Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 35, Issue 2, 2011, Pages 356-362

  Pivac, Nela ^a   Nikolac, Matea ^a   Nedic, Gordana ^a   Mustapic, Maja ^a   Borovecki, Fran ^b,c   Hajnsek, Sanja ^b   Presecki, Paola ^d   Pavlovic, Mladen ^e   Mimica, Ninoslav ^f   Muck Seler, Dorotea ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b KBC Zagreb   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

^d brankarestek petrovic pbsvihr   (Croatia)

^e INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^f Psychiatric Hospital Vrap e   (Croatia)

Author keywords

Alzheimer's disease; Brain derived neurotrophic factor Val66Met; Male and female subjects; Onset of disease; Psychotic symptoms

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DNA;

AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; CROATIA; DEMENTIA; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; MUTATIONAL ANALYSIS; NERVE CELL PLASTICITY; PSYCHOSIS; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM;

AGE FACTORS; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CROATIA; DISEASE PROGRESSION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SEX FACTORS; TIME FACTORS;

EID: 79952900729     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.10.020     Document Type: Article

References (64)

1. Diagnostic and statistical manual of mental disorders 1994, APA, American Psychiatric Press, Washington, DC. IV ed.
2. Bian J.T., Zhang J.W., Zhang Z.X., Zhao H.L. Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese. Neurosci Lett 2005, 387:11-16.
3. Borroni B., Grassi M., Agosti C., Costanzi C., Archetti S., Franzoni S., et al. Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and APOE polymorphisms. Neurobiol Aging 2006, 27:1595-1603.
4. Borroni B., Grassi M., Archetti S., Costanzi C., Bianchi M., Caimi L., et al. BDNF genetic variations increase the risk of Alzheimer disease-related depression. J Alzheimers Dis 2009, 18:867-875.
5. Borroni B., Costanzi C., Padovani A. Genetic susceptibility to behavioural and psychological symptoms in Alzheimer disease. Curr Alzheimer Res 2010, 7:158-164.
6. Bueller J.A., Aftab M., Sen S., Gomez-Hassan D., Burmeister M., Zubieta J.K. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 2006, 59:812-815.
7. Candore G., Balistreri C.R., Grimaldi M.P., Vasto S., Listi F., Chiappelli M., et al. Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease. Ann NY Acad Sci 2006, 1089:472-486.
8. Chen Z.Y., Patel P.D., Sant G., Meng C.X., Teng K.K., Hempstead B.L., et al. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004, 24:4401-4411.
9. Cummings J.L. Alzheimer's disease. N Engl J Med 2004, 351:56-67.
10. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
11. Desai P., Nebes R., DeKosky S.T., Kamboh M.I. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci Lett 2005, 379:229-234.
12. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
13. Findeis M.A. The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol Ther 2007, 116:266-286.
14. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
15. Forero D.A., Benitez B., Arboleda G., Yunis J.J., Pardo R., Arboleda H. Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT and UCHL1) in Alzheimer's disease in Colombia. Neurosci Res 2006, 55:334-341.
16. Fratiglioni L., Launer L.J., Andersen K., Breteler M.M., Copeland J.R., Dartigues J.F., et al. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000, 54:S10-S15.
17. Frey H.J., Mattila K.M., Korolainen M.A., Pirttila T. Problems associated with biological markers of Alzheimer's disease. Neurochem Res 2005, 30:1501-1510.
18. Fukumoto N., Fujii T., Combarros O., Kamboh M.I., Tsai S.J., Matsushita S., et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: new data and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2010, 153B:235-242.
19. Fumagalli F., Racagni G., Riva M.A. The expanding role of BDNF: a therapeutic target for Alzheimer's disease?. Pharmacogenomics J 2006, 6:8-15.
20. Goldberg T.E., Weinberger D.R. Genes and the parsing of cognitive processes. Trends Cogn Sci 2004, 8:325-335.
21. Gratacos M., Gonzalez J.R., Mercader J.M., de Cid R., Urretavizcaya M., Estivill X. Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 2007, 61:911-922.
22. Grunblatt E., Zehetmayer S., Bartl J., Loffler C., Wichart I., Rainer M.K., et al. Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study. J Psychiatr Res 2009, 43:298-308.
23. Hariri A.R., Goldberg T.E., Mattay V.S., Kolachana B.S., Callicott J.H., Egan M.F., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 2003, 23:6690-6694.
24. Harris S.E., Wright A.F., Hayward C., Starr J.M., Whalley L.J., Deary I.J. The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79year olds. Neurosci Lett 2005, 385:1-6.
25. He X.M., Zhang Z.X., Zhang J.W., Zhou Y.T., Tang M.N., Wu C.B., et al. Lack of association between BDNF gene Val66Met polymorphism and Alzheimer disease in Chinese Han population. Neuropsychobiology 2007, 55:151-155.
26. Hock C., Heese K., Hulette C., Rosenberg C., Otten U. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 2000, 57:846-851.
27. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001, 24:677-736.
28. Jeste D.V., Finkel S.I. Psychosis of Alzheimer's disease and related dementias: diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry 2000, 8:29-34.
29. Jonsson E.G., Edman-Ahlbom B., Sillen A., Gunnar A., Kulle B., Frigessi A., et al. Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30:924-933.
30. Kawas C.H. Clinical practice. Early Alzheimer's disease. N Engl J Med 2003, 349:1056-1063.
