Assessment of tryptophol genotoxicity in four cell lines in vitro: A pilot study with alkaline comet assay

Arhiv za Higijenu Rada i Toksikologiju

Volumn 62, Issue 1, 2011, Pages 41-49

  Kosalec, Ivan ^a   Ramić, Snježana ^b   Jelić, Dubravko ^c   Antolović, Roberto ^d   Pepeljnjak, Stjepan ^a   Kopjar, Nevenka ^e  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF RIJEKA   (Croatia)

^e INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

Author keywords

aromatic alcohol; Candida albicans; DNA damage; permanent cell lines; secondary metabolite

Indexed keywords

TRYPTOPHOL;

ANIMAL CELL; ARTICLE; CANDIDA ALBICANS; CELL LINE; CELL METABOLISM; CELL STRAIN HEPG2; CELL TYPE; CHO CELL; COMET ASSAY; DECOMPOSITION; DNA DAMAGE; GENOTOXICITY; HOST; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; LIVER CELL; LUNG ALVEOLUS EPITHELIUM; MONOCYTE; MYCOSIS; NONHUMAN; OVARY CELL; PILOT STUDY; SPECIES; VAGINA EPITHELIUM;

ANIMALS; CANDIDA ALBICANS; CELL LINE; COMET ASSAY; DNA DAMAGE; HUMANS; INDOLES; MUTAGENICITY TESTS; PILOT PROJECTS;

ANIMALIA; CANDIDA; CANDIDA ALBICANS; FUNGI; LONCHOCARPUS GLAUCIFOLIUS;

EID: 79953041324     PISSN: 00041254     EISSN: None     Source Type: Journal    
DOI: 10.2478/10004-1254-62-2011-2090     Document Type: Article

References (52)

