-
1
-
-
79952983003
-
-
NICE. Rheumatoid Arthritis Consultation Document [Internet]. Available at, Accessed January 26
-
NICE. Rheumatoid Arthritis Consultation Document [Internet]. Available at: www.nice.org.uk. Accessed January 26, 2010.
-
(2010)
-
-
-
2
-
-
43649104094
-
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis
-
Ohsugi Y, Kishimoto T. The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2008;8:669-681.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 669-681
-
-
Ohsugi, Y.1
Kishimoto, T.2
-
3
-
-
36048991069
-
Recent advances in immunopathophysiology of interleukin-6: An innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases
-
Ohsugi Y. Recent advances in immunopathophysiology of interleukin-6: An innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol Pharm Bull. 2007;30:2001-2006.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 2001-2006
-
-
Ohsugi, Y.1
-
4
-
-
0027502201
-
Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
-
Sato K, Tsuchiya M, Saldanha J, et al. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res. 1993;53:851-856.
-
(1993)
Cancer Res
, vol.53
, pp. 851-856
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
-
5
-
-
23644442893
-
Tocilizumab inhibits signal transduction mediated by both mIL-6R and soluble interleukin-6 receptor, but not by the receptors of other members of IL-6 cytokine family
-
Mihara M, Kasutani K, Okazaki M, et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and soluble interleukin-6 receptor, but not by the receptors of other members of IL-6 cytokine family. Int Immunopharmacol. 2005;5:1731-1740.
-
(2005)
Int Immunopharmacol
, vol.5
, pp. 1731-1740
-
-
Mihara, M.1
Kasutani, K.2
Okazaki, M.3
-
6
-
-
60149105639
-
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
-
Nishimoto N, Miyasaka N, Yamamoto K, et al. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol. 2009;19: 12-19.
-
(2009)
Mod Rheumatol
, vol.19
, pp. 12-19
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
-
7
-
-
34447300492
-
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised, controlled trial of tocilizumab
-
Nishimoto N, Hashimoto J, Miyasaka N, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised, controlled trial of tocilizumab. Ann Rheum Dis. 2007;66:1162-1167.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 1162-1167
-
-
Nishimoto, N.1
Hashimoto, J.2
Miyasaka, N.3
-
8
-
-
73449118587
-
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
-
Jones G, Sebba A, Gu J, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study. Ann Rheum Dis. 2010; 69:88-96.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 88-96
-
-
Jones, G.1
Sebba, A.2
Gu, J.3
-
9
-
-
54949150604
-
Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: Tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
-
Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: Tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968-2980.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2968-2980
-
-
Genovese, M.C.1
McKay, J.D.2
Nasonov, E.L.3
-
10
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet. 2008;371:987-997.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
11
-
-
79952280715
-
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate at 1 year: The LITHE study
-
November 19. [Epub ahead of print]
-
Kremer JL, Blanco R, Brzosko M, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate at 1 year: The LITHE study. Arthritis Rheum. 2010; November 19. [Epub ahead of print].
-
(2010)
Arthritis Rheum
-
-
Kremer, J.L.1
Blanco, R.2
Brzosko, M.3
-
12
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis. 2008;67:1516-1523.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
-
13
-
-
79960128977
-
Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: Results from a retrospective study (REACTION study)
-
October 16. [Epub ahead of print]
-
Yamanaka H, Tanaka Y, Inoue E, et al. Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: Results from a retrospective study (REACTION study). Mod Rheumatol. 2010; October 16. [Epub ahead of print].
-
(2010)
Mod Rheumatol
-
-
Yamanaka, H.1
Tanaka, Y.2
Inoue, E.3
-
14
-
-
77954426599
-
Clinical efficacy of tocilizumab in patients with active rheumatoid arthritis in real clinical practice
-
Hirabayashi Y, Ishii T, Harigae H. Clinical efficacy of tocilizumab in patients with active rheumatoid arthritis in real clinical practice. Rheumatol Int. 2010;30:1041-1048.
-
(2010)
Rheumatol Int
, vol.30
, pp. 1041-1048
-
-
Hirabayashi, Y.1
Ishii, T.2
Harigae, H.3
-
15
-
-
70349402169
-
Long-term safety and efficacy of tocilizumab, an antiinterleukin- 6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
-
Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an antiinterleukin- 6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis. 2009;68: 1580-1584.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1580-1584
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
Kawai, S.4
Takeuchi, T.5
Azuma, J.6
-
16
-
-
78650514889
-
Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab: Subanalysis of the SATORI study
-
Nishimoto N, Takagi N. Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab: Subanalysis of the SATORI study. Mod Rheumatol. 2010;20:539-547.
