A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students

Journal of Studies on Alcohol and Drugs

Volumn 69, Issue 6, 2008, Pages 814-823

  Armeli, Stephen ^a,b   Conner, Tamlin S ^a,b   Covault, Jonathan ^a   Tennen, Howard ^a   Kranzler, Henry R ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b FAIRLEIGH DICKINSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; COLLEGE STUDENT; CONTROLLED STUDY; DRINKING BEHAVIOR; DRINKING TO COPE MOTIVATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEALTH SURVEY; HUMAN; INTERNET; LIFE EVENT; MALE; SEX DIFFERENCE; STRESS; SUBSTANCE ABUSE;

EID: 57549083057     PISSN: 19371888     EISSN: 19384114     Source Type: Journal    
DOI: 10.15288/jsad.2008.69.814     Document Type: Article

References (58)

1. ARMELI, S., TODD, M., AND MOHR, C. A daily process approach to individual differences in stress-related alcohol use. J. Pers. 73: 1657-1686, 2005.
2. BANDURA, A. Social learning of moral judgments. J. Pers. Social Psychol. 11: 275-279, 1969.
3. BARNOW, S., SCHUCKIT, M.A., LUCHT, M., JOHN, U., AND FREYBERGER, H.J. The importance of a positive family history of alcoholism, parental rejection and emotional warmth, behavioral problems and peer substance use for alcohol problems in teenagers: A path analysis. J. Stud. Alcohol 63: 305-315, 2002.
4. BRADLEY, S.L., DODELZON, K., SANDHU, H.K., AND PHILIBERT, R.A. Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. Amer. J. Med. Genet. Part B: Neuropsychiat. Genet. 136: 58-61, 2005.
5. CADORET, R.J., LANGBEHN, D., CASPERS, K., TROUGHTON, E.P., YUCUIS, R., SANDHU, H.K., AND PHILIBERT, R. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprhen. Psychiat. 44: 88-101, 2003.
6. CASPI, A., SUGDEN, K., MOFFITT, T.E., TAYLOR, A., CRAIG, I.W, HARRINGTON, H., MCCLAY, J., MILL, J., MARTIN, J., BRAITHWAITE, A., AND POULTON, R. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389, 2003.
7. COLDER, C.R. Life stress, physiological and subjective indexes of negative emotionality, and coping reasons for drinking: Is there evidence for a self-medication model of alcohol use? Psychol. Addict. Behav. 15: 237-245, 2001.
8. COOPER, M.L. Motivations for alcohol use among adolescents: Development and validation of a four-factor model. Psychol. Assess. 6: 117-128, 1994.
9. COOPER, M.L., FRONE, M.R., RUSSELL, M., AND MUDAR, P. Drinking to regulate positive and negative emotions: A motivational model of alcohol use. J. Pers. Social Psychol. 69: 990-1005, 1995.
10. COVAULT, J., TENNEN, H., HERMAN, A.I., ARMELI, S., CONNER, T.S., CILLESSEN, A.H.N., AND KRANZLER, H.R. Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol. Psychiat. 61: 609-616, 2007.
11. COX, W.M. AND KLINGER, E. A motivational model of alcohol use. J. Abnorm. Psychol. 97: 168-180, 1988.
12. DICK, D.M. AND FOROUD, T. Candidate genes for alcohol dependence: A review of genetic evidence from human studies. Alcsm Clin. Exp. Res. 27: 868-879, 2003.
13. DICK, D.M., PLUNKETT, J., HAMLIN, D., NURNBERGER, J., JR., KUPERMAN, S., SCHUCKIT, M., HESSELBROCK, V., EDENBERG, H., AND BIERUT, L. Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Psychiat. Genet. 17: 35-38, 2007.
14. ELEY, T.C., SUGDEN, K., CORSICO, A., GREGORY, A.M., SHAM, P., MCGUFFIN, P., PLOMIN, R., AND CRAIG, I.W. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol. Psychiat. 9: 908-915, 2004.
15. FEINN, R., NELLISSERY, M., AND KRANZLER, H.R. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Amer. J. Med. Genet. Part B: Neuropsychiat. Genet. 133: 79-84, 2005.
16. FINGER, E.C., MARSH, A.A., BUZAS, B., KAMEL, N., RHODES, R., VYTHILINGHAM, M., PINE, D.S., GOLDMAN, D., AND BLAIR, J.R. The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks. Neuropsychopharmacology 32: 206-215, 2007.
17. GERRA, G., GAROFANO, L., SANTORO, G., BOSARI, S., PELLEGRINI, C., ZAIMOVIC, A., MOI, G., BUSSANDRI, M., MOI, A., BRAMBILLA, F., AND DONNINI, C. Association between low-activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates. Amer. J. Med. Genet. Part B. Neuropsychiat. Genet. 126: 37-42, 2004.
