Risky Alcohol Use in Adolescence: The Role of Genetics (DRD2, SLC6A4) and Coping Motives

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 4, 2011, Pages 756-764

  Van der Zwaluw, Carmen S ^a   Kuntsche, Emmanuel ^b   Engels, Rutger C M E ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b SWISS INSTITUTE FOR THE PREVENTION OF ALCOHOL AND DRUG PROBLEMS   (Switzerland)

Author keywords

Alcohol related Problems; Binge Drinking; Coping Motives; DRD2; SLC6A4

Indexed keywords

ALCOHOL; GENOMIC DNA;

ADOLESCENCE; ADOLESCENT; ALCOHOL CONSUMPTION; ARTICLE; BINGE DRINKING; COPING BEHAVIOR; CROSS-SECTIONAL STUDY; DRINKING BEHAVIOR; FEMALE; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUESTIONNAIRE;

ADAPTATION, PSYCHOLOGICAL; ADOLESCENT; ADOLESCENT BEHAVIOR; ALCOHOL DRINKING; ALCOHOL-RELATED DISORDERS; ALCOHOLISM; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MOTIVATION; RECEPTORS, DOPAMINE D2; RISK-TAKING; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STUDENTS;

EID: 79953052804     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01393.x     Document Type: Article

References (82)