31. Laske C., Stransky E., Leyhe T., Eschweiler G.W., Maetzler W., Wittorf A., et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 2007, 41:387-394.
32. Lee J., Fukumoto H., Orne J., Klucken J., Raju S., Vanderburg C.R., et al. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol 2005, 194:91-96.
33. Li Y., Rowland C., Tacey K., Catanese J., Sninsky J., Hardy J., et al. The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Mol Psychiatry 2005, 10:809-810.
34. Matsushita S., Arai H., Matsui T., Yuzuriha T., Urakami K., Masaki T., et al. Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. J Neural Transm 2005, 112:703-711.
35. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
36. Mega M.S., Cummings J.L., Fiorello T., Gornbein J. The spectrum of behavioral changes in Alzheimer's disease. Neurology 1996, 46:130-135.
37. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988, 16:1215.
38. Moran E.K., Becker J.A., Satlin A., Lyoo I.K., Fischman A.J., Johnson K.A. Psychosis of Alzheimer's disease: gender differences in regional perfusion. Nerobiol Aging 2008, 29:1218-1225.
39. Nacmias B., Piccini C., Bagnoli S., Tedde A., Cellini L., Bracco L., et al. Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer's disease. Neurosci Lett 2004, 367:379-383.
40. Numata S., Ueno S., Iga J., Yamauchi K., Hongwei S., Ohta K., et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett 2006, 401:1-5.
41. Paulsen J.S., Salmon D.P., Thal L.J., Romero R., Weisstein-Jenkins C., Galasko D., et al. Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology 2000, 54:1965-1971.
42. Pezawas L., Verchinski B.A., Mattay V.S., Callicott J.H., Kolachana B.S., Straub R.E., et al. The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 2004, 24:10099-10102.
43. Pillai A., Kale A., Joshi S., Naphade N., Raju M.S., Nasrallah H., et al. Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology. Int J Neuropsychopharmacol 2010, 13:535-539.
44. Pivac N., Kim B., Nedic G., Joo Y.H., Kozaric-Kovacic D., Hong J.P., et al. Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy participants. Croat Med J 2009, 50:43-48.
45. Rosa A., Cuesta M.J., Fatjo-Vilas M., Peralta V., Zarzuela A., Fananas L. The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study. Am J Med Genet B Neuropsychiatr Genet 2006, 141B:135-138.
46. Russo-Neustadt A. Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders. Semin Clin Neuropsychiatry 2003, 8:109-118.
47. Schneider L.S., Dagerman K.S. Psychosis of Alzheimer's disease: clinical characteristics and history. J Psychiatr Res 2004, 38:105-111.
48. Serretti A., Olgiati P., De Ronchi D. Genetics of Alzheimer's disease. A rapidly evolving field. J Alzheimers Dis 2007, 12:73-92.
49. Simons C.J.P., Wichers M., Derom C., Thiery E., Myin-Germeys I., Krabbendam L., et al. Subtle gene-environment interactions driving paranoia in daily life. Genes Brain Behav 2009, 8:5-12.
50. Spalletta G., Bernardini S., Bellincampi L., Federici G., Trequattrini A., Caltagirone C. Delusion symptoms are associated with ApoE-4 allelic variant at the early stage of Alzheimer's disease with late onset. Eur J Neurol 2006, 13:176-182.
51. Tapia-Arancibia L., Aliaga E., Silhol M., Arancibia S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 2008, 59:201-220.
52. Tsai S.J., Hong C.J., Liu H.C., Liu T.Y., Hsu L.E., Lin C.H. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 2004, 49:10-12.
53. Tsai S.J., Hong C.J., Liu H.C., Liu T.Y., Liou Y.J. The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a Chinese population. Dement Geriatr Cogn Disord 2006, 21:139-143.
54. Ventriglia M., Bocchio Chiavetto L., Benussi L., Binetti G., Zanetti O., Riva M.A., et al. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 2002, 7:136-137.
55. Vepsalainen S., Castren E., Helisalmi S., Iivonen S., Mannermaa A., Lehtovirta M., et al. Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease. J Neurol 2005, 252:423-428.
56. Verhagen M., van der Meij A., van Deurzen P.A.M., Janzing J.G.E., Arias-Vásquez A., Buitelaar J.K., et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2010, 15:260-271.
57. Wenk G.L. Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry 2003, 64(Suppl 9):7-10.
58. World Health Organization: international statistical classification of diseases and related health problems, Tenth revision 1992 (ICD-10) 1992, World Health Organization, Geneva.
59. Xu J., Turner A., Little J., Bleecker E.R., Meyers D.A. Positive results in association studies are associated with departure from Hardy Weinberg equilibrium: hint for genotyping error?. Hum Genet 2002, 111:573-574.
60. Yamada K., Mizuno M., Nabeshima T. Role for brain-derived neurotrophic factor in learning and memory. Life Sci 2002, 70:735-744.
61. Yasutake C., Kuroda K., Yanagawa T., Okamura T., Yoneda H. TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. Eur Arch Psychiatry Clin Neurosci 2006, 256:402-406.
62. Zdanys K.F., Kleiman T.G., MacAvoy M.G., Black B.T., Rightmer T.E., Grey M., et al. Neuropsychiatric evaluation. Apolipoprotein E e4 allele increases risk for psychotic symptoms in Alzheimer's Disease. Neuropsychopharmacology 2007, 32:171-179.
63. Zhang H., Ozbay F., Lappalainen J., Kranzler H.R., van Dyck C.H., Charney D.S., et al. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am J Med Genet B Neuropsychiatr Genet 2006, 141B:387-393.
64. Zhou D.H., Yan Q.Z., Yan X.M., Li C.B., Fang H., Zheng Y.L., et al. The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. Prog Neuro Psychopharmacol Biol Psychiatry 2010, 34:930-933.