ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction

Lymphatic Research and Biology

Volumn 9, Issue 1, 2011, Pages 3-11

  Breslin, Jerome W ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYCLIC AMP; HISTAMINE; MYOSIN LIGHT CHAIN KINASE; RHO KINASE; THROMBIN;

ARTICLE; BLOOD VESSEL PERMEABILITY; CELL FUNCTION; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROVASCULAR ENDOTHELIAL CELL; MUSCLE FIBER CONTRACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ADULT; AMIDES; AZEPINES; CAPILLARY PERMEABILITY; CELLS, CULTURED; CYCLIC AMP; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HISTAMINE; HUMANS; MYOSIN-LIGHT-CHAIN KINASE; NAPHTHALENES; PYRIDINES; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; THROMBIN;

EID: 79952979711     PISSN: 15396851     EISSN: None     Source Type: Journal    
DOI: 10.1089/lrb.2010.0016     Document Type: Article

References (45)

1. Rockson SG. The unique biology of lymphatic edema. Lymphat Res Biol 2009;7:97-100.
2. Granger DN, Korthuis RJ, Kvietys PR, Tso P. Intestinal microvascular exchange during lipid absorption. Am J Physiol 1988;255:G690-695.
3. Lynch PM, Delano FA, Schmid-Schonbein GW. The primary valves in the initial lymphatics during inflammation. Lymphat Res Biol 2007;5:3-10. (Pubitemid 46753894)
4. Schmid-Schonbein GW. The second valve system in lymphatics. Lymphat Res Biol 2003;1:25-29; discussion 29-31.
5. Zawieja DC. Contractile physiology of lymphatics. Lymphat Res Biol 2009;7:87-96.
6. Adair TH, Moffatt DS, Paulsen AW, Guyton AC. Quantitation of changes in lymph protein concentration during lymph node transit. Am J Physiol 1982;243:H351-359. (Pubitemid 12000002)
7. Brace RA, Taylor AE, Guyton AC. Time course of lymph protein concentration in the dog. Microvasc Res 1977;14: 243-249. (Pubitemid 8254440)
8. Scallan JP, Huxley VH. In vivo determination of collecting lymphatic vessel permeability to albumin: A role for lymphatics in exchange. J Physiol 2010;588:243-254.
9. Breslin JW, Kurtz KM. Lymphatic endothelial cells adapt their barrier function in response to changes in shear stress. Lymphat Res Biol 2009;7:229-237.
10. Breslin JW, Yuan SY, Wu MH. VEGF-C alters barrier function of cultured lymphatic endothelial cells through a VEGFR-3-dependent mechanism. Lymphat Res Biol 2007;5: 105-113. (Pubitemid 47585359)
11. Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev 2007;21:2422-2432. (Pubitemid 47529372)
12. Duran WN, Sanchez FA, Breslin JW. Microcirculatory Exchange Function. In: RF Tuma, WN Duran, K Ley, eds. Handbook of Physiology: Microcirculation. 2nd ed. San Diego, CA: Academic Press-Elsevier; 2008:81-124.
13. Moy AB, Van Engelenhoven J, Bodmer J, Kamath J, Keese C, Giaever I, Shasby S, Shasby DM. Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces. J Clin Invest 1996;97:1020-1027. (Pubitemid 26070582)
14. Waschke J, Drenckhahn D, Adamson RH, Barth H, Curry FE. cAMP protects endothelial barrier functions by preventing Rac-1 inhibition. Am J Physiol Heart Circ Physiol 2004;287:H2427-2433. (Pubitemid 39557111)
15. He P, Zeng M, Curry FE. Dominant role of cAMP in regulation of microvessel permeability. Am J Physiol Heart Circ Physiol 2000;278:H1124-1133. (Pubitemid 30235488)
16. Price GM, Chrobak KM, Tien J. Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes. Microvasc Res 2008;76:46-51.
17. Garcia JG, Davis HW, Patterson CE. Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation. J Cell Physiol 1995; 163:510-522.
18. Yuan SY, Wu MH, Ustinova EE, Guo M, Tinsley JH, De Lanerolle P, Xu W. Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage. Circ Res 2002;90:1214-1221. (Pubitemid 34786907)
19. Breslin JW, Sun H, Xu W, Rodarte C, Moy AB, Wu MH, Yuan SY. Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage. Am J Physiol Heart Circ Physiol 2006;290:H741- 750.
20. Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev 2006;86:279-367.
21. Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001;91:1487-1500. (Pubitemid 32900340)