1. Abbey A, Smith MJ, Scott RO (1993) The relationship between reasons for drinking alcohol and alcohol consumption: an interactional approach. Addict Behav 18:659-670.
2. Agrawal A, Dick DM, Bucholz KK, Madden PAF, Cooper ML, Sher KJ, Heath AC (2008) Drinking expectancies and motives: a genetic study of young adult women. Addiction 103:194-204.
3. Andersson B, Hibell B, Beck F, Choquet M, Kokkevi A, Fotiou A, Molinaro S, Nociar A, Sieroslawski J, Trapencieris M (2007) Alcohol and drug use among European 17-18year old students. Data from the ESPAD project. The Swedish Council for Information on Alcohol and Other Drugs (CAN) and the Pompidou Group at the Council of Europe. Modintryckoffset AB, Stockholm.
4. Armeli S, Conner TS, Covault J, Tennen H, Kranzler HR (2008) A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students. J Stud Alcohol Drugs 69:814-823.
5. Audrain-McGovern J, Rodriguez D, Wileyto P, Schmitz KH, Shields PG (2006) Effect of team sport participation on genetic predisposition to adolescent smoking progression. Arch Gen Psychiat 63:434-441.
6. Baer JS (2002) Student factors: understanding individual variation in college drinking. J Stud Alcohol 14(Suppl.):40-53.
7. Bau CHD, Almeida S, Hutz MH (2000) The Taq1 A1 allele of the dopamine D2 receptor gene and alcoholism in Brazil. Am J Med Genet 2000(96):302-306.
8. Beseler CL, Aharonovich E, Keyes KM, Hasin DS (2008) Adult transition from at-risk drinking to alcohol dependence: the relationship of family history and drinking motives. Alcohol Clin Exp Res 32:607-616.
9. Bierut LJ, Dinwiddie SH, Begleiter H, Crowe RR, Hesselbrock V, Nurnberger JI, Porjesz B, Schuckit MA, Reich T (1998) Familial transmission of substance dependence: alcohol, marihuana, cocaine, and habitual smoking. Arch Gen Psychiat 55:982-988.
10. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG, Coming DE (1996) The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J Roy Soc Med 89:396-400.
11. Burmeister M, McInnis MG, Zöllner S (2008) Psychiatric genetics: progress amid controversy. Nat Rev Genet 9:527-540.
12. Carey KB, Correia CJ (1997) Drinking motives predict alcohol-related problems in college students. J Stud Alcohol 58:100-105.
13. Chalder M, Elgar FJ, Bennett P (2006) Drinking and motivations to drink among adolescent children of parents with alcohol problems. Alcohol Alcohol 41:107-113.
14. Cloninger CR, Bohman M, Sigvardsson S (1981) Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiat 38:861-868.
15. Colder CR (2001) Life stress, physiological and subjective indexes of negative emotionality and coping reasons for drinking: is there evidence for a self-medication model of alcohol use? Psychol Addict Behav 15:237-245.
16. Conner BT, Noble EP, Berman SM, Ozkaragoz T, Ritchie T, Antolin T, Sheen C (2005) DRD2 genotypes and substance use in adolescent children of alcoholics. Drug Alcohol Depend 79:379-387.
17. Cooper ML (1994) Motivations for alcohol use among adolescents: development and validation of a four-factor model. Psychol Assessment 6:117-128.
18. Cooper ML, Frone MR, Russell M, Mudar P (1995) Drinking to regulate positive and negative emotions: a motivational model of alcohol use. J Pers Social Psychol 69:990-1005.
19. Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillesen AHN, Kranzler HR (2007) Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiat 61:609-616.
20. Cox WM, Klinger E (1988) A motivational model of alcohol use. J Abnorm Psychol 97:168-180.
21. Dick DM, Foroud T (2003) Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 27:868-879.
22. Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, Porjesz B, Begleiter H, Bierut LJ, Goate A (2007) Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res 31:1645-1653.
23. Enders CK (2001) The performance of the full information maximum likelihood estimator in multiple regression models with missing data. Educ Psychol Meas 61:713-740.
24. Engels RCME, Van derVorstH, Dekovic M, Meeus W (2007) Correspondence in collateral and self reports on alcohol consumption: a within family analysis. Addict Behav 32:1016-1030.
25. Feinn R, Nellissery M, Kranzler HR (2005) Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet 133B:79-84.
26. Foley PF, Low E-W, Innes DJ, Williams SM, Tannenberg AEG, Harper CG, Dodd PR (2004) Association studies of neurotransmitter gene polymorphism in alcohol Caucasians. Ann N Y Acad Sci 1025:39-46.
27. Gelernter J, Kranzler H, Cubells J (1997) Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101:243-246.
28. Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Gen 6:521-532.
29. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL (2000) Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96B:202-216.
30. Guo G, Wilhelmsen K, Hamilton N (2007) Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Am J Med Genet 144B:417-423.
31. Hallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynanen OP, Kauhanen J, Syvalahti E, Hietala J, Tiihonen J (1999) Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatr 4:385-388.
32. Ham LS, Hope DA (2003) College students and problematic drinking: a review of the literature. Clin Psychology Rev 23:719-759.
33. Harakeh Z, Scholte RHJ, De Vries H, Engels RCME (2005) Parental rules and communication: their association with adolescent smoking. Addiction 100:862-870.
34. Hariri A, Holmes A (2006) Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 10:182-191.
35. Hopfer CJ, Crowley TJ, Hewitt JK (2003) Review of twin and adoption studies of adolescent substance use. J Am Acad Child Adolesc Psychiatry 42:710-719.
36. Jaccard J, Turrisi R, Wan CK (1990) Interaction effects in multiple regression. Sage, Newbury Park, CA.
37. Kassel JD, Jackson SI, Unrod M (2000) Generalized expectancies for negative mood regulation and problem drinking among college students. J Stud Alcohol 61:332-340.
38. Kerr WC, Greenfield TK, Tujague J, Brown SE (2005) A drink is a drink? Variation in the amount of alcohol contained in beer, wine and spirits drinks in a US methodological sample. Alcohol Clin Exp Res 29:2015-2021.
39. Kuntsche E, Knibbe RA, Gmel G, Engels RCME (2005) Why do young people drink? A review of drinking motives. Clin Psychol Rev 25:841-861.
40. Kuntsche E, Knibbe RA, Gmel G, Engels RCME (2006) Who drinks and why? A review of socio-demographic, personality, and contextual issues behind the drinking motives in young people. Addict Behav 31:1844-1857.
41. Kuntsche E, Knibbe RA, Gmel G, Engels RCME (2007) Drinking motives as mediators of the link between alcohol expectancies and alcohol use among adolescents. J Stud Alcohol Drugs 68:76-85.
