Rational design of β-sheet ligands against Aβ42- induced toxicity

Journal of the American Chemical Society

Volumn 133, Issue 12, 2011, Pages 4348-4358

  Hochdörffer, Katrin ^a   März Berberich, Julia ^a   Nagel Steger, Luitgard ^b   Epple, Matthias ^a   Meyer Zaika, Wolfgang ^a   Horn, Anselm H C ^c   Sticht, Heinrich ^c   Sinha, Sharmistha ^d   Bitan, Gal ^d,e   Schrader, Thomas ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION BEHAVIOR; ALZHEIMER'S; ANCHOR POINT; CELLULAR TOXICITIES; CHEMICAL GROUP; COMPLEX STRUCTURE; CYCLOHEXYL; DISAGGREGATION; DISPERSIVE INTERACTIONS; EXPERIMENTAL EVIDENCE; FLUORESCENCE CORRELATION SPECTROSCOPY; HIGH MOLECULAR WEIGHT; HYBRID LIGAND; MD SIMULATION; NON-POLAR; NON-TOXIC MATERIALS; PROTOFILAMENTS; RATIONAL DESIGN; SEDIMENTATION VELOCITIES; SPECIFIC INTERACTION; TEM; U-SHAPED;

AMINO ACIDS; BINDING SITES; CARBOXYLIC ACIDS; DYNAMIC LIGHT SCATTERING; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; OLIGOMERS; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

LIGANDS;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMINO ACID; AMINO ACID DERIVATIVE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; GLUTAMIC ACID; LEUCYLPROLYLPHENYLALANYLPHENYLALANYLASPARTIC ACID; LIGAND; LYSINE; THIOFLAVINE; TRIETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA SHEET; CELL ASSAY; CELL PROTECTION; CELL VIABILITY; CIRCULAR DICHROISM; COLLOID; CONTROLLED STUDY; CYTOTOXICITY; DYNAMIC LIGHT SCATTERING; FLUORESCENCE; FLUORESCENCE CORRELATION SPECTROSCOPY; LIGHT SCATTERING; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NERVE FIBER; NONHUMAN; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEDIMENTATION; SEDIMENTATION VELOCITY ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID BETA-PEPTIDES; BINDING SITES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953063528     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja107675n     Document Type: Article

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