-
(2010)
Mod Rheumatol
, vol.20
, pp. 539-547
-
-
Nishimoto, N.1
Takagi, N.2
-
17
-
-
70350028295
-
Efficacy of tocilizumab and evaluation of clinical remission as determined by CDAI and MMP-3 level
-
Funahashi K, Koyano S, Miura T, Hagiwara T, Okuda K, Matsubara T. Efficacy of tocilizumab and evaluation of clinical remission as determined by CDAI and MMP-3 level. Mod Rheumatol. 2009;19: 507-512.
-
(2009)
Mod Rheumatol
, vol.19
, pp. 507-512
-
-
Funahashi, K.1
Koyano, S.2
Miura, T.3
Hagiwara, T.4
Okuda, K.5
Matsubara, T.6
-
18
-
-
78650764821
-
Interleukin-6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: The role of acute-phase reactants
-
Smolen JS, Aletaha D. Interleukin-6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: The role of acute-phase reactants. Arthritis Rheum. 2011;63:43-52.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 43-52
-
-
Smolen, J.S.1
Aletaha, D.2
-
19
-
-
77956646068
-
Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: Meta-analysis of six initial trials and five long-term extensions
-
Nishimoto N, Ito K, Takagi N. Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: Meta-analysis of six initial trials and five long-term extensions. Mod Rheumatol. 2010;20:222-232.
-
(2010)
Mod Rheumatol
, vol.20
, pp. 222-232
-
-
Nishimoto, N.1
Ito, K.2
Takagi, N.3
-
20
-
-
78650427963
-
Gastrointestinal safety in patients with rheumatoid arthritis treated with tocilizumab: Data from Roche clinical trials
-
Abstr 1613
-
Van Vollenhoven RF, Keystone EC, Furie R, Blesch A, Wang C, Curtis JR. Gastrointestinal safety in patients with rheumatoid arthritis treated with tocilizumab: Data from Roche clinical trials. Abstr 1613. Arthritis Rheum. 2009;60 Suppl:S602.
-
(2009)
Arthritis Rheum
, vol.60
, Issue.SUPPL.
-
-
van Vollenhoven, R.F.1
Keystone, E.C.2
Furie, R.3
Blesch, A.4
Wang, C.5
Curtis, J.R.6
-
21
-
-
33749363027
-
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
Maini RN, Taylor PC, Szechinski J, et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 2006;54:2817-2829.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
-
22
-
-
64949203166
-
Tocilizumab: A review of its use in the management of rheumatoid arthritis
-
Oldfield V, Dhillon S, Plosker GL. Tocilizumab: A review of its use in the management of rheumatoid arthritis. Drugs. 2009;69:609-632.
-
(2009)
Drugs
, vol.69
, pp. 609-632
-
-
Oldfield, V.1
Dhillon, S.2
Plosker, G.L.3
-
23
-
-
79952906538
-
Safety of tocilizumab in patients with rheumatoid arthritis: Analysis of median of 3.1 years of treatment in long-term extension studies
-
Rome, Italy, June 16-19
-
Van Vollenhoven RF, Scali JJ, Curtis JR, et al. Safety of tocilizumab in patients with rheumatoid arthritis: Analysis of median of 3.1 years of treatment in long-term extension studies. Poster SAT0172 presented at the European League against Rheumatism Annual European Congress of Rheumatology, Rome, Italy, June 16-19, 2010.
-
(2010)
Poster SAT0172 Presented At the European League Against Rheumatism Annual European Congress of Rheumatology
-
-
van Vollenhoven, R.F.1
Scali, J.J.2
Curtis, J.R.3
-
24
-
-
0027978341
-
Effects of recombinant human interleukin-6 in cancer patients: A phase I-II study
-
Van Gameren MM, Willemse PH, Mulder NH, et al. Effects of recombinant human interleukin-6 in cancer patients: A phase I-II study. Blood. 1994;84:1434-1441.
-
(1994)
Blood
, vol.84
, pp. 1434-1441
-
-
van Gameren, M.M.1
Willemse, P.H.2
Mulder, N.H.3
-
25
-
-
0027461967
-
Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies
-
Weber J, Yang JC, Topalian SL, et al. Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J Clin Oncol. 1993;11:499-506.
