Micronization of Ginkgo biloba extract using supercritical antisolvent process

Powder Technology

Volumn 209, Issue 1-3, 2011, Pages 73-80

  Zhao, Chunjian ^a   Wang, Lei ^a   Zu, Yuangang ^a   Li, Chunying ^a   Liu, Shuaihua ^a   Yang, Lei ^a   Zhao, Xiuhua ^a   Zu, Baishi ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

Dissolution; Ginkgo biloba extract; Micronization; Supercritical antisolvent

Indexed keywords

DISSOLUTION RATES; GINKGO BILOBA EXTRACT; GINKGO BILOBA EXTRACTS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MEAN PARTICLE SIZE; MICRONIZATIONS; OPTIMUM CONDITIONS; ORTHOGONAL ARRAY DESIGNS; PRECIPITATION TEMPERATURE; SOLUTION CONCENTRATION; SOLUTION FLOW RATE; SPHERICAL PARTICLE; SUPERCRITICAL ANTISOLVENT; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL ANTISOLVENTS; TERPENE LACTONES;

CHROMATOGRAPHY; DISSOLUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; OLEFINS; OPTICAL GLASS; PARTICLES (PARTICULATE MATTER); SCANNING ELECTRON MICROSCOPY;

SUPERCRITICAL FLUID EXTRACTION;

ALCOHOL; FLAVONOID; GINKGO BILOBA EXTRACT; TERPENE LACTONE; TERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MANUFACTURE; DRUG SOLUBILITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICRONIZATION; PARTICLE SIZE; PRECIPITATION; PRESSURE; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL CARBON DIOXIDE; SUPERCRITICAL FLUID; TEMPERATURE;

EID: 79953027500     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2011.02.011     Document Type: Article

References (31)

