The "parallel pathway": A novel nutritional and metabolic approach to cancer patients

Internal and Emergency Medicine

Volumn 6, Issue 2, 2011, Pages 105-112

  Muscaritoli, Maurizio ^a   Molfino, Alessio ^a   Gioia, Gianfranco ^a   Laviano, Alessandro ^a   Fanelli, Filippo Rossi ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cancer; Malnutrition; Muscle wasting; Nutrition

Indexed keywords

ANTINEOPLASTIC AGENT;

ANOREXIA; CACHEXIA; DIET THERAPY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; LIPID METABOLISM; MALNUTRITION; METABOLISM; NEOPLASM; NUTRITIONAL STATUS; PROGNOSIS; PROTEIN INTAKE; REVIEW; RISK FACTOR; SKELETAL MUSCLE; WEIGHT REDUCTION;

ANOREXIA; ANTINEOPLASTIC AGENTS; BLOOD GLUCOSE; CACHEXIA; DIETARY PROTEINS; HUMANS; LIPID METABOLISM; MALNUTRITION; METABOLISM; MUSCLE, SKELETAL; NEOPLASMS; NUTRITIONAL STATUS; PROGNOSIS; RISK FACTORS; WEIGHT LOSS;

EID: 79953023673     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-010-0426-1     Document Type: Review

References (49)

