Blockade of receptor-activated Gi signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation

Journal of Bone and Mineral Research

Volumn 26, Issue 4, 2011, Pages 822-832

  Millard, Susan M ^a   Louie, Alyssa M ^a   Wattanachanya, Lalita ^a,b   Wronski, Thomas J ^c   Conklin, Bruce R ^d,e   Nissenson, Robert A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c UNIVERSITY OF FLORIDA   (United States)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

G protein coupled receptors; Gi signaling; inbred mice; Osteoblasts; periosteal bone formation; sexual dimorphism

Indexed keywords

CALCEIN; COLLAGEN; DEMECLOCYCLINE; G PROTEIN COUPLED RECEPTOR; PERTUSSIS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; CANCELLOUS BONE; CELL FUNCTION; CONTROLLED STUDY; CORTICAL BONE; FEMALE; IN VIVO STUDY; MALE; MINERALIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PERIOSTEUM; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEPTOR BLOCKING; REGULATORY MECHANISM; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TRANSGENE;

AGE FACTORS; ANIMALS; BODY WEIGHT; CALCIFICATION, PHYSIOLOGIC; COLLAGEN TYPE I; CYCLINS; DOXYCYCLINE; FEMALE; FEMUR; FIBRILLAR COLLAGENS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPROTEGERIN; PEPTIDE FRAGMENTS; PEPTIDES; PERTUSSIS TOXIN; PROCOLLAGEN; PROMOTER REGIONS, GENETIC; RANK LIGAND; RECEPTORS, CALCITONIN; RECEPTORS, G-PROTEIN-COUPLED; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; X-RAY MICROTOMOGRAPHY;

EID: 79953044649     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.273     Document Type: Article

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