Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 1, 2011, Pages 87-93

  Liu, Rui ^a   Tang, Audrey May Yi ^a   Tan, Yen Ling ^a   Limenta, Lie Michael George ^a   Lee, Edmund Jon Deoon ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Asian; Cephalexin pharmacokinetics; PEPT2 (SLC15A2) pharmacogenetics

Indexed keywords

AMMONIUM CHLORIDE; BICARBONATE; CEFALEXIN; PEPTIDE TRANSPORTER 2;

ADULT; AREA UNDER THE CURVE; ARTICLE; BEDTIME DOSAGE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; GENETIC VARIABILITY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY CLEARANCE; MALE; NORMAL HUMAN; OPEN STUDY; PH MEASUREMENT; PLASMA CONCENTRATION-TIME CURVE; RANDOMIZED CONTROLLED TRIAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; URINE PH;

EID: 79952789499     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-039     Document Type: Article

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