18. GRABE, H.J., LANGE, M., WOLFF, B., VÖLZKE, H., LUCHT, M., FREYBERGER, H.J., JOHN, U., AND CASCORBI, I. Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol. Psychiat. 10: 220-224, 2005.
19. GREELEY, J. AND OEI, T. Alcohol and tension reduction. In: [s LEONARD, K.E. AND BLANE, H.T. (Eds.) Psychological Theories of Drinking and Alcoholism, 2nd Edition, NewYork: Guilford Press, 1999, pp. 14-53.
20. GREENBERG, B.D., TOLLIVER, T.J., HUANG, S.J., LI, Q., BENGEL, D., AND MURPHY, D.L. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Amer. J. Med. Genet. Part B: Neuropsychiat. Genet. 88: 83-87, 1999.
21. HERMAN, A.I., PHILBECK, J.W., VASILOPOULOS, N.L., AND DEPETRILLO, P.B. Serotonin transporter promoter polymorphism and differences in alcohol consumption behavior in a college student population. Alcohol Alcsm 38: 446-449, 2003.
22. HINKERS, A.S., LAUCHT, M., SCHMIDT, M.H., MANN, K.F., SCHUMANN, G., SCHUKIT, M.A., AND HEINZ, A. Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. Biol. Psychiat. 60: 282-287, 2006.
23. HU, X.Z., LIPSKY, R.H., ZHU, G., AKHTAR, L.A., TAUBMAN, J., GREENBERG, B.D., XU, K., ARNOLD, P.D., RICHTER, M.A., KENNEDY, J.L., MURPHY, D.L., AND GOLDMAN, D. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Amer. J. Human Genet. 78: 815-826, 2006.
24. HU, X., OROSZI, G., CHUN, J., SMITH, T.L., GOLDMAN, D., AND SCHUCKIT, M.A. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcsm Clin. Exp. Res. 29: 8-16, 2005.
25. KAUFMAN, J., YANG, B.-Z., DOUGLAS-PALUMBER, H., CROUSE-ARTUS, M., LIPSCHITZ, D., KRYSTAL, J., AND GELERNTER, J. Genetic and environmental predictors of early alcohol use. Biol. Psychiat. 61: 1228-1234, 2007.
26. LESCH, K.P., BENGEL, D., HEILS, A., SABOL, S.Z., GREENBERG, B.D., PETRI, S., BENJAMIN, J., MULLER, C.R., HAMER, D.H., AND MURPHY, D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531, 1996.
27. LINDEN, W. Development and initial validation of a life event scale for students. Can. Couns. 18: 106-110, 1984.
28. MAISTO S.A., CAREY, K.B., AND BRADIZZA, C.M. Social learning theory. In: LEONARD, K.E. AND BLANE, H.T. (Eds.) Psychological Theories of Drinking and Alcoholism, 2nd Edition, New York: Guilford Press, 1999, pp. 106-163.
29. MANN J.J. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 21 (Suppl. No. 1): 99S-105S, 1999.
30. MITCHELL, P.B., WILHELM, K., AND PARKER, G. Interaction between life events and 5-HTT genotype in determining the likelihood of depression and anxiety in a 25-year longitudinal study of Australian teachers (abstract). Amer. J. Med. Genet. Part B: Neuropsychiat. Genet. 130: 36, 2004.
31. MORENO, F.A., ROWE, D.C., KAISER, B., CHASE, D., MICHAELS, T., GELERNTER, J., AND DELGADO, P.L. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol. Psychiat. 7: 213-216, 2002.
32. MUNAFÒ, M.R., LINGFORD-HUGHES, A.R., JOHNSTONE, E.C., AND WALTON, R.T. Association between the serotonin transporter gene and alcohol consumption in social drinkers. Amer. J. Med. Genet. Part B: Neuropsychiat. Genet. 135: 10-14, 2005.
33. NEIGHBORS, C., LEE, C.M., LEWIS, M.A., FOSSOS, N., AND LARIMER, M.E. Are social norms the best predictor of outcomes among heavy drinking college students? J. Stud. Alcohol Drugs 68: 556-565, 2007.
34. NEUMEISTER, A., HU, X.-Z., LUCKENBAUGH, D.A., SCHWARZ, M., NUGENT, A.C., BONNE, O., HERSCOVITCH, P., GOLDMAN, D., DREVETS, W.C., AND CHARNEY, D.S. Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch. Gen. Psychiat. 63: 978-986, 2006.
35. NEUMEISTER, A., KONSTANTINIDIS, A., STASTNY, J., SCHWARZ, M.J., VITOUCH, O., WILLEIT, M., PRASCHAK-RIEDER, N., ZACH, J., DE ZWAAN, M., BONDY, B., ACKENHEIL, M., AND KASPER, S. Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch. Gen. Psychiat. 59: 613-620, 2002.
36. NILSSON, K.W., SJÖBERG, R.L., DAMBERG, M., ALM, P.O., ÖHRVIK, J., LEPPERT, J., LINDSTRÖM, L., AND ORELAND, L. Role of the serotonin transporter gene and family function in adolescent alcohol consumption. Alcsm Clin. Exp. Res. 29: 564-570, 2005.