1. MacDonald N, Easson AM, Mazurak VC et al (2003) Understanding and managing cancer cachexia. J Am Coll Surg 197: 143-161.
2. Muscaritoli M, Anker SD, Argilés J et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr (Epub ahead of print).
3. Bossola M, Muscaritoli M, Costelli P, Grieco G, Monelli G, Pacelli F, Rossi Fanelli F, Doglietto GB, Baccino FM (2003) Increased muscle proteasome activity correlates with disease severity in gastric cancer patients. Ann Surg 237: 384-389.
4. Bossola M, Muscaritoli M, Costelli P, Bellantone R, Pacelli F, Busquets S, Argiles J, Lopez-Soriano FJ, Civello IM, Baccino FM, Rossi Fanelli F, Doglietto GB (2001) Increased muscle ubiquitin mRNA levels in gastric cancer patients. Am J Physiol 280: R1518-R1523.
5. Laviano A, Meguid MM, Rossi Fanelli F (2003) Cancer anorexia: clinical implications, pathogenesis and therapeutic strategies. Lancet Oncol 4: 686-694.
6. Laviano A, Meguid MM, Rossi Fanelli F (2003) Improving food intake in anorectic cancer patients. Curr Opin Clin Nutr Metab Care 6: 421-426.
7. Argiles JM, Lopez-Soriano FJ (1998) Catabolic proinflammatory cytokines. Curr Opin Clin Nutr Metab Care 1: 245-251.
8. Dempsey DT, Knox LS, Mullen JL, Miller C, Feurer ID, Buzby GP (1996) Energy expenditure in malnourished patients with colorectal cancer. Arch Surg 121: 789-795.
9. Gibney E, Elia M, Jebb SA, Murgatroyd P, Jennings G (1997) Total energy expenditure in patients with non small-cell lung cancer: results of a validated study using the bicarbonate-urea method. Metabolism 46: 1412-1417.
10. Falconer JS, Fearon KC, Plester CE, Ross JA, Carter DC (1994) Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 219: 325-331.
11. Rossi Fanelli F, Cangiano C, Muscaritoli M, Conversano L, Torelli GF, Cascino A (1995) Tumor induced changes in host metabolism: a possible marker of neoplastic disease. Nutrition 11: 595-600.
12. Mathupala SP, Rempel A, Pendersen PL (1995) Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J Biol Chem 270: 16918-16925.
13. De Blaauw I, Deutz NE, von Meyenfeldt MF (1997) Metabolic changes of cancer cachexia-first of two part. Clin Nutr 16: 169-176.
14. Tajek JA, Manglik S, Abemayor E (1997) Insulin secretion, glucose production and insulin sensitivity in underweight and normal weight volunteers, and in underweight and normal-weight cancer patients. Metabolism 46: 140-145.
15. Skolnik EY, Marcusohn J (1996) Inhibition of insulin receptor signaling by TNF: potential role in obesity and non-insulin-dependent diabetes mellitus. Cytokine Growth Fact Rev 7: 161-173.
16. Halton JM, Nazir DJ, McQueen MJ, Barr RD (1998) Blood lipid profiles in children with acute lymphoblastic leukaemia. Cancer 83: 379-384.
17. Costelli P, Tessitore L, Batetta B et al (1999) Alterations of lipid and cholesterol metabolism in cachectic tumor-bearing rats are prevented by insulin. J Nutr 129: 700-706.
18. Muscaritoli M, Cangiano C, Cascino A, Ceci F, Giacomelli L, Cardelli-Cangiano P, Mulieri M, Rossi Fanelli F (1990) Plasma clearance of exogenous lipids in patients with malignant disease. Nutrition 6: 147-151.
19. Sakurai Y, Klein S (1998) Metabolic alterations in patients with cancer: nutritional implications. Surg Today 28: 247-257.
20. Ishiko O, Nishimura S, Yasui T et al (1999) Metabolic and morphologic characteristics of adipose tissue associated with the growth of malignant tumors. Jpn J Cancer Res 90: 655-659.
21. Gullett N, Rossi P, Kucuk O, Johnstone PA (2009) Cancer-induced cachexia: a guide for the oncologist. J Soc Integr Oncol 7: 155-169.
22. Korber J, Pricelius S, Heidrich M, Muller MJ (1999) Increased lipid utilization in weight losing and weight stable cancer patients with normal body weight. Eur J Clin Nutr 53: 540-545.
23. Fearon KCH (1992) The mechanisms and treatment of weight loss in cancer. Proc Nutr Soc 51: 251-265.
24. López-Soriano J, Carbó N, Tessitore L, López-Soriano FJ, Argilés JM (1999) Leptin and tumor growth in rats. Int J Cancer 81: 726-729.
25. Wallace AM, Sattar N, McMillan DC (1998) Effect of weight loss and the inflammatory response on leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res 4: 2977-2979.
26. Costelli P, Baccino FM (2000) Cancer cachexia: from experimental models to cancer patients. Curr Opin Clin Nutr Metab Care 3: 177-181.
27. Kadowaki M, Kanazawa T (2003) Amino acids as regulators of proteolysis. J Nutr 133: 2052S-2056S.
28. Temparis S, Asensi M, Taillandier D et al (1994) Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats. Cancer Res 54: 5568-5573.
29. Llovera M, Garcia-Martinez C, Agell N, Lopez-Soriano FJ, Argiles JM (1995) Muscle wasting associated with cancer cachexia is linked to an important activation of the ATP-dependent ubiquitin-mediated proteolysis. Int J Cancer 61: 138-141.
30. Lundholm K, Ekman L, Karlberg I, Edstrom S, Schersten T (1980) Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice. Cancer Res 40: 1680-1685.
31. Tessitore L, Costelli P, Bonetti G, Baccino FM (1993) Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals. Arch Biochem Biophys 306: 52-58.
32. Deval C, Mordier S, Obled C et al (2001) Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting. Biochem J 360: 143-150.
33. Jagoe RT, Redfern CP, Roberts RG, Gibson GJ, Goodship TH (2002) Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy. Clin Sci 102: 353-361.
34. 2+-dependent proteolysis in the skeletal muscle and heart in cancer cachexia. Br J Cancer 84: 946-950.
35. 2+-dependent proteolytic systems in the muscle of tumour-bearing rats. Cytokine 19: 1-5.
36. Wray CJ, Sun X, Gang GI, Hasselgren PO (2002) Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. J Surg Res 104: 82-87.
37. Tidball JG, Spencer MJ (2002) Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse. J Physiol 545: 819-828.
38. Guttridge DC, Mayo MW, Madrid LW et al (2000) NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 289: 2363-2366.
39. Sabourin LA, Rudnicki MA (2000) The molecular regulation of myogenesis. Clin Genet 57: 16-25.
40. Costelli P, Muscaritoli M, Bossola M et al (2005) Skeletal muscle wasting in tumour-bearing rats is associated with MyoD down-regulation. Int J Oncol 26: 1663-1668.
41. Costelli P, Muscaritoli M, Bonetto A et al (2008) Muscle myostatin signalling is enhanced in experimental cancer cachexia. Eur J Clin Invest 38: 531-538.
42. van Royen M, Carbo N, Busquets S, Alvarez B, Quinn LS, Lopez-Soriano FJ et al (2000) DNA fragmentation occurs in skeletal muscle during tumour growth: a link with cancer cachexia? Biochem Biophysic Res Commun 270: 533-537.
43. Bossola M, Mirabella M, Ricci E, Costelli P, Pacelli F, Tortorelli AP, Muscaritoli M, Rossi Fanelli F, Baccino FM, Tonali PA, Doglietto GB (2006) Skeletal muscle apoptosis is not increate in gastric cancer patients with mild-moderate weight loss. Int J Biochem Cell Biol 38: 1561-1570.
44. Ross PJ, Ashely S, Norton A et al (2004) Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers? Br J Cancer 90: 1905-1911.
45. Ravasco P, Monteiro-Grillo I, Vidal PM et al (2005) Dietary counseling improves patients outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy. J Clin Oncol 23: 1431-1438.
46. Linee guida SINPE per la Nutrizione Artificiale Ospedaliera (2002) Rivista Italiana di Nutrizione Parenterale ed Enterale S1-S171.
47. Arends J, Bodoky G, Bozzetti F et al (2006) ESPEN guidelines on adult enteral nutrition: non-surgical oncology. Clin Nutr 25: 245-259.
48. Muscaritoli M, Grieco G, Capria S, Iori AP, Rossi Fanelli F (2002) Nutritional and metabolic support in patients undergoing bone marrow transplantation. Am J Clin Nutr 75: 183-190.
49. Bozzetti F, Arends J, Lundholm K, Micklewright A, Zurcher G, Muscaritoli M, ESPEN (2009) ESPEN Guidelines on parenteral nutrition: non-surgical oncology. Clin Nutr 28: 445-454.