Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: A patent perspective

Expert Opinion on Therapeutic Patents

Volumn 21, Issue 2, 2011, Pages 121-130

  Manalo, Katrina B ^a,b   Choong, Peter F M ^b,c   Becerra, S Patricia ^d   Dass, Crispin R ^e  

^a Master of Science   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d NATIONAL EYE INSTITUTE   (United States)

^e VICTORIA UNIVERSITY   (Australia)

Author keywords

Angiogenesis; cancer; drug; patent; PEDF; PEDF receptor; therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CHITOSAN; FAS LIGAND; GROWTH FACTOR RECEPTOR; LAMININ RECEPTOR; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIGMENT EPITHELIUM DERIVED FACTOR; PLASMINOGEN ACTIVATOR INHIBITOR 2; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARDIOVASCULAR DISEASE; DIABETIC RETINOPATHY; HUMAN; LUNG CANCER; MELANOMA; MICROBUBBLE; NONHUMAN; OBESITY; OSTEOSARCOMA; PANCREAS CANCER; PATENT; PROSTATE CANCER; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SUBRETINAL NEOVASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; EYE PROTEINS; GENE THERAPY; HUMANS; NEOPLASMS; NERVE GROWTH FACTORS; PATENTS AS TOPIC; RECEPTORS, NEUROPEPTIDE; SERPINS;

EID: 79952953238     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.2011.545347     Document Type: Article

References (49)

1. Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. J Biol Chem 1995;270:25992-9 . One of the first papers showing the structure and function of PEDF.
2. Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Opthalmol Vis Sci 1989;30:1700-7 . A paper demonstrating the discovery of the neurotrophic role of PEDF in differentiating retinoblastoma cells. (Pubitemid 19214990)
3. Tombran-Tink J, Chader GG, Johnson LV. PEDF: A pigment epitherlium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991;53(3):411-14 . A paper demonstrating the neurotrophic role of PEDF.
4. Cao W, Tombran-Tink J, Elias R, et al In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Opthalmol Vis Sci 2001;42:1646-52 A research paper demonstrating the neuroprotective role of PEDF in the eye. (Pubitemid 32520760)
5. Bilak MM, Corse AM, Bilak SR, et al Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol 1999;58(7):719-28 A research paper demonstrating the neuroprotective role of PEDF in neurons. (Pubitemid 29328501)
6. Araki T, Taniwaki T, Becerra SP, et al Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res 1998;53(1):7-15 A research paper demonstrating the neuroprotective role of PEDF towards cerebellar granule cells. (Pubitemid 28308977)
7. Cayouette M, Smith SB, Becerra SP, Gravel C. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 1999;6(6):523-32 A research paper demonstrating the neuroprotective role of PEDF in the eye. (Pubitemid 30036622)
8. Dawson DW, Volpert OV, Gillis P, et al Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science 1999;285:245-8 . A paper showing the antiangiogenic role of PEDF. (Pubitemid 29329995)
9. Maik-Rachline G, Seger R. Variable phosphorylation states of pigment-epithelim-derived factor differentially regulate its function. Blood 2006;107:2745-52 . A research paper demonstrating the different phosphorylation states of PEDF affecting PEDF's role as a neurotrophic agent or an antiangiogenic agent.
10. Dass CR, Ek ET, Choong PF. PEDF as an emerging therapeutic candidate for osteosarcoma. Curr Cancer Drug Targets 2008;8(8):683-90 . A literature review summarising the antiangiogenic and antitumorigenic property of PEDF as a drug candidate against osteosarcoma.
11. Broadhead ML, Dass CR, Choong PF. In vitro and in vivo biological activity of PEDF against a range of tumors. Expert Opin Ther Targets 2009;13(12):1429-38 . A literature review summarising all the research papers which reported the therapeutic role of PEDF in different cancer cell lines.
12. Yamagishi S, Imaizumi T, Shimizu H, Abe R. Method for preventing or treating malignant melanoma. US20050222031; 2005 . A patent paper showing the therapeutic role of PEDF against melanoma.
13. Yamagishi S, Imaizumi T. Method for preventing or treating osteosarcoma. US20060122112; 2006 . A patent paper showing the therapeutic role of PEDF against osteosarcoma.
14. Kovesdi I, Brough DE, McVey DL, Wei L. Viral vector encoding pigment epithelium-derived factor. US20050101018; 2005 . A patent paper showing the experimental methods behind recombinant gene delivery vectors of PEDF.
15. Manning WC, Dwarki VJ, Rendahl K, et al Use of recombinant gene delivery vectors for treating or preventing diseases of the eye. US6943153; 2005 . A patent paper showing the experimental methods behind recombinant gene delivery vectors of PEDF in the eye.
16. Bouck NP, Dawson DW, Gillis PR, et al Methods and compositions for inhibiting angiogenesis. US7105496; 2006 . A patent paper showing the experimental methods behind the investigation of the antiangiogenic factor of PEDF.
17. Becerra SP, Notari L, Laborda J, Escribano-Martinez J. PEDF-R receptor and uses. US20090162363; 2009 . A patent paper showing the use and function of PEDF receptors.
18. Gordon MS, Mendelson DS, Kato G. Tumor angiogenesis and novel antiangiogenic strategies. Int J Cancer 2010;126(8):1777-87 . A literature review paper summarising the mechanism behind tumorigenesis and a list of the antiangiogenic factors currently under investigation in clinical trials.
19. Folkman J. Fighting cancer by attacking its blood supply. Sci Am 1996;275(3):150-4 . The first paper published proposing the role of angiogenesis as an important factor in cancer cell growth and survival.
20. Bouck N. PEDF: Anti-angiogenic guardian of ocular function. Trends Mol Med 2002;8:330-4 . A literature review paper summarising PEDF's antiangiogenic role in the eye. (Pubitemid 34733386)
21. Volz K, Filleur S, Volpert O, Zaichuk T. Anti-angiogenic fragments of pigment epithelium-derived factor (PEDF). US20090118191; 2009 . A patent paper showing the use and function of PEDF peptides.
22. Seger R, Maik-Rachline G. Variants of pigment epithelium derived factor and uses thereof. US20090269320; 2009 . A patent paper showing the use and function of PEDF peptides.
23. Ho TC, Chen SL, Yang YC, et al PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilican vein endothelial cells. Cardiovasc Res 2007;76:213-23 . A paper showing the apoptotic pathway activated by PEDF.
24. Gao D, Nolan D, McDonnell K, et al Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Biochim Biophys Acta 2009;1796:33-40 A paper showing the involvement of bone marrow-derived endothelial cells in tumorigenesis.
25. Ek ET, Dass CR, Contreras KG, Choong PF. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Clin Exp Metastasis 2007;24:93-106 A research paper showing the therapeutic role of PEDF against osteosarcoma. (Pubitemid 46669247)
26. Ek ET, Dass CR, Contreras KG, Choong PF. PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma. J Orthop Res 2007;25:1671-80 A paper showing the therapeutic effects of PEDF peptides against osteosarcoma. (Pubitemid 350293816)
