Insulin secretion, glucose production, and insulin sensitivity in underweight and normal-weight volunteers, and in underweight and normal- weight cancer patients: A clinical research center study

Metabolism: Clinical and Experimental

Volumn 46, Issue 2, 1997, Pages 140-145

  Tayek, John A ^a,b   Manglik, Savita ^a   Abemayor, Elliot ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; TOLBUTAMIDE; TRITIUM; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY WEIGHT; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; HEAD AND NECK CARCINOMA; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALNUTRITION; NUTRITIONAL STATUS; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

EID: 0031056007     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90291-2     Document Type: Article

References (37)

1. Rao RH: Diabetes in the undernourished: Coincidence or consequence? Endocr Rev 9:67-87, 1988
2. Rao RH, Menon RK: Chronic malnutrition impairs insulin sensitivity through receptor and postreceptor defects in rats with mild streptozocin diabetes. Metabolism 42:772-779, 1993
3. Crace CJ, Swenne I, Kohn PG, et al: Protein-energy malnutrition induces changes in insulin sensitivity. Diabete Metab 16:484-491, 1990
4. Esriva E, Kergoat M, Bailbe AM, et al: Increased insulin action in the rat after protein malnutrition early in life. Diabetologia 34:559-564, 1991
5. Tayek JA: A review of cancer cachexia and abnormal glucose metabolism in humans with cancer. J Am Coll Nutr 11:445-456, 1992
6. Rutanen EM, Stenman S, Blum W, et al: Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: Comparison of endometrial cancer patients with healthy controls. J Clin Endocrinol Metab 77:199-204, 1993
7. Forbes GB, Bruining GJ: Urinary creatinine excretion and lean body mass. Am J Clin Nutr 29:1359-1366, 1976
8. Bergman RN, Phillips LS, Cobelli C: Physiological evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1457, 1981
9. Kuzuya H: Determination of free and total insulin and C-peptide in insulin-treated diabetes. Diabetes 26:22-29, 1977
10. Odell WD, Rayford PL, Ross GT: Simplified, partially automated method for radioimmunoassay of human thyroid-stimulating, growth, luteinizing, and follicle-stimulating hormones. J Lab Clin Med 70:973-980, 1967
11. Farmer RW, Prince CE: Plasma cortisol determination: Radioimmunoassay and competitive binding compared. Clin Chem 20:411-414, 1974
12. Unger RH, Eisentraut LE, McCall MS, et al: Glucagon antibodies and an immunoassay for glucagon. Proc Exp Biol Med 120:621-623, 1959
13. Anna-Maija T, Maury CPJ: Radioimmunoassay of tumor necrosis factor in serum. Clin Chem 33:2024-2027, 1987
14. Daughaday WA, Mariz IK, Blether SL: Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-extracted serum. J Clin Endocrinol Metab 51:781-788, 1980
15. 13C-glucose. Biol Mass Spectrom 20:186-190, 1991
16. Zuniga-Guajardo S, Garfinkel PE, Zinman B: Changes in insulin sensitivity and clearance in anorexia nervosa. Metabolism 35:1096-1100, 1986
17. Church JM, Hill GL: Impaired glucose metabolism in surgical patients improved by intravenous nutrition: Assessment by the euglycemic-hyperinsulinemic clamp. Metabolism 37:505-509, 1988
18. Polonsky KS, Gumbiner B, Ostrega D, et al: Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes 43:871-877, 1994
19. Basu A, Alzaid A, Dinneen S, et al: Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance. J Clin Invest 97:2351-2361, 1996
20. Tayek JA: Reduced non-oxidative glucose utilization in cancer patients is associated with a low triiodothyronine concentration. J Am Coll Nutr 14:341-348, 1995
21. Shaw JHF, Humberstone DM, Wolfe RR: Energy and protein metabolism in sarcoma patients. Ann Surg 207:283-289, 1983
22. Tayek JA, Bulcavage L, Chlebowski RT: Relationship of hepatic glucose production (HGP) to growth hormone and severity of malnutrition in a population with colorectal carcinoma. Cancer Res 50:2119-2122, 1990
23. Cersosimo E, Pisters PWT, Pesola G, et al: The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer cachexia. Surgery 109:459-467, 1991
24. Vail DM, Ogilvie GK, Wheeler SL, et al: Alterations in carbohydrate metabolism in canine lymphoma. J Vet Int Med 4:8-11, 1990
25. Copeland GP, Leinster SJ, Davis JC, et al: Postoperative glucose metabolism as assessed by the hyperglycemic glucose clamp. J R Coll Surg Edinb 33:330-338, 1988
26. Yoshikawa T, Noguchi Y, Mastsumoto A: Effects of tumor removal and body weight loss on insulin resistance in patients with cancer. Surgery 116:62-66, 1994
27. Minn H, Nuutila P, Lindholm P, et al: In-vivo effects of insulin on tumor and skeletal muscle glucose metabolism in patients with lymphoma. Cancer 73:1490-1498, 1994
28. Reichard GA, Moury NF, Hochella NJ, et al: Quantitative estimation of the Cori cycle in the human. J Biol Chem 238:495-501, 1963
29. Long CL, Merrick H, Grecos G, et al: Glucose metabolism and colorectal carcinoma. Metabolism 39:494-501, 1990
30. Lundholm K, Edstrom S, Karlberg I, et al: Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients. Cancer 50:1142-1150, 1982
31. McCall JL, Tuckey JA, Parry BR: Serum TNF-alpha and insulin resistance in gastrointestinal cancer. Br J Surg 79:1361-1363, 1992
32. Tayek JA, Katz J. Glucose production, recycling, coricycle and gluconeogenesis in humans with and without cancer: Relationship to serum cortisol concentration. Am J Physiol (in press)
33. Tayek JA, Brasel J: Failure of anabolism in malnourished cancer patients with growth hormone administration. J Clin Endocrinol Metab 80:2082-2087, 1995
34. Tayek JA: Growth hormone physiology and glucose metabolism in lung cancer patients. Endocrine 2:1055-1059, 1994
35. Hussain MA, Schmilz O, Mengel A, et al: IGF-1 stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans. J Clin Invest 92:2249-2256, 1993
36. Muller MJ, Burger AG, Ferrannini E, et al: Glucoregulatory function of thyroid hormones: Role of pancreatic hormones. Am J Physiol 256:E101-E110, 1989
37. Kahn SE, Prigeon RL, McCulloch DK, et al: Quantification of the relationship between insulin sensitivity and B-cell function in human subjects: Evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993