Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives

Planta Medica

Volumn 75, Issue 14, 2009, Pages 1520-1522

  Theoduloz, Cristina ^a   Rodríguez, Jaime A ^a   Pertino, Mariano ^a   Schmeda Hirschmann, Guillermo ^a  

^a UNIVERSIDAD DE TALCA   (Chile)

Author keywords

Antiproliferative activity; Cancer cell lines; Euphorbiaceae; Jatropha isabelli; Jatropholone erivatives; Jatrophone; Semi synthesis

Indexed keywords

13ALPHA HYDROXY 9BETA ACETOXYISABELLIONE; 9BETA, 13ALPHA DIHYDROXYISABELLIONE; DITERPENE; HERBACEOUS AGENT; JATROPHOLONE A; JATROPHOLONE B; JATROPHONE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CARCINOMA; CANCER CELL CULTURE; DRUG ACETYLATION; DRUG ACTIVITY; DRUG INACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; JATROPHA; LEUKEMIA; LUNG CANCER; LUNG FIBROBLAST; NONHUMAN; STOMACH ADENOCARCINOMA; TUMOR CELL LINE;

ACETYLATION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; HUMANS; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS;

EUPHORBIACEAE; JATROPHA;

EID: 73349110047     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185834     Document Type: Article

References (8)

1. Kupchan S M., Sigel C W., Matz M J., Gilmore C J., Bryan R F. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. J Am Chem Soc 1976 98 2295-2300
2. Taylor M D., Smith III AB, Furst G T., Gunasekara S P., Bevelle C A., Cordell G A., Farnsworth N R., Kupchan S M., Uchida H, Branford A R., Dailey R G. Jr, Sneden A T. New antileukemic jatrophone derivatives from Jatropha gosypiifolia: structural and stereochemical assignment through nuclear magnetic resonance spectroscopy. J Am Chem Soc 1983 105 3177-3183
3. Taylor M D., Smith III A B., Malamas M S. Jatrophone, jatrophone derivatives, and analogues. Conformation and reactions with propanethiol. J Org Chem 1983 48 4257-4261
4. Pertino M, Schmeda-Hirschmann G, Rodríguez J A., Theoduloz C. Gastroprotective effect and cytotoxicity of diterpenes from the Paraguayan crude drug yagua rova (Jatropha isabelii). J Ethnopharmacol 2007 111 553-559
5. Pertino M, Schmeda-Hirschmann G, Rodríguez J A., Theoduloz C. Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives. Planta Med 2007 73 1095-1100 (Pubitemid 47401295)
6. Pertino M, Schmeda-Hirschmann G, Santos L S., Rodriguez J A., Theoduloz C. Biotransformation of jatrophone by Aspergillus niger ATCC 16404. Z Naturforsch B 2007 62 275-279
7. Bahmanyar S, Ye W, Dickman P W., Nyren O. Long-term risk of gastric cancer by subsite in operated and unoperated patients hospitalized for peptic ulcer. Am J Gastroenterol 2007 102 1185-1191
8. Valderrama J A., González M F., Pessoa-Mahana D, Tapia R A., Fillion H, Pautet F, Rodríguez J A., Theoduloz C, Schmeda-Hirschmann G. Studies on quinones. Part 41: synthesis and cytotoxity of isoquinoline- containing polycyclic quinones. Bioorg Med Chem 2006 14 5003-5011 (Pubitemid 43767131)