C-terminal splice variants of the μ-opioid receptor: Existence, distribution and functional characteristics

Journal of Neurochemistry

Volumn 104, Issue 4, 2008, Pages 937-945

  Oldfield, Sue ^a   Braksator, Ellen ^a   Rodriguez Martin, Ivan ^a   Bailey, Chris P ^a,b   Donaldson, Lucy F ^a   Henderson, Graeme ^a   Kelly, Eamonn ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

opioid receptor; G protein coupled receptor; Splice variant

Indexed keywords

DYNAMIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DESENSITIZATION; ENDOCYTOSIS; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MALE; MEDICAL LITERATURE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

AMINO ACID SEQUENCE; ANALGESICS, OPIOID; ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN ISOFORMS; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU;

RATTUS;

EID: 38449087176     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05057.x     Document Type: Article

References (27)

1. Abbadie C., Pan Y.-X. Pasternak G. W. (2000a) Differential distribution in rat brain of mu opioid receptor carboxy terminal splice variants MOR-1C- and MOR-1-like immunoreactivity: evidence for region-specific processing. J. Comp. Neurol. 419, 244 256.
2. Abbadie C., Pan Y.-X., Drake C. T. Pasternak G. W. (2000b) Comparative immunohistochemical distributions of carboxy terminus epitopes from the mu-opioid receptor splice variants MOR-1D and MOR-1C in the mouse and rat CNS. Neuroscience 100, 141 153.
3. Bailey C. P., Couch D., Johnson E., Griffiths K., Kelly E. Henderson G. (2003) μ-Opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J. Neurosci. 23, 10515 10520.
4. Bailey C. P., Kelly E. Henderson G. (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of μ-opioid receptors in mature rat locus ceruleus neurons. Mol. Pharmacol. 66, 1592 1598.
5. Bailey C. P., Smith F. L., Kelly E., Dewey W. L. Henderson G. (2006) How important is protein kinase C in μ-opioid receptor desensitisation and morphine tolerance? Trends Pharmacol. Sci. 27, 558 565.
6. Chen Y., Mestek A., Liu J. A. Yu L. (1993) Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol. Pharmacol. 44, 8 12.
7. Damke H., Baba T., Warnock D. E. Schmid S. L. (1994) Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127, 915 934.
8. Fukuda K., Kato S., Mori K., Iwabe N., Miyata T., Nishi M. Takeshima H. (1993) Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. FEBS Lett. 327, 311 314.
9. Johnson E. A., Oldfield S., Braksator E., Gonzalez-Cuello A., Couch D., Hall K. J., Mundell S. J., Bailey C. P., Kelly E. Henderson G. (2006) Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells. Mol. Pharmacol. 70, 676 685.
10. Kilpatrick G., Dautzenberg F. M., Martin G. R. Eglen R. M. (1999) 7TM receptors: the splicing on the cake. Trends Pharmacol. Sci. 20, 294 301.
11. Koch T., Schulz S., Schröder H., Wolf R., Raulf E. Höllt V. (1998) Carboxyl-terminal splicing of the rat μ opioid receptor modulates agonist-mediated internalization and receptor resensitization. J. Biol. Chem. 273, 13652 13657.
12. Koch T., Schulz S., Pfeiffer M., Klutzny M., Schröder H., Kahl E. Höllt V. (2001) C-terminal splice variants of the mouse μ-opioid receptor differ in morphine-induced internalisation and receptor resensitisation. J. Biol. Chem. 276, 31408 31414.
13. Mundell S. J., Matharu A.-L., Pula G., Roberts P. J. Kelly E. (2001) Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent. J. Neurochem. 78, 546 551.
14. Mundell S. J., Matharu A.-L., Pula G., Holman D., Roberts P. J. Kelly E. (2002) Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mol. Pharmacol. 61, 1114 1123.
15. Pan Y.-X., Xu J., Bolan E., Abbadie C., Chang A., Zuckerman A., Rossi G. Pasternak G. W. (1999) Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. Mol. Pharm. 56, 396 403.
16. Pan Y.-X., Xu J., Rossi G. C., Xu M. M., Mahurter L., Bolan E. A. Pasternak G. W. (2000) Identification and characterization of a novel promoter of a mouse mu opioid receptor gene (MOR-1) that directs alternative splicing and differential expression of eight new variants. Soc. Neurosci. 26, 2097.
17. Pasternak G. W. (2004) Multiple opiate receptors: déja vu all over again. Neuropharmacology 47, 312 323.
18. Pasternak D. A., Pan L., Xu J., Yu R., Xu M.-M., Pasternak G. W. Pan Y.-X. (2004) Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J. Neurochem. 91, 881 890.
19. Rat Genome Sequencing Project Consortium. (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428, 493 521.
20. Sambrook J., Fritsch E. F. Maniatis T. (1989) Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Woodbury, NY, USA.
21. 1C- like μ-opioid receptor mRNA in rats. J. Comp. Neurol. 473, 213 232.
22. Schulz S., Schreff M., Koch T., Zimprich A., Gramsch C., Elde R. Höllt V. (1998) Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system. Neuroscience 82, 613 622.
23. Schulz S., Mayer D., Pfeiffer M., Stumm R., Koch T. Höllt V. (2004) Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J. 23, 3282 3289.
24. Thompson R. C., Mansour A., Akil H. Watson S. J. (1993) Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron 11, 903 913.
25. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharm. 47, 848 854.
26. Williams J. T., Christie M. J. Manzoni O. (2001) Cellular and synaptic adaptions mediating opioid dependence. Physiol. Rev. 81, 299 343.
27. Zimprich A., Simon T. Höllt V. (1995) Cloning and expression of an isoform of the rat μ opioid receptor (rMOR1B) which differs in agonist induced desensitisation from rMOR1. FEBS Lett. 359, 142 146.