Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects

European Journal of Clinical Pharmacology

Volumn 65, Issue 1, 2009, Pages 65-70

  Liu, Rui ^a   Tang, Audrey May Yi ^a   Tan, Yen Ling ^a   Limenta, Lie Michael George ^a   Lee, Edmund Jon Deoon ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cephalexin; Haplotype; PEPT2 (SLC15A2); Polymorphism; Renal clearance

Indexed keywords

CEFALEXIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASIAN INDIAN; BODY WEIGHT; CHINESE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG URINE LEVEL; ETHNIC DIFFERENCE; ETHNIC GROUP; FEMALE; GENE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; MALAY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PEPT2 GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; CEPHALEXIN; CHINA; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; INDIA; MALAYSIA; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SINGAPORE; SYMPORTERS; YOUNG ADULT;

EID: 57849096125     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0488-4     Document Type: Article

References (31)

1. K Takahashi N Nakamura T Terada T Okano T Futami H Saito KI Inui 1998 Interaction of beta-lactam antibiotics with H + /peptide cotransporters in rat renal brush-border membranes J Pharmacol Exp Ther 286 2 1037 1042
2. DE Smith A Pavlova UV Berger MA Hediger T Yang YG Huang JB Schnermann 1998 Tubular localization and tissue distribution of peptide transporters in rat kidney Pharm Res 15 8 1244 1249
3. H Shen DE Smith T Yang YG Huang JB Schnermann FC Brosius 1999 Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney Am J Physiol 276 5 Pt 2 F658 665
4. ME Ganapathy W Huang H Wang V Ganapathy FH Leibach 1998 Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2 Biochem Biophys Res Commun 246 2 470 475
5. J Pinsonneault CU Nielsen W Sadée 2004 Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions J Pharmacol Exp Ther 311 3 1088 1096
6. PM Bahadduri VM D'Souza JK Pinsonneault W Sadée S Bao DL Knoell PW Swaan 2005 Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium Am J Respir Cell Mol Biol 32 4 319 325
7. A Maïza PT Daley-Yates 1993 Variability in the renal clearance of cephalexin in experimental renal failure J Pharmacokinet Biopharm 21 1 19 30
8. CA Gustaferro JM Steckelberg 1991 Cephalosporin antimicrobial agents and related compounds Mayo Clin Proc 66 10 1064 1073
9. T Terada H Saito M Mukai K Inui 1997 Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells Am J Physiol 273 5 Pt 2 F706 711
10. L Granero MJ Gimeno F Torres-Molina J Chesa-Jiménez JE Peris 1994 Studies on the renal excretion mechanisms of cefadroxil Drug Metab Dispos 22 3 447 450
11. C Padoin M Tod G Perret O Petitjean 1998 Analysis of the pharmacokinetic interaction between cephalexin and quinapril by a nonlinear mixed-effect model Antimicrob Agents Chemother 42 6 1463 1469
12. P Luckner M Brandsch 2005 Interaction of 31 beta-lactam antibiotics with the H + /peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1 Eur J Pharm Biopharm 59 1 17 24
13. R Hori K Okumura A Kamiya H Nihira H Nakano 1983 Ampicillin and cephalexin in renal insufficiency Clin Pharmacol Ther 34 6 792 798
14. A Kamiya K Okumura R Hori 1983 Quantitative investigation on renal handling of drugs in rabbits, dogs, and humans J Pharm Sci 72 4 440 443
15. OQ Yin B Tomlinson MS Chow 2006 Variability in renal clearance of substrates for renal transporters in Chinese subjects J Clin Pharmacol 46 2 157 163
16. F Pelloquin JP Lamelin GM Lenoir 1986 Human B lymphocytes immortalization by Epstein-Barr virus in the presence of cyclosporin A In Vitro Cell Dev Biol 22 12 689 694
17. GW Ying CG Lee EJ Lee 2004 A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production Mol Genet Metab 81 1 65 69
18. PM Kovach RJ Lantz G Brier 1991 High-performance liquid chromatographic determination of loracarbef, a potential metabolite, cefaclor and cephalexin in human plasma, serum and urine J Chromatogr 567 1 129 139
19. RH Barbhaiya 1996 A pharmacokinetic comparison of cefadroxil and cephalexin after administration of 250, 500 and 1000 mg solution doses Biopharm Drug Dispos 17 4 319 330
20. JM Brogard M Pinget M Dorner J Lavillaureix 1975 Determination of cefalexin pharmacokinetics and dosage adjustments in relation to renal function J Clin Pharmacol 15 10 666 673
21. P Actor DH Pitkin G Lucyszyn JA Weisbach JL Bran 1976 Cefatrizine (SK&F 60771), a new oral cephalosporin: serum levels and urinary recovery in humans after oral or intramuscular administration-comparative study with cephalexin and cefazolin Antimicrob Agents Chemother 9 5 800 803
22. M Pfeffer A Jackson J Ximenes JP de Menezes 1977 Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine Antimicrob Agents Chemother 11 2 331 8
23. OM Korzeniowski WM Scheld MA Sande 1977 Comparative pharmacology of cefaclor and cephalexin Antimicrob Agents Chemother 12 2 157 162
24. AI Hartstein KE Patrick SR Jones MJ Miller RE Bryant 1977 Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin Antimicrob Agents Chemother 12 1 93 97
25. DA Spyker BL Thomas MA Sande WK Bolton 1978 Pharmacokinetics of cefaclor and cephalexin: dosage nomograms for impaired renal function Antimicrob Agents Chemother 14 2 172 177
26. H Lode R Stahlmann P Koeppe 1979 Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000 Antimicrob Agents Chemother 16 1 1 6
27. JB Lecaillon JL Hirtz JP Schoeller G Humbert W Vischer 1980 Pharmacokinetic comparison of cefroxadin (CGP 9000) and cephalexin by simultaneous administration to humans Antimicrob Agents Chemother 18 5 656 660
28. RS Griffith HR Black 1970 Cephalexin Med Clin North Am 54 5 1229 1244
29. D Herrera-Ruiz GT Knipp 2003 Current perspectives on established and putative mammalian oligopeptide transporters J Pharm Sci 92 4 691 714
30. I Rubio-Aliaga H Daniel 2002 Mammalian peptide transporters as targets for drug delivery Trends Pharmacol Sci 23 9 434 440
31. MJ Dresser MK Leabman KM Giacomini 2001 Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters J Pharm Sci 90 4 397 421