Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 6, 2008, Pages 1159-1163

  Uchiyama, Yasushi ^a   Yorozu, Keigo ^a   Hashizume, Misato ^a   Moriya, Yoichiro ^a   Mihara, Masahiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Monkey collagen induced arthritis; Therapeutic effect; Tocilizumab

Indexed keywords

ATLIZUMAB; C REACTIVE PROTEIN; COLLAGEN TYPE 2; DRUG ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TOCILIZUMAB ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTHRITIS; ARTICLE; BLOOD CHEMISTRY; BLOOD SAMPLING; CALCULATION; CONTROLLED STUDY; FEMALE; FOOT; HAND JOINT; HISTOPATHOLOGY; INTERPHALANGEAL JOINT; JOINT SWELLING; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; COLLAGEN TYPE II; EDEMA; FEMALE; FOOT; HAND; INTERLEUKIN-6; JOINTS; MACACA FASCICULARIS; NEUTROPHIL INFILTRATION; RECEPTORS, INTERLEUKIN-6;

EID: 45749149999     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1159     Document Type: Article

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