1. Dufour N, Rao RP. Secondary metabolites and other small molecules as intercellular pathogenic signals. FEMS Microbiol Lett 2011;314:10-7.
2. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 2001;67:2982-92. (Pubitemid 33644762)
3. Chen H, Fujita M, Feng Q, Clardy J, Fink GR. Tyrosol is a quorum sensing molecule in Candida albicans. Proc Natl Acad Sci USA 2004;101:5048-52. (Pubitemid 38469200)
4. Chen H, Fink GR. Feedback control of morphogenesis in fungi by aromatic alcohols. Genes Dev 2006;20:1150-61.
5. Enjalbert B, Whiteway M. Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. Eukaryot Cell 2005;4:1203-10. (Pubitemid 41004133)
6. Lo H-J, Köhler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C albicans mutants are avirulent. Cell 1997;90:939-49. (Pubitemid 27381632)
7. Ghosh S, Kebaara BW, Atkin AL, Nickerson KW. Regulation of aromatic alcohol production in Candida albicans. Appl Environ Microbiol 2008;74:7211-8. (Pubitemid 352773579)
8. Ernst JF. Transcription factors in Candida albicans environmental control of morphogenesis. Microbiology 2000;146:1763-74.
9. Martins M, Henriques M, Azeredo J, Rocha SM, Coimbra MA, Oliveira R. Morphogenesis control in Candida albicans and Candida dubliniensis through signaling molecules produced by planktonic and biofilm cells. Eukaryot Cell 2007;6:2429-36.
10. Oh K-B, Miyazawa H, Naito T, Matsuoka H. Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans. Proc Natl Acad Sci USA 2001;98:4664-8. (Pubitemid 32295033)
11. Shchepin R, Hornby JM, Burger E, Niessen T, Dussault P, Nickerson KW. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. Chem Biol 2003;10:743-50. (Pubitemid 37089849)
12. Lingappa BT, Prasad M, Lingappa Y, Hunt DF, Biemann K. Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans. Science 1969;163:192-4.
13. Sugawara F, Strobel GA. Tryptophol a phytotoxin produced by Drechslera nodulosum. Phytochemistry 1987;26: 1349-51.
14. Kosalec I, Pepeljnjak S, Delaforge M, Puel O, Galtier P. Possible toxicity of clinical isoates of Candida albicans. In: Balenovi M, editor. Proceedings of the Third Croatian Congress of Microbiology with International Participation; 4-7 Oct 2004. Pore, Croatia. Zagreb: Hrvatsko mikrobiološko društvo; 2004. p. 115-6.
15. Laan G, Magnus V, Šimaga Š, Iskri S, Hall PJ. Metabolism of tryptophol in higher and lower plants. Plant Physiol 1985;78:447-54.
16. Seed JR, Sechelski J. Tryptophol levels in mice injected with pharmacological doses of tryptophol, and the effect of pyrazole and ethanol on these levels. Life Sci 1977;21: 1603-10. (Pubitemid 9038718)
17. Cornford EM, Crane PD, Braun LD, Bocash WD, Nyerges AM, Oldendorf WH. Reduction in brain glucose utilization rate after tryptophol (3-indole ethanol) treatment. J Neurochem 1981;36:1758-65. (Pubitemid 11083549)
18. Koster RL, Grekoff JK. The physiological, hemolytic and immunosuppressive effects of possible trypanosomal metabolites in white mice. Bios 1981;52:227-36.
19. Tanaka K, McConnell B, Niemezura WP, Mower HF. Characterization and mutagenicity of 1-nitrosotryptophol and 6-nitrotryptophol possible genotoxic substances associated with smoking and alcohol consumption. Cancer Lett 1989;44:109-16. (Pubitemid 19063175)
20. Inagaki S, Morimura S, Shigematsu T, Kida K, Akutagawa H Apoptosis induction by vinegar produced from boiled extract of black soybeans in human monoblastic leukemia U937 cells: Difference in sensitivity to cell toxicity compared to normal lymphocytes. Food Sci Technol Res 2005;11: 311-7. (Pubitemid 44824956)
21. Inagaki S, Morimura S, Gondo K, Tang Y, Akutagawa H Kida K. Isolation of tryptophol as an apoptosis-inducing component of vinegar produced brom boiled extract of black soybean in human monoblastic leukemia U937 cells. Biosci Biotechnol Biochem 2007;71:371-9.
22. Inagaki S, Morimura S, Tang Y Akutagawa H, Kida K. Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells. Biosci Biotechnol Biochem 2007;71:2065-8. (Pubitemid 350113157)
23. Kosalec I, Šafrani A, Pepeljnjak S, Baun-Družina V, Rami S, Kopjar N. Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro. Basic Clin Pharmacol Toxicol 2008;102:443-52. (Pubitemid 351537786)
24. Kosalec I. Toksinogenost i mehanizmi djelovanja virulentnih?imbenika Candida vrsta [Toxicogenicity and mechanisms of action of virulence factors of Candida species] [PhD thesis]. Zagreb: Faculty of Pharmacy and Biochemistry, University of Zagreb; 2006.
25. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.
