Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus

Journal of Ethnopharmacology

Volumn 94, Issue 1, 2004, Pages 185-189

  Guerrero, M F ^a,b   Puebla, P ^a   Carron R ^a   Martin M L ^a   San Roman L ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

(12R) 12 Hydroxycascarillone; 5 Hydroxy cis dehydrocrotonin; cis Dehydrocrotonin; neo Clerodane diterpenoids; trans Dehydrocrotonin; Vasorelaxant effect

Indexed keywords

12 HYDROXYCASCARILLONE; 5BETA HYDROXYDEHYDROCROTONIN; CLERODANE DERIVATIVE; CROTON EXTRACT; DITERPENOID; FLAVANOID; PHENYLEPHRINE; POTASSIUM; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CROTON; IC 50; MALE; NONHUMAN; RAT; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; CROTON; DITERPENES, CLERODANE; MALE; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 3242721428     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2004.05.018     Document Type: Article

References (14)

1. Bülbring E., Tomita T. Catecholamine action on smooth muscle. Pharmacological Reviews. 39:1987;49-96
2. Chang J. Medicinal herbs: drugs or dietary supplements? Biochemical Pharmacology. 59:2000;211-219
3. Correa J., Bernal H. Especies Vegetales Promisorias de los Países del Convenio Andrés Bello, Santafé de Bogotá Colombia T. VII:1992;314-322
4. García H. Flora Medicinal de Colombia, Santafé de Bogotá Colombia T. II:1975;87-91
5. Grynberg N.F., Echevarria A., Lima J.E., Pamplona S.S.R., Pinto A.C., Maciel M.A.M. Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara. Planta Medica. 65:1999;687-689
6. Guerrero M.F., Carrón R., Martín M.L., San Román L., Reguero M.T. Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats. Journal of Ethnopharmacology. 75:2001;33-36
7. Guerrero M.F., Puebla P., Carrón R., Martín M.L., Arteaga L., San Román L. Assessment of the antihypertensive and vasodilator effects of ethanolic extracts of some Colombian medicinal plants. Journal of Ethnopharmacology. 80:2002a;37-42
8. Guerrero M.F., Puebla P., Martín M.L., Carrón R., San Román L., Reguero M.T., Arteaga L. Inhibitory effect of N(G)-nitro-L-arginine methyl ester on the anti-adrenergic response elicited by ayanin in the pithed rat. Planta Medica. 68:2002;322-325
9. Guerrero M.F., Puebla P., Carrón R., Martín M.L., San Román L. Quercetin 3,7-dimethyl ether, a vasorelaxant flavonoid isolated from Croton schiedeanus Schlecht. Journal of Pharmacy and Pharmacology. 54:2002c;1373-1378
10. Itokawa H., Ichihara Y., Kojima H., Watanabe K., Takeya K. Nor-clerodane diterpenes from Croton cajucara. Phytochemistry. 28:1989;1667-1669
11. 2+ in rabbit aortic smooth muscle by norepinephrine and potassium after exposure to lanthanum and low temperature Journal of Pharmacology and Experimental Therapeutics. 211:1979;86-92
12. Karaky H., Weiss G.B. Calcium channels in smooth muscle. Gastroenterology. 87:1984;960-970
13. Kubo I., Asaka Y., Shibata K. 1 Insect growth inhibitory nor-diterpenes, cis-dehydrocrotonin and trans-dehydrocrotonin from Croton cajucara. Phytochemistry. 30:1991;2545-2546
14. Puebla P., López J.L., Guerrero M.F., Carrón R., Martín M.L., San Román L., San Feliciano A. Neo-clerodane diterpenoids from Croton schiedeanus. Phytochemistry. 62:2003;551-555