The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4280-4291

  Kirabo, Annet ^a   Embury, Jennifer ^a   Kiss, Ró Bert ^b   Polgár, Tímea ^c   Gali, Meghanath ^d   Majumder, Anurima ^a   Bisht, Kirpal S ^d   Cogle, Christopher R ^a   Keseru, György M ^c   Sayeski, Peter P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; BONE MARROW; CASPASES; CELL LINES; CELL-CYCLE ARREST; DRUG EFFICACY; ENGRAFTMENT; HUMAN DISEASE; IN-VITRO; MOUSE MODELS; PATHOLOGICAL CELLS; PERIPHERAL BLOOD; STRUCTURE-BASED; TYROSINE KINASE; TYROSINE KINASE INHIBITOR; VIRTUAL SCREENING;

AMINO ACIDS; CELL CULTURE; CELL DEATH; ENZYME INHIBITION; ENZYMES; GROWTH KINETICS; PHOSPHORYLATION;

CELL GROWTH;

CASPASE 3; CASPASE 7; G6; JANUS KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN TYROSINE KINASE INHIBITOR; STAT5 PROTEIN; UNCLASSIFIED DRUG; JAK2 PROTEIN, HUMAN; JAK2 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLAST CELL; BLOOD; BONE MARROW CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERYTHROID CELL; ERYTHROLEUKEMIA; HEMATOPOIESIS; HUMAN; HUMAN CELL; HYPERPLASIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPLENOMEGALY; AMINO ACID SUBSTITUTION; ANIMAL; CELL CYCLE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MISSENSE MUTATION; MOUSE MUTANT; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; HUMANS; JANUS KINASE 2; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MICE, MUTANT STRAINS; MUTATION, MISSENSE; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; STILBENES;

EID: 79952998703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.200774     Document Type: Article

References (32)

1. Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., Scott, M. A., Erber, W. N., and Green, A. R. (2005) Lancet 365, 1054-1061
2. James, C., Ugo, V., Le Couédic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., and Vainchenker, W. (2005) Nature 434, 1144-1148
3. Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., Adelsperger, J., Koo, S., Lee, J. C., Gabriel, S., Mercher, T., D'Andrea, A., Fröhling, S., Döhner, K., Marynen, P., Vandenberghe, P., Mesa, R. A., Tefferi, A., Griffin, J. D., Eck, M. J., Sellers, W. R., Meyerson, M., Golub, T. R., Lee, S. J., and Gilliland, D. G. (2005) Cancer Cell 7, 387-397
4. Kralovics, R., Passamonti, F., Buser, A. S., Teo, S. S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., and Skoda, R. C. (2005) N. Engl. J. Med. 352, 1779-1790
5. Zhao, R., Xing, S., Li, Z., Fu, X., Li, Q., Krantz, S. B., and Zhao, Z. J. (2005) J. Biol. Chem. 280, 22788-22792
6. Jelinek, J., Oki, Y., Gharibyan, V., Bueso-Ramos, C., Prchal, J. T., Verstovsek, S., Beran, M., Estey, E., Kantarjian, H. M., and Issa, J. P. (2005) Blood 106, 3370-3373
7. Jones, A. V., Kreil, S., Zoi, K., Waghorn, K., Curtis, C., Zhang, L., Score, J., Seear, R., Chase, A. J., Grand, F. H., White, H., Zoi, C., Loukopoulos, D., Terpos, E., Vervessou, E. C., Schultheis, B., Emig, M., Ernst, T., Lengfelder, E., Hehlmann, R., Hochhaus, A., Oscier, D., Silver, R. T., Reiter, A., and Cross, N. C. (2005) Blood 106, 2162-2168
8. Levine, R. L., Loriaux, M., Huntly, B. J., Loh, M. L., Beran, M., Stoffregen, E., Berger, R., Clark, J. J., Willis, S. G., Nguyen, K. T., Flores, N. J., Estey, E., Gattermann, N., Armstrong, S., Look, A. T., Griffin, J. D., Bernard, O. A., Heinrich, M. C., Gilliland, D. G., Druker, B., and Deininger, M. W. (2005) Blood 106, 3377-3379
9. Xing, S., Wanting, T. H., Zhao, W., Ma, J., Wang, S., Xu, X., Li, Q., Fu, X., Xu, M., and Zhao, Z. J. (2008) Blood 111, 5109-5117
10. Wernig, G., Kharas, M. G., Okabe, R., Moore, S. A., Leeman, D. S., Cullen, D. E., Gozo, M., McDowell, E. P., Levine, R. L., Doukas, J., Mak, C. C., Noronha, G., Martin, M., Ko, Y. D., Lee, B. H., Soll, R. M., Tefferi, A., Hood, J. D., and Gilliland, D. G. (2008) Cancer Cell 13, 311-320
11. Lacout, C., Pisani, D. F., Tulliez, M., Gachelin, F. M., Vainchenker, W., and Villeval, J. L. (2006) Blood 108, 1652-1660
12. Lipka, D. B., Hoffmann, L. S., Heidel, F., Markova, B., Blum, M. C., Breitenbuecher, F., Kasper, S., Kindler, T., Levine, R. L., Huber, C., and Fischer, T. (2008) Mol. Cancer Ther. 7, 1176-1184
13. Ferrajoli, A., Faderl, S., Van, Q., Koch, P., Harris, D., Liu, Z., Hazan-Halevy, I., Wang, Y., Kantarjian, H. M., Priebe, W., and Estrov, Z. (2007) Cancer Res. 67, 11291-11299
14. Gozgit, J. M., Bebernitz, G., Patil, P., Ye, M., Parmentier, J., Wu, J., Su, N., Wang, T., Ioannidis, S., Davies, A., Huszar, D., and Zinda, M. (2008) J. Biol. Chem. 283, 32334-32343
15. Pardanani, A., Lasho, T., Smith, G., Burns, C. J., Fantino, E., and Tefferi, A. (2009) Leukemia 23, 1441-1445
16. Antonysamy, S., Hirst, G., Park, F., Sprengeler, P., Stappenbeck, F., Steensma, R., Wilson, M., and Wong, M. (2009) Bioorg. Med. Chem. Lett 19, 279-282
17. Sandberg, E. M., Ma, X., He, K., Frank, S. J., Ostrov, D. A., and Sayeski, P. P. (2005) J. Med. Chem. 48, 2526-2533
18. Sayyah, J., Magis, A., Ostrov, D. A., Allan, R. W., Braylan, R. C., and Sayeski, P. P. (2008) Mol. Cancer Ther. 7, 2308-2318
19. Kiss, R., Polgár, T., Kirabo, A., Sayyah, J., Figueroa, N. C., List, A. F., Sokol, L., Zuckerman, K. S., Gali, M., Bisht, K. S., Sayeski, P. P., and Keseru, G. M. (2009) Bioorg. Med. Chem. Lett 19, 3598-3601
20. Larrosa, M., Tomás-Barberán, F. A., and Espín, J. C. (2003) J. Agric. Food Chem. 51, 4576-4584
21. Le Corre, L., Chalabi, N., Delort, L., Bignon, Y. J., and Bernard-Gallon, D. J. (2005) Mol. Nutr. Food Res. 49, 462-471
22. Kimura, Y. (2005) In Vivo 19, 37-60
23. Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G., and Goldberg, D. M. (1995) Clin. Chim. Acta 235, 207-219
24. Geahlen, R. L., and McLaughlin, J. L. (1989) Biochem. Biophys. Res. Commun. 165, 241-245
25. Swanson-Mungerson, M., Ikeda, M., Lev, L., Longnecker, R., and Portis, T. (2003) J. Antimicrob. Chemother. 52, 152-154
26. Baker, S. J., Rane, S. G., and Reddy, E. P. (2007) Oncogene. 26, 6724-6737
27. Socolovsky, M., Fallon, A. E., Wang, S., Brugnara, C., and Lodish, H. F. (1999) Cell 98, 181-191
28. Majumder, A., Govindasamy, L., Magis, A., Kiss, R., Polgár, T., Baskin, R., Allan, R. W., Agbandje-McKenna, M., Reuther, G. W., Keseru, G. M., Bisht, K. S., and Sayeski, P. P. (2010) J. Biol. Chem. 285, 31399-31407
29. Santos, F. P., Kantarjian, H. M., Jain, N., Manshouri, T., Thomas, D. A., Garcia-Manero, G., Kennedy, D., Estrov, Z., Cortes, J., and Verstovsek, S. (2010) Blood 115, 1131-1136
30. Koppikar, P., Abdel-Wahab, O., Hedvat, C., Marubayashi, S., Patel, J., Goel, A., Kucine, N., Gardner, J. R., Combs, A. P., Vaddi, K., Haley, P. J., Burn, T. C., Rupar, M., Bromberg, J. F., Heaney, M. L., de Stanchina, E., Fridman, J. S., and Levine, R. L. (2010) Blood 115, 2919-2927
31. Tyner, J. W., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M. M., Druker, B. J., Burns, C. J., Fantino, E., and Deininger, M. W. (2010) Blood 115, 5232-5240
32. Wadleigh, M., and Tefferi, A. (2010) Clin. Adv. Hematol. Oncol. 8, 557-563