22. Huang Q, Yuan Y. Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am J Physiol 1997;273:H2442-2451.
23. Guo M, Breslin JW, Wu MH, Gottardi CJ, Yuan SY. VEcadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am J Physiol Cell Physiol 2008;294:C977-984. (Pubitemid 351507915)
24. Fox JL, von der Weid PY. Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery. Br J Pharmacol 2002;136:1210-1218. (Pubitemid 34970074)
25. Plaku KJ, von der Weid PY. Mast cell degranulation alters lymphatic contractile activity through action of histamine. Microcirculation 2006;13:219-227.
26. Malik AB, Lo SK. Thrombin-endothelial interactions: Role in lung vascular permeability. Mol Aspects Med 1985;8:515-554. (Pubitemid 17211058)
27. Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY. Molecular mechanisms of endothelial hyperpermeability: Implications in inflammation. Expert Rev Mol Med 2009; 11:e19.
28. Tiruppathi C, Ahmmed GU, Vogel SM, Malik AB. Ca2+ signaling, TRP channels, and endothelial permeability. Microcirculation 2006;13:693-7-08. (Pubitemid 44688424)
29. van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW. Activation of RhoA by thrombin in endothelial hyperpermeability: Role of Rho kinase and protein tyrosine kinases. Circ Res 2000;87: 335-340. (Pubitemid 30655976)
30. Moy AB, Blackwell K, Kamath A. Differential effects of histamine and thrombin on endothelial barrier function through actin-myosin tension. Am J Physiol Heart Circ Physiol 2002;282:H21-29. (Pubitemid 34654130)
31. Birukova AA, Burdette D, Moldobaeva N, Xing J, Fu P, Birukov KG. Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP. Microvasc Res 2009:79:128-138.
32. Tiruppathi C, Malik AB, Del Vecchio PJ, Keese CR, Giaever I. Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci USA 1992;89:7919-7923.
33. Yuan Y, Huang Q, Wu HM. Myosin light chain phosphorylation: Modulation of basal and agonist-stimulated venular permeability. Am J Physiol 1997;272:H1437-1443.
34. Breslin JW, Yuan SY. Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability. Am J Physiol Heart Circ Physiol 2004;286:H1057-1062. (Pubitemid 38248621)
35. Yuan SY. Signal transduction pathways in enhanced microvascular permeability. Microcirculation 2000;7:395-403.
36. Moy AB, Winter M, Kamath A, Blackwell K, Reyes G, Giaever I, Keese C, Shasby DM. Histamine alters endothelial barrier function at cell-cell and cell-matrix sites. Am J Physiol Lung Cell Mol Physiol 2000;278:L888-898. (Pubitemid 30351043)
37. Birukova AA, Adyshev D, Gorshkov B, Bokoch GM, Birukov KG. Verin AD. GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2006;290:L540-548. (Pubitemid 43725099)
38. Moy AB, Bodmer JE, Blackwell K, Shasby S, Shasby DM. cAMP protects endothelial barrier function independent of inhibiting MLC20-dependent tension development. Am J Physiol 1998;274:L1024-1029.
39. Matsumura F, Hartshorne DJ. Myosin phosphatase target subunit: Many roles in cell function. Biochem Biophys Res Commun 2008;369:149-156.
40. Ferguson MK, Shahinian HK, Michelassi F. Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. J Surg Res 1988;44:172-177. (Pubitemid 18064230)
41. Watanabe N, Kawai Y, Ohhashi T. Dual effects of histamine on spontaneous activity in isolated bovine mesenteric lymphatics. Microvasc Res 1988;36:239-249. (Pubitemid 19000560)
42. Nakamura K, Radhakrishnan K, Wong YM, Rockson SG. Anti-inflammatory pharmacotherapy with ketoprofen ameliorates experimental lymphatic vascular insufficiency in mice. PLoS One 2009;4:e8380.
43. van Nieuw Amerongen GP, Draijer R, Vermeer MA, van HinsberghVW. Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: Role of protein kinases, calcium, and RhoA. Circ Res 1998;83:1115-1123. (Pubitemid 28533520)
44. Wojciak-Stothard B, Potempa S, Eichholtz T, Ridley AJ. Rho and Rac but not Cdc42 regulate endothelial cell permeability. J Cell Sci 2001;114:1343-1355. (Pubitemid 32409470)
45. Carbajal JM, Gratrix ML, Yu CH, Schaeffer RC, Jr. ROCK mediates thrombin's endothelial barrier dysfunction. Am J Physiol Cell Physiol 2000;279:C195-204. (Pubitemid 30616634)