-
(1993)
J Clin Oncol
, vol.11
, pp. 499-506
-
-
Weber, J.1
Yang, J.C.2
Topalian, S.L.3
-
26
-
-
13444302254
-
Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis
-
Vis M, Nurmohamed MT, Wolbink G, et al. Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis. J Rheumatol. 2005;32:252-255.
-
(2005)
J Rheumatol
, vol.32
, pp. 252-255
-
-
Vis, M.1
Nurmohamed, M.T.2
Wolbink, G.3
-
27
-
-
20044362604
-
Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: Serum levels and relationship to inflammation
-
Dursunoglu D, Evrengül H, Polat B, et al. Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: Serum levels and relationship to inflammation. Rheumatol Int. 2005;25:241-245.
-
(2005)
Rheumatol Int
, vol.25
, pp. 241-245
-
-
Dursunoglu, D.1
Evrengül, H.2
Polat, B.3
-
28
-
-
64949111191
-
Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions
-
Choy E, Sattar N. Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions. Ann Rheum Dis. 2009;68: 460-469.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 460-469
-
-
Choy, E.1
Sattar, N.2
-
29
-
-
77950335656
-
Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low- density lipoprotein receptor
-
Hashizume M, Yoshida H, Koike N, Suzuki M, Mihara M. Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low- density lipoprotein receptor. Ann Rheum Dis. 2010; 69:741-746.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 741-746
-
-
Hashizume, M.1
Yoshida, H.2
Koike, N.3
Suzuki, M.4
Mihara, M.5
-
30
-
-
13244252637
-
Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis
-
Popa C, Netea MG, Radstake T, et al. Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis. Ann Rheum Dis. 2005;64:303-305.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 303-305
-
-
Popa, C.1
Netea, M.G.2
Radstake, T.3
-
31
-
-
0023942493
-
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
-
Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988;31:784-788.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 784-788
-
-
Houssiau, F.A.1
Devogelaer, J.P.2
van Damme, J.3
de Deuxchaisnes, C.N.4
van Snick, J.5
-
32
-
-
0027518860
-
Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
-
Madhok R, Crilly A, Watson J, Capell HA. Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis. 1993;52:232-234.
-
(1993)
Ann Rheum Dis
, vol.52
, pp. 232-234
-
-
Madhok, R.1
Crilly, A.2
Watson, J.3
Capell, H.A.4
-
34
-
-
33645565975
-
Angiogenesis in rheumatoid arthritis
-
Maruotti N, Cantatore FP, Crivellato E, Vacca A, Ribatti D. Angiogenesis in rheumatoid arthritis. Histol Histopathol. 2006;21:557-566.
-
(2006)
Histol Histopathol
, vol.21
, pp. 557-566
-
-
Maruotti, N.1
Cantatore, F.P.2
Crivellato, E.3
Vacca, A.4
Ribatti, D.5
-
35
-
-
0038798085
-
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
-
Nakahara H, Song J, Sugimoto M, et al. Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum. 2003;48:1521-1529.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1521-1529
-
-
Nakahara, H.1
Song, J.2
Sugimoto, M.3
-
36
-
-
69049109765
-
IL-6/soluble interleukin- 6 receptor trans-signalling, but not TNF-alpha induced angiogenesis in a HUVEC and synovial cell co-culture system
-
Hashizume M, Hayakawa N, Suzuki M, Mihara M. IL-6/soluble interleukin- 6 receptor trans-signalling, but not TNF-alpha induced angiogenesis in a HUVEC and synovial cell co-culture system. Rheumatol Int. 2009;29:1449-1454.
-
(2009)
Rheumatol Int
, vol.29
, pp. 1449-1454
-
-
Hashizume, M.1
Hayakawa, N.2
Suzuki, M.3
Mihara, M.4
-
37
-
-
45749149999
-
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis
-
Uchiyama Y, Yorozu K, Hashizume M, Moriya Y, Mihara M. Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. Biol Pharm Bull. 2008;31:1159-1163.
-
(2008)
Biol Pharm Bull
, vol.31
, pp. 1159-1163
-
-
Uchiyama, Y.1
Yorozu, K.2
Hashizume, M.3
Moriya, Y.4
Mihara, M.5
-
38
-
-
73649103466
-
Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: Effect on the expression of chemokine and adhesion molecule
-
Suzuki M, Hashizume M, Yoshida H, Mihara M. Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: Effect on the expression of chemokine and adhesion molecule. Rheumatol Int. 2010;30:309-315.