42. Kuntsche E, Steward SH, Cooper ML (2008) How stable is the motive-alcohol use link? A cross-validation of the Drinking Motives Questionnaire Revised among adolescents from Switzerland, Canada, and the United States. J Stud Alcohol Drugs 69:388-396.
43. Kuntsche E, Stewart SH (2009) Drinking motives of classroom peers as predictors of individual drinking motives and alcohol use in adolescence - A mediational model. J Health Psychol 14:530-540.
44. LeMarquand D, Phil RO, Benkelfat C (1994a) Serotonin and alcohol intake, abuse and dependence: clinical evidence. Biol Psychiat 36:326-337.
45. LeMarquand D, Phil RO, Benkelfat C (1994b) Serotonin and alcohol intake, abuse and dependence: findings of animal studies. Biol Psychiat, 36:395-421.
46. Lesch KP (2005) Alcohol dependence and gene x environment interaction in emotion regulation: is serotonin the link? Eur J Pharmacol 526:113-124.
47. Long JS, Freese J (2006) Regression models for categorical dependent variables using Stata, 2nd Edition. Stata Press, Texas.
48. Maisto SA, Carey KB, Bradizza CM (1999) Social learning theory, in Psychological Theories of Drinking and Alcoholism, 2nd edn (Leonard KE, Blane HT eds), pp 106-163. The Guilford Press, New York.
49. Merikangas KR, Stevens DE, Fenton B, Stolar M, O'Malley S, Woods SW, Risch N (1998) Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 28:773-788.
50. Moffitt TE (2005) The new look of behavioural genetics in developmental psychopathology: gene-environment interplay in antisocial behaviours. Psychol Bull 131:533-554.
51. Monshouwer K, Verdurmen J, Van DorsselaerS, Smit E, Gorter A, Vollebergh W (2008). Jeugd en riskant gedrag 2007: kerngegevens uit het peilsstationonderzoek scholieren [Youth and risk behavior 2007: data from research among pupils and students]. Trimbos Instituut, Utrecht.
52. Munafo MR, Johnstone EC, Welsh KI, Walton RT (2005) Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers. Pharmacogenomics J 5:96-101.
53. Munafo MR, Matheson IJ, Flint J (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatr 12:454-461.
54. Muthén LA, Muthén BO (1998-2006) Mplus user's guide, 4th edition. Muthén and Muthén, Los Angeles.
55. Naimi TS, Brewer RD, Mokdad A, Denny C, Serdula MK, Marks JS (2003) Binge drinking among U.S. adults. J Am Med Assoc 289:70-75.
56. Neville MJ, Johnstone EC, Walton RT (2004) Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 23:540-545.
57. Newlin DB, Miles DR, Van den Bree MB, Gupman AE, Pickens RW (2000) Environmental transmission of DSM-IV substance use disorders in adoptive and stepfamilies. Alcohol Clin Exp Res 24:1785-1794.
58. Nilsson KW, Sjöberg RL, Damberg M, Alm P, Öhrvik J, Leppert J, Lindström L, Oreland L (2005) Role of serotonin transporter gene and family function in adolescent alcohol consumption. Alcohol Clin Exp Res 29:564-570.
59. Noble EP (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet 116B:103-125.
60. Noble EP, Blum J, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiat 48:648-654.
61. Olsson CA, Byrnes GB, Lotfi-Miri M, Collins V, Williamson R, Patton C, Anney RJL (2005) Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results for a 10-year longitudinal study of adolescent mental health. Mol Psychiatr 10:868-876.
62. Pagan JL, Rose RJ, Viken RJ, Pulkkinen L, Kaprio J, Dick DM (2006) Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. Behav Genet 36:483-497.
63. Pohlainen T, Rinne JO, Nagren K, Lehikoinen P, Anttila K, Syvalahti EK, Hietala J (1998) The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatr 3:256-260.
64. Ponce G, Hoenicka J, Jiménez-Arriero MA, Rodríguez-Jiménez R, Aragüés M, Martín-Suñé N, Huertas E, Palomo T (2008) DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Brit J Psychiat 193:121-125.
65. Prescott CA, Cross RJ, Kuhn JW, Horn JL, Kendler KS (2004) Is risk for alcoholism mediated by individual differences in drinking motivations? Alcohol Clin Exp Res 28:29-39.
66. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population based sample of male twins. Am J Psychiatry 156:34-40.
67. Raymond M, Rousset F (1995) GENEPOP (Version 1.2) Population genetics software for exact tests and ecumenicism. J Hered 86:248-249.
68. Riley BP (2008) Commentary on 'The case for gene-environment interactions in psychiatry'. Curr Opin Psychiatry 21:324-325.
69. Schinka JA, Busch RM, Robichaux-Keene N (2004) A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatr 9:197-202.
70. Skowronek MH, Laucht M, Hohm E, Becker K, Schmidt MH (2006) Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics 7:239-246.
71. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Ferrier IN, Court JA (1997) D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7:479-484.
72. Van der Vorst H, Engels RCME, Meeus W, Dekovic M, Van Leeuwe J (2005) The role of alcohol-specific socialization in adolescents' drinking behavior. Addiction 100:1464-1476.
73. Van der Zwaluw CS, Engels RCME (2009) Gene-environment interactions and alcohol use and dependence: current status and future challenges. Addiction 104:907-914.
74. Van der Zwaluw CS, Engels RCME, Vermulst AA, Franke B, Buitelaar J, Verkes RJ, Scholte RHJ (2010) Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction. Mol Psychiatr 15:727-735.
75. Verster JC, van DuinD, Volkerts ER, Schreuder AH, Verbaten MN (2003) Alcohol hangover effects on memory functioning and vigilance performance after an evening of binge drinking. Neuropsychopharmacology 28:740-746.
76. Viken RJ, Kaprio J, Koskenvuo M, Rose RJ (1999) Longitudinal analyses of the determinants of drinking and of drinking to intoxication in adolescent twins. Behav Genet 29:455-461.
77. Virkkunen M, Linnoila M (1997) Serotonin in early-onset alcoholism. Rec Dev Alcohol 13:173-189.
78. Wechsler H, Nelson TF (2001) Binge drinking and the American college student: what's five drinks? Psychol Addict Behav 15:287-291.
79. White HR, Labouvie EW (2000) Longitudinal trends in problem drinking as measured by the Rutgers Alcohol Problem Index. Paper presented at the 23rd Annual Scientific Meeting of the Research Society on Alcoholism. Denver, CO.
80. Windle M, Windle RC (1996) Coping strategies, drinking motives, and stressful life events among middle adolescents: associations with emotional behavioral problems and with academic functioning. J Abnorm Psychol 105:551-560.
81. Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2007) Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case-control and family samples. Hum Mol Genet 16:2844-2853.
82. Young RM, Lawford BR, Nutting A, Noble EP (2004) Advances in molecular genetics and the prevention and treatment of substance misuse: implications of association studies of the A1 allele of the D2 dopamine receptor gene. Addict Behav 29:1275-1294.