Doxycycline protects against pilocarpine-induced convulsions in rats, through its antioxidant effect and modulation of brain amino acids

Pharmacology Biochemistry and Behavior

Volumn 98, Issue 4, 2011, Pages 525-532

  Nogueira, Carlos Renato Alves ^a   Damasceno, Flávio Maia ^a   De Aquino Neto, Manuel Rufino ^a   De Andrade, Geanne Matos ^a   Fontenele, Juvênia Bezerra ^a   De Medeiros, Thales Augusto ^b   Viana, Glauce Socorro De Barros ^a,b,c  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b Faculty of Medicine of Juazeiro do Norte   (Brazil)

^c NONE   (Brazil)

Author keywords

Amino acid concentrations; Antioxidant activity; Doxycycline; Epilepsy; Neuroprotection; Pilocarpine induced convulsions

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; DOXYCYCLINE; GLUTAMIC ACID; GLYCINE; NITRITE; PILOCARPINE; TAURINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRYPTOPHAN; TYROSINE;

AKINESIA; AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATAXIA; AUTOMATISM; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; CONVULSION; DEATH; DIARRHEA; DOSE RESPONSE; DRUG MECHANISM; EXCITOTOXICITY; HIPPOCAMPUS; LATENT PERIOD; LICKING; LIPID PEROXIDATION; MALE; MIOSIS; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REARING; REFLEX; REPEATED DRUG DOSE; SALIVATION; SNIFFING; STAINING; TEMPORAL CORTEX; TREMOR;

AMINO ACIDS; ANIMALS; ANTIOXIDANTS; BRAIN; DOXYCYCLINE; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; NITRITES; PILOCARPINE; RATS; RATS, WISTAR; SEIZURES;

ANIMALIA; RATTUS;

EID: 79953066435     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.02.025     Document Type: Article

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