26. Poli P, Buschini A, Spaggiari A, Rizzoli V, Carlo-Stella C Rossi C DNA damage by tobacco smoke and some antiblastic drugs evaluated using the comet assay. Toxicol Lett 1999;108:267-76. (Pubitemid 29460794)
27. Chi-Square, Cramer's V, and Lambda [displayed 20 January 2011]. Available at http://facultyvassar.edu/lowry/newcs.html.
28. Mitchemmore CL, Chipman JK. DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring. Mutat Res 1998;399:135-47. (Pubitemid 28289318)
29. Tice RR, Agurell E, Anderson D. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35:206-21. (Pubitemid 30196665)
30. Salopek-Sondi B, Piljac-Žegarac J, Magnus V, Kopjar N. Free radical scavenging activity and DNA damaging potential of auxins IAA and 2-Methyl-IAA evaluated in human neutrophils by the alkaline comet assay J Biochem Mol Toxicol 2010;24:165-73.
31. Kosalec I, Puel O, Delaforge M, Kopjar N, Antolovi R, Jeli D, Matica B, Galtier P, Pepeljnjak S. Isolation and cytotoxicity of low-molecular-weight metabolites of Candida albican s. Front Biosci 2008;13:6893-904.
32. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 1997;77:517-44. (Pubitemid 27184347)
33. Ni R, Leo MA, Zhao J, Lieber CS. Toxicity of β-carotene and its exacerbation by acetaldehyde in HepG2 cells. Alcohol Alcohol 2001;36:281-5. (Pubitemid 32655222)
34. Meurman JH, Uittamo J. Oral micro-organisms in the etiology of cancer. Acta Odontol Scand 2008;66:321-6.
35. Darroudi F, Natarajan AT. Metabolic activation of chemicals to mutagenic carcinogens by human hepatoma microsomal extracts in Chinese hamster ovary cells (in vitro). Mutagenesis 1993;8:11-5. (Pubitemid 23060240)
36. Knasmüller S, Parzefall W, Sanyal R, Ecker S, Schwab C Uhl M, Mersch-Sundermann V, Williamson G, Hietsch G, Langer T, Darroudi F, Natarajan AT. Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat Res 1998;402:185-202. (Pubitemid 28440274)
37. Uhl M, Helma C, Knasmüller S. Evaluation of the single cell gel electrophoresis assay with human hepatoma (HepG2) cells. Mutat Res 2000;468:213-25. (Pubitemid 30406859)
38. Majer BJ, Mersch-Sundermann V, Darroudi F, Laky B, de Wit K, Knasmüller S. Genotoxic effects of dietary and lifestyle related carcinogens in human derived hepatoma (HepG2, Hep3B) cells. Mutat Res 2004;551:153-66. (Pubitemid 38833505)
39. Badawy AAB, Evans M. Alcohol and tryptophan metabolism. Alcohol Alcohol 1974;9:97-115.
40. Cornford EM, Bocash WD, Braun LD, Crane PD, Oldendorf WH. Rapid distribution of tryptophol (3-indole ethanol) to the brain and other tissues. J Clin Invest 1979;63:1241-8. (Pubitemid 9193220)
41. Foster KA, Oster CG, Mayer MM, Avery ML, Audus KL. Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 1998;243:359-66. (Pubitemid 28488846)
42. Carmichael J, Mitchell JB, Friedman N, Gazdar AF, Russo A. Glutathione and related enzyme activity in human lung cancer cell lines. Br J Cancer 1988;58:437-40. (Pubitemid 18267795)
43. Speit G, Bonzheim I. Genotoxic and protective effects of hyperbaric oxygen in A549 lung cells. Mutagenesis 2003;18:545-8. (Pubitemid 37461557)
44. Chipinda I, Ruwona TB, Templeton SP, Siegel PD. Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers. Toxicology 2011;280:135-43. DOI:10.1016/j.tox.2010.12.004.
45. Baird SK, Reid L, Hampton MB, Gieseg SP. OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochim Biophys Acta 2005;1745:361-9. (Pubitemid 41330789)
46. Roggen E, Aufderheide M, Cetin Y, Dearman RJ, Gibbs S, Hermanns I, Kimber I, Regal JF, Rovida C, Warheit DB, Uhlig S, Casati S. The development of novel approaches to the identification of chemical and protein respiratory allergens. Altern Lab Anim 2008;36:591-8.
47. Heyes MP, Chen CY, Major EO, Saito K. Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Biochem J 1997;326:351-6. (Pubitemid 27417209)
48. Weiss SJ, LoBuglio AF, Kessler HB. Oxidative mechanisms of monocyte-mediated cytotoxicity. Proc Natl Acad Sci USA 1980;77:584-7. (Pubitemid 10141066)
49. Nakazato T, Sagawa M, Yamato K, Xian M, Yamamoto T Suematsu M, Ikeda Y Kizaki M. Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells. Clin Cancer Res 2007;13:5436-45. (Pubitemid 47510371)
50. Byun J, Mueller DM, Fabjan JS, Heinecke JW. Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. FEBS Lett 1999;455:243-6. (Pubitemid 29333044)
51. Douglas LJ. Candida biofilms and their role in infection. Trends Microbiol 2003;11:30-6. (Pubitemid 36084353)
52. Mavor AL, Thewes S, Hube B. Systemic fungal infections caused by Candida species: Epidemiology, infection process and virulence attributes. Curr Drug Targets 2005;6:863-74. (Pubitemid 41672448)