37. O'MALLEY P.M. AND JOHNSTON L.D. Epidemiology of alcohol and other drug use among American college students. J. Stud. Alcohol, Supplement No. 14, pp. 23-39, 2002.
38. OOTEMAN, W., KOETER, M., VERHEUL, R., SCHIPPERS, G., AND VAN DEN BRINK, W. Development and validation of the Amsterdam Motives for Drinking Scale (AMDS): An attempt to distinguish reward and relief drinkers. Alcohol Alcsm 41: 284-292, 2006.
39. OQUENDO, M.A., HASTINGS, R.S., HUANG, Y.-Y., SIMPSON, N., OGDEN, R.T., HU, X.-Z., GOLDMAN, D., ARANGO, V., VAN HEERTUM, R.L., MANN, J.J., AND PARSEY, R.V. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch. Gen. Psychiat. 64: 201-208, 2007.
40. PARSEY, R.V., HASTINGS, R.S., OQUENDO, M.A., HU, X., GOLDMAN, D., HUANG, Y.-Y., SIMPSON, N., ARCEMENT, J., HUANG, Y., OGDEN, R.T., VAN HEERTUM, R.L., ARANGO, V., AND MANN, J.J. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Amer. J. Psychiat. 163: 48-51, 2006.
41. PEZAWAS, L., MEYER-LINDENBERG, A., DRABANT, E.M., VERCHINSKI, B.A., MUNOZ, K.E., KOLACHANA, B.S., EGAN, M.F., MATTAY, V.S., HARIRI, A.R., AND WEINBERGER, D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neurosci. 8: 828-834, 2005.
42. PIERUCCI-LAGHA, A., FEINN, R., MODESTO-LOWE, V., SWIFT, R., NELLISSERY, M. COVAULT, J., AND KRANZLER, H.R. Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacol. 171: 340-348, 2004.
43. 11C] DASB positron emission tomography study. Biol. Psychiat. 62: 327-331, 2007.
44. RAUDENBUSH, S.W. AND BRYK, A.S. Hierarchical Linear Models: Applications and Data Analysis Methods, 2nd Edition, Thousand Oaks, CA: Sage, 2002.
45. RAUDENBUSH, S., BRYK, A., CHEONG, Y.F., CONGDON, R., AND DU TOIT, M. HLM 6: Hierarchical Linear and Nonlinear Modeling, Lincolnwood, IL: Scientific Software International, 2004.
46. READ, J.P., WOOD, M.D., KAHLER, C.W., MADDOCK, J.E., AND PALFAI, T.P. Examining the role of drinking motives in college student alcohol use and problems. Psychol. Addict. Behav. 17: 13-23, 2003.
47. 11C]DASB is affected by serotonin transporter genotype. J. Neural Transmiss. 114: 635-639, 2007.
48. SARTOR, C.E., LYNSKEY, M.T., HEATH, A.C., JACOB, T., AND TRUE, W. The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction 102: 216-225, 2007.
49. SCHUCKIT, M.A., SMITH, T.L., ANDERSON, K.G., AND BROWN, S.A. Testing the level of response to alcohol: Social information processing model of alcoholism risk - A 20-year prospective study. Alcsm Clin. Exp. Res. 28: 1881-1889, 2004.
50. SIMONS, J., GAHER, R.M., CORREIA, C.J., HANSEN, C.L., AND CHRISTOPHER, M.S. An affective-motivational model of marijuana and alcohol problems among college students. Psychol. Addict. Behav. 19: 326-334, 2005.
51. SKOWRONEK, M.H., LAUCHT, M., HOHM, E., BECKER, K., AND SCHMIDT, M.H. Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics 7: 239-246, 2006.
52. SNIJDERS, T.A.B. AND BOSKER, R.J. Multilevel Analysis: An Introduction to Basic and Advanced Multilevel Modeling, Thousand Oaks, CA: Sage, 1999.
53. STACY, A.W., NEWCOMB, M.D., AND BENTLER, P.M. Cognitive motivation and problem drug use: A 9 year longitudinal study. J. Abnorm. Psychol. 100: 502-515, 1991.
54. 3H-] paroxetine binding in bulimic syndromes. Int. J. Eat. Disord. 37: 57-60, 2005.
55. SUBSTANCE ABUSE AND MENTAL HEALTH SERVICES ADMINISTRATION (Office of Applied Studies). Results from the 2003 National Survey on Drug Use and Health: National Findings, DHHS Publication No. (SMA) 043964, Rockville, MD: Substance Abuse and Mental Health Services Administration, 2004.
56. TAYLOR, S.E., WAY, B.M., WELCH, W.T., HILMERT, C.J., LEHMAN, B., AND EISENBERGER, N.I. Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol. Psychiat. 60: 671-676, 2006.
57. WALDERHAUG, E., MAGNUSSON, A., NEUMEISTER, A., LAPPALAINEN, J., LUNDE, H., REFSUM, H., AND LANDRO, N.I. Interaction effects of sex and 5HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol. Psychiat. 62: 593-599, 2007.
58. WILLS, T.A. AND SHIFFMAN, S. Coping and substance use: A conceptual framework. In: SHIFFMAN, S. AND WILLS, T.A. (Eds.) Coping and Substance Abuse, San Diego, CA: Academic Press, 1985, pp 3-24.