Diaphragmatic dysfunction in mechanical ventilation

Current Opinion in Anaesthesiology

Volumn 24, Issue 2, 2011, Pages 214-218

  Haitsma, Jack J ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Controlled mechanical ventilation; diaphragm; muscle atrophy; ventilator induced lung injury

Indexed keywords

MUSCLE PROTEIN;

ARTICLE; ARTIFICIAL VENTILATION; DIAPHRAGM INJURY; DIAPHRAGM MOVEMENT; DISEASE COURSE; HUMAN; LONG TERM CARE; MALNUTRITION; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RISK FACTOR; SEPSIS; VENTILATOR INDUCED LUNG INJURY;

ANIMALS; DIAPHRAGM; HUMANS; MUSCLE PROTEINS; RESPIRATION, ARTIFICIAL; VENTILATOR-INDUCED LUNG INJURY;

EID: 79952993174     PISSN: 09527907     EISSN: None     Source Type: Journal    
DOI: 10.1097/ACO.0b013e3283440185     Document Type: Article

References (38)

1. Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet 1967;2:319-323.
2. Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685-1693. (Pubitemid 41464707)
3. Herridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003;348:683-693. (Pubitemid 36237037)
4. Carson SS. Outcomes of prolonged mechanical ventilation. Curr Opin Crit Care 2006;12:405-411. (Pubitemid 44341704)
5. Tobin MJ, Laghi F, Jubran A. Narrative review: ventilator-induced respiratory muscle weakness. Ann Intern Med 2010;153:240-245. An excellent review on diaphragm dysfunction, and provides advice on how to reduce the risk for VIDD in patients.
6. Laghi F, Cattapan SE, Jubran A, et al. Is weaning failure caused by lowfrequency fatigue of the diaphragm? Am J Respir Crit Care Med 2003;167:120-127. (Pubitemid 36076069)
7. ARDS Network: ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308.
8. Haitsma JJ. Physiology of mechanical ventilation. Crit Care Clin 2007;23:117-134. (Pubitemid 46401130)
9. Dos Santos CC, Slutsky AS. The contribution of biophysical lung injury to the development of biotrauma. Annu Rev Physiol 2006;68:585-618.
10. Ferring M, Vincent JL. Is outcome from ARDS related to the severity of respiratory failure? Eur Respir J 1997;10:1297-1300. (Pubitemid 27278249)
11. Esteban A, Anzueto A, Frutos F, et al. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002;287:345-355. (Pubitemid 34251968)
12. Tremblay LN, Slutsky AS. Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 1998;110:482-488. (Pubitemid 28516123)
13. Vreugdenhil HA, Heijnen CJ, Plotz FB, et al. Mechanical ventilation of healthy rats suppresses peripheral immune function. Eur Respir J 2004;23:122-128. (Pubitemid 38088508)
14. Imai Y, Parodo J, Kajikawa O, et al. Injurious mechanical ventilation and endorgan epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003;289:2104-2112. (Pubitemid 37430212)
15. Ranieri VM, Suter PM, Tortorella C, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 1999;282:54-61. (Pubitemid 29318933)
16. Ranieri VM, Giunta F, Suter PM, et al. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 2000;284:43-44. (Pubitemid 30445657)
17. Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;169:336-341. (Pubitemid 38134811)
18. Perry SF, Similowski T, Klein W, et al. The evolutionary origin of the mammalian diaphragm. Respir Physiol Neurobiol 2010;171:1-16.
19. Anzueto A, Peters JI, Tobin MJ, et al. Effects of prolonged controlled mechanical ventilation on diaphragmatic function in healthy adult baboons. Crit Care Med 1997;25:1187-1190. (Pubitemid 27310260)
20. Yang L, Luo J, Bourdon J, et al. Controlled mechanical ventilation leads to remodeling of the rat diaphragm. Am J Respir Crit Care Med 2002;166:1135-1140. (Pubitemid 35178714)
21. Le Bourdelles G, Viires N, Boczkowski J, et al. Effects of mechanical ventilation on diaphragmatic contractile properties in rats. Am J Respir Crit Care Med 1994;149:1539-1544. (Pubitemid 24175972)
22. Radell PJ, Remahl S, Nichols DG, et al. Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm function. Intensive Care Med 2002;28:358-364. (Pubitemid 34230660)
23. Doucet M, Dube A, Joanisse DR, et al. Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD. Thorax 2010;65:963-970.
24. Bodine SC, Latres E, Baumhueter S, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001;294:1704-1708. (Pubitemid 33104839)
25. Mitch WE, Goldberg AL. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 1996;335:1897-1905. (Pubitemid 26419198)
26. Gomes MD, Lecker SH, Jagoe RT, et al. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci USA 2001;98:14440-14445. (Pubitemid 33121410)
27. Shanely RA, Zergeroglu MA, Lennon SL, et al. Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med 2002;166:1369-1374. (Pubitemid 35292704)
28. McClung JM, Kavazis AN, DeRuisseau KC, et al. Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med 2007;175:150-159. (Pubitemid 46115086)
29. Levine S, Nguyen T, Taylor N, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008;358:1327-1335. (Pubitemid 351468409)
30. Levine S, Biswas C, Dierov J, et al. Increased proteolysis, myosin depletion and atrophic AKT-FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 2010. [Epub ahead of print]. PMID: 20833824 Additional data form the groundbreaking 2008 study providing evidence for the first time that prolonged mechanical ventilation causes diaphragm dysfunction in brain-dead patient, by increased proteolysis and atrophic signaling.
31. Hermans G, Agten A, Testelmans D, et al. Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Crit Care 2010;14: R127. A study demonstrating in ICU patients that duration of mechanical ventilation causes a logarithmic decline in diaphragm force.
32. Jaber S, Petrof BJ, Jung B, et al. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 2010; (in press). Study demonstrating progressive decrease in diaphragm force in ICU patient.
33. Hussain SN, Mofarrahi M, Sigala I, et al. Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med 2010; (in press).
34. Voisin L, Breuille D, Combaret L, et al. Muscle wasting in a rat model of longlasting sepsis results from the activation of lysosomal, Ca2+-activated, and ubiquitin-proteasome proteolytic pathways. J Clin Invest 1996;97:1610-1617.
35. Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116. This study shows mortality benefit with the use of muscle relaxant in ARDS which might be caused by improved patient-ventilator synchrony.
36. Petrof BJ, Jaber S, Matecki S. Ventilator-induced diaphragmatic dysfunction. Curr Opin Crit Care 2010;16:19-25.
37. Jung B, Constantin JM, Rossel N, et al. Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction in piglet: an in vivo and in vitro study. Anesthesiology 2010;112:1435-1443.
38. Sassoon CS, Zhu E, Caiozzo VJ. Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;170:626-632. (Pubitemid 39202204)