-
(2010)
Rheumatol Int
, vol.30
, pp. 309-315
-
-
Suzuki, M.1
Hashizume, M.2
Yoshida, H.3
Mihara, M.4
-
39
-
-
0029060421
-
Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor
-
Mihara M, Moriya Y, Kishimoto T, Ohsugi Y. Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor. Br J Rheumatol. 1995;34:321-325.
-
(1995)
Br J Rheumatol
, vol.34
, pp. 321-325
-
-
Mihara, M.1
Moriya, Y.2
Kishimoto, T.3
Ohsugi, Y.4
-
40
-
-
54449101331
-
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17
-
Hashizume M, Hayakawa N, Mihara M. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. Rheumatology (Oxford). 2008;47:1635-1640.
-
(2008)
Rheumatology (Oxford)
, vol.47
, pp. 1635-1640
-
-
Hashizume, M.1
Hayakawa, N.2
Mihara, M.3
-
41
-
-
79952928539
-
The effect of short term treatment of anti-IL-6 receptor antibody tocilizumab on signs and symptoms and synovial inflammation in patients with active rheumatoid arthritis
-
Sagawa A. The effect of short term treatment of anti-IL-6 receptor antibody tocilizumab on signs and symptoms and synovial inflammation in patients with active rheumatoid arthritis. Ann Rheum Dis. 2010;69 Suppl 3:539.
-
(2010)
Ann Rheum Dis
, vol.69
, Issue.SUPPL. 3
, pp. 539
-
-
Sagawa, A.1
-
42
-
-
0029892275
-
Bone resorption by tartrate-resistant acid phosphatase-positive multinuclear cells isolated from rheumatoid synovium
-
Fujikawa Y, Shingu M, Torisu T, Itonaga I, Masumi S. Bone resorption by tartrate-resistant acid phosphatase-positive multinuclear cells isolated from rheumatoid synovium. Br J Rheumatol. 1996;35: 213-217.
-
(1996)
Br J Rheumatol
, vol.35
, pp. 213-217
-
-
Fujikawa, Y.1
Shingu, M.2
Torisu, T.3
Itonaga, I.4
Masumi, S.5
-
43
-
-
0034122050
-
Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
-
Gravallese EM, Manning C, Tsay A, et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 2000;43:250-258.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 250-258
-
-
Gravallese, E.M.1
Manning, C.2
Tsay, A.3
-
44
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998; 93:165-176.
-
(1998)
Cell
, vol.93
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.L.3
-
45
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315-323.
-
(1999)
Nature
, vol.397
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
-
46
-
-
0034121039
-
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
-
Takayanagi H, Iizuka H, Juji T, et al. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2000;43:259-269.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 259-269
-
-
Takayanagi, H.1
Iizuka, H.2
Juji, T.3
-
47
-
-
43949139580
-
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, doubleblind, placebo-controlled, phase II clinical trial
-
Cohen SB, Dore RK, Lane NE, et al. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, doubleblind, placebo-controlled, phase II clinical trial. Arthritis Rheum. 2008; 58:1299-1309.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1299-1309
-
-
Cohen, S.B.1
Dore, R.K.2
Lane, N.E.3
-
48
-
-
70349768147
-
Desirable effect of combination therapy with high molecular weight hyaluronate and nonsteroidal anti-inflammatory drugs on MMP production
-
Hashizume M, Mihara M. Desirable effect of combination therapy with high molecular weight hyaluronate and nonsteroidal anti-inflammatory drugs on MMP production. Osteoarth Cartil. 2009;17:1513-1518.
-
(2009)
Osteoarth Cartil
, vol.17
, pp. 1513-1518
-
-
Hashizume, M.1
Mihara, M.2
-
49
-
-
77954085343
-
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression
-
Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Cytokine. 2010;51:178-183.
-
(2010)
Cytokine
, vol.51
, pp. 178-183
-
-
Suzuki, M.1
Hashizume, M.2
Yoshida, H.3
Shiina, M.4
Mihara, M.5
-
50
-
-
79951958089
-
Humanized antiinterleukin- 6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: Data from the SAMURAI study
-
June 24, [Epub ahead of print]
-
Hashimoto J, Garnero P, van der Heijde D, et al. Humanized antiinterleukin- 6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: Data from the SAMURAI study. Mod Rheumatol. June 24, 2010. [Epub ahead of print].