27. Ta HT, Dass CR, Larson I, et al A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma. Biomaterials 2009;30(21):3605-13 . A paper showing the use of chitosan microparticles in combination with a hydrogel in PEDF treatment on bone.
28. Broadhead ML, Dass CR, Choong PF. Cancer cell apoptotic pathways mediated by PEDF: Prospects for therapy. Trends Mol Med 2009;15(10):461-7 . A literature review summarising all the research papers which reported the apoptotic role of PEDF.
29. Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ. Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol 2003;195:12-20 . A paper showing one of the mechanisms behind PEDF's role in inhibiting proliferation and cell cycling. (Pubitemid 36292755)
30. Zhou XY, Liao Q, Pu YM, et al Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization. Chin Med J (Engl) 2009;122(22):2711-17 . A paper showing the use of ultrasound-mediated microbubble technique in PEDF treatment.
31. Dass CR, Contreras K, Dunstan DE, Choong PF. Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. Biomaterials 2007;28:3026-33 . A paper showing the use of chitosan microparticles in PEDF treatment on bone. (Pubitemid 46560874)
32. Alberdi E, Aymerich MS, Becerra SP. Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem 1999;274(44):31605-12 . One of the first papers to report the discovery of a PEDF receptor.
33. Valnickova Z, Petersen SV, Nielsen SB, et al Heparin binding induces a conformational change in pigment epithelium-derived factor. J Biol Chem 2007;282:6661-7 A paper showing the mechanism of PEDF to induce a conformational change in its structure. (Pubitemid 47100837)
34. Alberdi EM, Weldon JE, Becerra SP. Glycosaminoglycans in human retinoblastoma cells: Hepara sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions. BMC Biochem 2003;19(4):1 A paper showing the role of glycosaminoglycans in the conformational change exerted by PEDF
35. Filleur S, Nelius T, de Riese W, Kennedy RC. Characterization of PEDF: A multi-functional serpin family protein. J Cellular Biochem 2009;106:769-75 . A review summarising PEDF's biological role and the discovery of two PEDF receptors.
36. Bernard A, Gao-Li J, Franco CA, et al Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor. J Biol Chem 2009;284(16):10480-90 . A research paper showing the antiangiogenic effects of PEDF on its binding to the laminin receptor.
37. Notari L, Baladron V, Aroca-Aguilar JD, et al Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 2006;49:38022-37 . One of the first papers published demonstrating the identification, structure and localisation of the PNPLA2 PEDF receptor and its affinity on PEDF. (Pubitemid 46042106)
38. Subramanian P, Notario PM, Becerra SP. Pigment epithelium-derived factor receptor (PEDF-R): A plasma membrane-linked phospholipase with PEDF binding affinity. Adv Exp Med Biol 2010;664:29-37 . A paper showing the biological role of the PNPLA2 PEDF receptor on PEDF binding.
39. Konson A, Pradeep S, D'Acunto CW, et al Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem. 2010; In press . A recent paper and one of the first research papers which showed the molecular pathways associated with PEDF binding to the laminin receptor.
40. Yang J, Duh EJ, Caldwell RB, et al Antipermeability function of PEDF involves blockade of the MAP kinase/ GSK/beta-catenin signalling pathway and uPAR expression. Invest Opthalmol Vis Sci 2010:51(6):3273-80 . A recent research paper showing the molecular pathways activated by PEDF.
41. Zhang SX, Wang JJ, Gao G, et al Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF- VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol 2006:37(1):1-12 . A research papers which showed PEDF's inhibitory role against VEGFR and its receptor. (Pubitemid 44288601)
42. Crowe S, Wu LE, Economou C, et al Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab 2009:10(1):40-7 A research paper showing the biological role of PEDF in obesity.
43. Tombran-Tink J. The neuroprotective and angiogenesis inhibitory serpin, PEDF: New insights into phylogeny, function, and signalling. Front Biosci 2005;10:2131-49 . An excellent review summarising the structure, function and localisation of PEDF as a neurotrophic and antiangiogenic factor. (Pubitemid 40905288)
44. Rychli K, Kaun C, Hohensinner PJ, et al The anti-angiogenic factor PEDF if present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts. J Cell Mol Med 2010;14(1-2):198-205 A research paper showing the biological role of PEDF and its localisation in the heart.
45. Chung C, Doll JA, Gattu AK, et al Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J Hepatol 2008;48(3):471-8 A research paper showing the biological role of PEDF and its localisation in the liver.
46. Cheugh L, Au S, Cheung A, et al Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology 2006;147(9):4179-91 A research paper showing the biological role of PEDF and its localisation in the female reproductive system. (Pubitemid 44268369)
47. Grayhack JT, Smith ND, Ilio K, et al Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. J Urol 2004;171(1):434-38 A research paper showing the biological role of PEDF and its localisation in the male reproductive system. (Pubitemid 37549205)
48. Quan G, Ojaimi J, Li Y, et al Localization of pigment epithelim-derived factor in growing mouse bone. Calcif Tissue Int 2005;76:146-53 A research paper showing the biological role of PEDF and its localisation in bone. (Pubitemid 40684962)
49. Notari L, Arakaki N, Mueller D, et al Pigment epithelium-derived factor binds to cell-surface F(1)-ATP synthase. FEBS J 2010;277(9):2192-205 . A recent research paper showing a possible new PEDF receptor.