) Chemokine receptor CCR2b 641 polymorphism and its relation to CD4 T-cell counts and disease progression in a Danish cohort of HIV-infected individuals. Copenhagen AIDS cohort. J Acquir Immune Defic Syndr Hum Retrovirol 18: 110-116.
27. Gonzalez E, Bamshad M, Sato N, Mummidi S, Dhanda R, et al. (1999) Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci U S A 96: 12004-12009.
28. Schinkel J, Langendam, MW, Coutinho PA, Krol A, Brouwer M, et al. (1999) No evidence for an effect of the CCR5 delta32/+ and CCR2b 641/+ mutations on human ummunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. J Infect Dis 179: 825-831.
29. Mummidi S, Bamshad M, Ahuja SS, Gonzalez E, Feuillet PM, et al. (2000) Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus. J Biol Chem 275: 18946-18961.
30. Mangano A, Gonzalez E, Dhanda R, Catano, G, Bamshad M, et al. (2001) Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus. J Infect Dis 183: 157-1585.
31. Ometto L, Zanchetta M, Mainardi M, De Salvo GL, Garcia-Rodriguez MC, et al. (2000) Co-receptor usage of HIV-1 primary isolates, viral burden, and CCR5 genotype in mother-to-child HIV-1 transmission. Aids 14: 1721-1729.
32. Mwapasa V, Rogerson SJ, Kwiek JJ, Wilson PE, Milner D, et al. (2006) Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi. Aids 20: 1869-1877.
33. Mwapasa V, Rogerson SJ, Molyneux ME, Abrams ET, Kamwendo DD, et al. (2004) The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrationsin pregnant Malawian-women. Aids 18:1051-1059.
34. Salkowitz JR, Purvis SF, Meyerson H, Zimmerman P, O'Brien TR, et al. (2001) Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin Immunol 98: 200-211.
35. Bruse S, Blood M, Zimmerman P (2006) Multiplex Ligase Detection Reaction- based Genotyping Analysis of CCR2-CCR5 Polymorphism Improves Large-scale Population Studies of HIV Co-receptors.: Case Western Reserve University Rutgers University.
36. Heitgan DF (1997) Annotation: what can be done about missing data? Approaches to imputation. Am J Public Health 87: 548-550.
37. Little R, Rubin DB (1987) Statistical Analysis with Missing Data. New York: John Willey and Sons, Inc.
38. Rubin D (1987) Multiple Imputation for Nonresponse n Surveys. New York: John Wiley and Sons, Inc.
39. Thomas SM, Tse DB, Ketne, DS, Rochford G, Meyer DA, et al. (2006) CCR5 expression and duration of high risk sexual activity among HIV-scronegative men who have sex with men. Aids 20: 1879-1881
40. Kawamura T, Gulden FO, Sugaya M, McNamara DT, Borris DT, et al, (2003) R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms. Proc Natl Arad Sci U S A 100: 8401-8406.
41. John GC, Bird T, Overbaugh J, Nduati R, Mbori-Ngacha D, et al. (2001) CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort association with increased 2-year maternal mortality. J Infect Dis 184: 89-92.
42. Kwiek JJ, Mwapasa V, Milner DA Jr, Alker AP, Miller WC, et al. (2006) Materital-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi. PLoS Med 3: e10.
43. Lederman MM, Veazey RS, Offord R, Mosier DE, Dufour J, et al. (2004), Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306: 485-487.
44. Princen K, Schols D (2W5) HIV chemokine receptor inhibitors as novel anti-HIV drugs. Cytokine Growth Factor Rev 16: 659-677.