-
(2010)
Mod Rheumatol
-
-
Hashimoto, J.1
Garnero, P.2
van der Heijde, D.3
-
51
-
-
74849102659
-
Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate
-
Garnero P, Thompson E, Woodworth T, Smolen JS. Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate. Arthritis Rheum. 2010;62:33-43.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 33-43
-
-
Garnero, P.1
Thompson, E.2
Woodworth, T.3
Smolen, J.S.4
-
52
-
-
76649095646
-
Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics
-
Kawashiri SY, Kawakami A, Iwamoto N, et al. Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics. Mod Rheumatol. 2010;20:40-45.
-
(2010)
Mod Rheumatol
, vol.20
, pp. 40-45
-
-
Kawashiri, S.Y.1
Kawakami, A.2
Iwamoto, N.3
-
54
-
-
0023769893
-
Serum immunoreactive erythropoietin in rheumatoid arthritis: Impaired response to anemia
-
Hochberg MC, Arnold CM, Hogans BB, Spivak JL. Serum immunoreactive erythropoietin in rheumatoid arthritis: Impaired response to anemia. Arthritis Rheum. 1988;31:1318-1321.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 1318-1321
-
-
Hochberg, M.C.1
Arnold, C.M.2
Hogans, B.B.3
Spivak, J.L.4
-
55
-
-
0030808921
-
Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease
-
Jongen-Lavrencic M, Peeters HR, Wognum A, Vreugdenhil G, Breedveld FC, Swaak AJ. Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease. J Rheumatol. 1997;24:1504-1509.
-
(1997)
J Rheumatol
, vol.24
, pp. 1504-1509
-
-
Jongen-Lavrencic, M.1
Peeters, H.R.2
Wognum, A.3
Vreugdenhil, G.4
Breedveld, F.C.5
Swaak, A.J.6
-
56
-
-
0032805582
-
Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis
-
Voulgari PV, Kolios G, Papadopoulos GK, Katsaraki A, Seferiadis K, Drosos AA. Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis. Clin Immunol. 1999;92: 153-160.
-
(1999)
Clin Immunol
, vol.92
, pp. 153-160
-
-
Voulgari, P.V.1
Kolios, G.2
Papadopoulos, G.K.3
Katsaraki, A.4
Seferiadis, K.5
Drosos, A.A.6
-
57
-
-
49949152296
-
Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNF alpha
-
Uchiyama Y, Koike N, Mihara M. Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNF alpha. Rheumatol Int. 2008;28:879-883.
-
(2008)
Rheumatol Int
, vol.28
, pp. 879-883
-
-
Uchiyama, Y.1
Koike, N.2
Mihara, M.3
-
58
-
-
0041672570
-
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
-
Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783-788.
-
(2003)
Blood
, vol.102
, pp. 783-788
-
-
Ganz, T.1
-
59
-
-
24744458603
-
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
-
Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005;106: 2196-2199.
-
(2005)
Blood
, vol.106
, pp. 2196-2199
-
-
Rivera, S.1
Nemeth, E.2
Gabayan, V.3
Lopez, M.A.4
Farshidi, D.5
Ganz, T.6
-
60
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
-
61
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
-
62
-
-
77955092647
-
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production
-
Hashizume M, Uchiyama Y, Horai N, Tomosugi N, Mihara M. Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatol Int. 2010;30:917-923.
-
(2010)
Rheumatol Int
, vol.30
, pp. 917-923
-
-
Hashizume, M.1
Uchiyama, Y.2
Horai, N.3
Tomosugi, N.4
Mihara, M.5
-
63
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
64
-
-
40549102753
-
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase
-
Iwanami K, Matsumoto I, Tanaka-Watanabe Y, et al. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum. 2008;58: 754-763.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 754-763
-
-
Iwanami, K.1
Matsumoto, I.2
Tanaka-Watanabe, Y.3
-
65
-
-
57349083145
-
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
-
Fujimoto M, Serada S, Mihara M, et al. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 2008;58:3710-3719.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3710-3719
-
-
Fujimoto, M.1
Serada, S.2
Mihara, M.3
-
66
-
-
78751572960
-
IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis
-
Yoshida H, Hashizume M, Mihara M. IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis. Rheumatol Int. 2011;31:127-131.
-
(2011)
Rheumatol Int
, vol.31
, pp. 127-131
-
-
Yoshida, H.1
Hashizume, M.2
Mihara, M.3
-
67
-
-
58149166804
-
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
-
Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med. 2008;205:2491-2497.