1. http://www.usp.org/pdf/EN/USPNF/powderedGinkoppExtractRevisionBulletin.pdf.
2. Feng X., Zhang L., Zhu H. Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (GBE 761). Planta Med. 2009, 75:792-796.
3. Wang H., Ng T.B. Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein. Biochem. Biophys. Res. Commun. 2000, 279:407-411.
4. Mahmoud F., Abul H., Onadeko B., Khadadah M., Haines D., Morgan G. In vitro effects of Ginkgolide B on lymphocyte activation in atopic asthma: comparison with cyclosporin A. Jpn J. Pharmacol. 2000, 83:241-245.
5. Boonkaew T., Camper N.D. Biological activities of Ginkgo extracts. Phytomedicine 2005, 12:318-323.
6. Singh B., Kaur P., Gopichand, Singh R.D., Ahuja P.S. Biology and chemistry of Ginkgo biloba. Fitoterapia 2008, 79:401-418.
7. Rodríguez M., Ringstad L., Schäfer P., Just S., Hofer H.W., Malmsten M., Siegel G. Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (GBE 761) in cardiovascular high-risk patients. Atherosclerosis 2007, 192:438-444.
8. Logani S., Chen M.C., Tran T., Le T., Raffa R.B. Actions of Ginkgo biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Life Sci. 2000, 67:1389-1396.
9. Freedenberg R. Naturopathic/holistic treatment of mild to moderate depression. Nat. Med. J. 2009, 63:1-6.
10. Dongen M., van Rossum E., Kessels A., Sielhorst H., Knipschild P. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J. Clin. Epidemiol. 2003, 56:367-376.
11. Kudolo G.B., Wang W., Javors M., Blodgett J. The effect of the ingestion of Ginkgo biloba extract (GBE 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects - a double blind placebo-controlled, crossover study. Clin. Nutr. 2006, 25:606-616.
12. Canis M., Olzowy B., Welz C., Suckfüll M., Stelter K. Simvastatin and Ginkgo biloba in the treatment of subacute tinnitus: a retrospective study of 94 patients. Am. J. Otolaryngol. 2009, 10.1016/j.amjoto.2009.09.004.
13. Pittler M.H., Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am. J. Med. 2000, 108:276-281.
14. Sierpina V.S., Wollschlaeger B., Blumenthal M. Ginkgo biloba. Am. Fam. Physician 2003, 68:923-926.
15. Warrier G., Corzine A. A personal account of the early ginkgolide structural studies. Ginkgo biloba 2000, 517. Harwood, Amsterdam. T.A. van Beek (Ed.).
16. Nakanishi K. The marketing and economic aspects of Ginkgo biloba products. Ginkgo biloba 2000, 143. Harwood, Amsterdam. T.A. van Beek (Ed.).
17. J.Q. Hu, J.W. Bao, D.Z. Yao, X.L. Zhang, A water-soluble Ginkgo biloba extract production process, CN Patent 200810060422.2 (2008).
18. Demey H.E., Daelemans R.A., Verpooten G.A., De Broe M.E., Van Campenhout Ch.M., Lakiere F.V., Schepens P.J., Bossaert L.L. Propylene glycol-induced side effects during intravenous nitroglycerin therapy. Intensive Care Med. 1988, 14:221-226.
19. Yorgin P.D., Theodorou A.A., Al-Uzri A., Davenport K., Boyer-Hassen L.V., Johnson M.I. Propylene glycol-induced proximal renal tubular cell injury. Am. J. Kidney Dis. 1997, 30:134-139.
20. Tenorio A., Gordillo M.D., Pereyraa C.M., Martnez De La Ossa E.J. Supercritical antisolvent process applied to the pharmaceutical industry. Part. Sci. Technol. 2010, 28:262-266.
21. Shekunov B.Y., York P. Crystallization processes in pharmaceutical technology and drug delivery design. J. Cryst. Growth 2000, 211:122-136.
22. Dukhin S.S., Shen Y., Dave R., Pfeffer R. Droplet mass transfer, intradroplet nucleation and submicron particle production in two-phase flow of solvent-supercritical antisolvent emulsion. Colloids Surf. A 2005, 261:163-176.
23. Montes A., Tenorio A., Gordillo M.D., Pereyra C., Martínez de la Ossa E.J. Screening design of experiment applied to supercritical antisolvent precipitation of amoxicillin: exploring new miscible conditions. J. Supercrit. Fluids 2010, 51:399-403.
24. Zhao X.H., Zu Y.G., Li Q.Y., Wang M.X., Zu B.S., Zhang X.N., Jiang R., Zu C.L. Preparation and characterization of camptothecin powder micronized by a supercritical antisolvent (SAS) process. J. Supercrit. Fluids 2010, 51:412-419.
25. Imsanguan P., Pongamphai S., Douglas S., Teppaitoon W., Douglas P.L. Supercritical antisolvent precipitation of andrographolide from Andrographis paniculata extracts: effect of pressure, temperature and CO2 flow rate. Powder Technol. 2010, 200:246-253.
26. Lee L.Y., Wang C.H., Smith K.A. Supercritical antisolvent production of biodegradable micro- and nanoparticles for controlled delivery of paclitaxel. J. Control. Release 2008, 125:96-106.
27. Reverchon E., De Marco I., Della Porta G. Rifampicin microparticles production by supercritical antisolvent precipitation. Int. J. Pharm. 2002, 243:83-91.
28. Chen K., Zhang X., Pan J., Zhang W., Yin W. Gas antisolvent precipitation of Ginkgo ginkgolides with supercritical CO2. Powder Technol. 2005, 152:127-132.
29. Y.G. Zu, B.S. Zu, X.H. Zhao, L. Yang, Q.Y. Li, B.Y. Zhang, A water-soluble nano-materials prepared by supercritical anti-solvent device, CN Patent 200810064220.5 (2008).
30. Xie J., Ding C., Ge Q., Zhou Z., Zhi X. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats. J. Chromatogr. B 2008, 864:87-94.
31. States pharmacopoeia commission Pharmacopoeia of the Peoples Republic of China 2005, Chemical Industry Press, Beijing, (Part I). 2005 Ed.