-
(2008)
J Exp Med
, vol.205
, pp. 2491-2497
-
-
Notley, C.A.1
Inglis, J.J.2
Alzabin, S.3
McCann, F.E.4
McNamee, K.E.5
Williams, R.O.6
-
68
-
-
54949139265
-
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
-
Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol. 2008;20:1361-1368.
-
(2008)
Int Immunol
, vol.20
, pp. 1361-1368
-
-
Annunziato, F.1
Cosmi, L.2
Liotta, F.3
Maggi, E.4
Romagnani, S.5
-
69
-
-
44549083419
-
Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis
-
Zhang C, Zhang J, Yang B, Wu C. Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine. 2008;42:345-352.
-
(2008)
Cytokine
, vol.42
, pp. 345-352
-
-
Zhang, C.1
Zhang, J.2
Yang, B.3
Wu, C.4
-
70
-
-
77952743228
-
Strategies after the failure of the first anti-tumor necrosis factor a agent in rheumatoid arthritis
-
Papagoras C, Voulgari CV, Drosos AA. Strategies after the failure of the first anti-tumor necrosis factor a agent in rheumatoid arthritis. Autoimmun Rev. 2010;9:574-582.
-
(2010)
Autoimmun Rev
, vol.9
, pp. 574-582
-
-
Papagoras, C.1
Voulgari, C.V.2
Drosos, A.A.3
-
71
-
-
70449725246
-
Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
-
Radstake TR, Svenson M, Eijsbouts AM, et al. Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis. Ann Rheum Dis. 2009;68:1739-1745.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1739-1745
-
-
Radstake, T.R.1
Svenson, M.2
Eijsbouts, A.M.3
-
72
-
-
33646696885
-
Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
-
Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials. J Am Med Assoc. 2006;295:2275-2285.
-
(2006)
J Am Med Assoc
, vol.295
, pp. 2275-2285
-
-
Bongartz, T.1
Sutton, A.J.2
Sweeting, M.J.3
Buchan, I.4
Matteson, E.L.5
Montori, V.6
-
73
-
-
0036169930
-
Guidelines for the management of rheumatoid arthritis: 2002 update
-
American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
-
American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum. 2002;46:328-346.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 328-346
-
-
-
74
-
-
33749331603
-
Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis
-
Okuda Y, Takasugi K. Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum. 2006;54: 2997-3000.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2997-3000
-
-
Okuda, Y.1
Takasugi, K.2
-
75
-
-
0031833904
-
State of the art and perspectives for the future
-
Husby G. Treatment of amyloidosis and the rheumatologist
-
Husby G. Treatment of amyloidosis and the rheumatologist. State of the art and perspectives for the future. Scand J Rheumatol. 1998;27: 161-165.
-
(1998)
Scand J Rheumatol
, vol.27
, pp. 161-165
-
-
-
76
-
-
0035676529
-
High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors
-
Del Rincón ID, Williams K, Stern MP, Freeman GL, Escalante A. High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum. 2001;44: 2737-2745.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 2737-2745
-
-
del Rincón, I.D.1
Williams, K.2
Stern, M.P.3
Freeman, G.L.4
Escalante, A.5
-
77
-
-
0345743620
-
IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system
-
Hagihara K, Nishikawa T, Isobe T, Song J, Sugamata Y, Yoshizaki K. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system. Biochem Biophys Res Commun. 2004;314:363-369.
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 363-369
-
-
Hagihara, K.1
Nishikawa, T.2
Isobe, T.3
Song, J.4
Sugamata, Y.5
Yoshizaki, K.6
-
78
-
-
77953582922
-
Experience with mycobacterium tuberculosis infection reported in the tocilizumab worldwide RA safety database
-
Van Vollenhoven RF, Nishimoto N, Yamanaka H, et al. Experience with mycobacterium tuberculosis infection reported in the tocilizumab worldwide RA safety database. Ann Rheum Dis. 2009;68 Suppl 3:557.
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.SUPPL. 3
, pp. 557
-
-
van Vollenhoven, R.F.1
Nishimoto, N.2
Yamanaka, H.3
-
79
-
-
77954761056
-
Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigens
-
Ogata A, Mori M, Hashimoto S, et al. Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigens. Mod Rheumatol. 2010;20:130-133.
-
(2010)
Mod Rheumatol
, vol.20
, pp. 130-133
-
-
Ogata, A.1
Mori, M.2
Hashimoto, S.3
-
80
-
-
43649104094
-
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis
-
Ohsugi Y, Kishimoto T. The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2008;8:669-681.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 669-681
-
-
Ohsugi, Y.1
Kishimoto, T.2
|